604 related articles for article (PubMed ID: 12890772)
1. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
Cataldo AM; Petanceska S; Peterhoff CM; Terio NB; Epstein CJ; Villar A; Carlson EJ; Staufenbiel M; Nixon RA
J Neurosci; 2003 Jul; 23(17):6788-92. PubMed ID: 12890772
[TBL] [Abstract][Full Text] [Related]
2. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
Cataldo AM; Peterhoff CM; Troncoso JC; Gomez-Isla T; Hyman BT; Nixon RA
Am J Pathol; 2000 Jul; 157(1):277-86. PubMed ID: 10880397
[TBL] [Abstract][Full Text] [Related]
3. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
Chen XQ; Salehi A; Pearn ML; Overk C; Nguyen PD; Kleschevnikov AM; Maccecchini M; Mobley WC
Alzheimers Dement; 2021 Feb; 17(2):271-292. PubMed ID: 32975365
[TBL] [Abstract][Full Text] [Related]
4. Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome.
Arriagada C; Astorga C; Atwater I; Rojas E; Mears D; Caviedes R; Caviedes P
Neurosci Lett; 2007 Aug; 423(2):172-7. PubMed ID: 17706358
[TBL] [Abstract][Full Text] [Related]
5. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.
Kim S; Sato Y; Mohan PS; Peterhoff C; Pensalfini A; Rigoglioso A; Jiang Y; Nixon RA
Mol Psychiatry; 2016 May; 21(5):707-16. PubMed ID: 26194181
[TBL] [Abstract][Full Text] [Related]
6. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
Kwart D; Gregg A; Scheckel C; Murphy EA; Paquet D; Duffield M; Fak J; Olsen O; Darnell RB; Tessier-Lavigne M
Neuron; 2019 Oct; 104(2):256-270.e5. PubMed ID: 31416668
[TBL] [Abstract][Full Text] [Related]
7. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
Xu W; Weissmiller AM; White JA; Fang F; Wang X; Wu Y; Pearn ML; Zhao X; Sawa M; Chen S; Gunawardena S; Ding J; Mobley WC; Wu C
J Clin Invest; 2016 May; 126(5):1815-33. PubMed ID: 27064279
[TBL] [Abstract][Full Text] [Related]
8. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
García-Cerro S; Rueda N; Vidal V; Lantigua S; Martínez-Cué C
Neurobiol Dis; 2017 Oct; 106():76-88. PubMed ID: 28647555
[TBL] [Abstract][Full Text] [Related]
9. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
Jiang Y; Rigoglioso A; Peterhoff CM; Pawlik M; Sato Y; Bleiwas C; Stavrides P; Smiley JF; Ginsberg SD; Mathews PM; Levy E; Nixon RA
Neurobiol Aging; 2016 Mar; 39():90-8. PubMed ID: 26923405
[TBL] [Abstract][Full Text] [Related]
10. Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.
Colacurcio DJ; Pensalfini A; Jiang Y; Nixon RA
Free Radic Biol Med; 2018 Jan; 114():40-51. PubMed ID: 28988799
[TBL] [Abstract][Full Text] [Related]
11. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.
Cataldo AM; Petanceska S; Terio NB; Peterhoff CM; Durham R; Mercken M; Mehta PD; Buxbaum J; Haroutunian V; Nixon RA
Neurobiol Aging; 2004; 25(10):1263-72. PubMed ID: 15465622
[TBL] [Abstract][Full Text] [Related]
12. Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
Jiang Y; Sato Y; Im E; Berg M; Bordi M; Darji S; Kumar A; Mohan PS; Bandyopadhyay U; Diaz A; Cuervo AM; Nixon RA
J Neurosci; 2019 Jul; 39(27):5255-5268. PubMed ID: 31043483
[TBL] [Abstract][Full Text] [Related]
13. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.
Cataldo AM; Mathews PM; Boiteau AB; Hassinger LC; Peterhoff CM; Jiang Y; Mullaney K; Neve RL; Gruenberg J; Nixon RA
Am J Pathol; 2008 Aug; 173(2):370-84. PubMed ID: 18535180
[TBL] [Abstract][Full Text] [Related]
14. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
Grbovic OM; Mathews PM; Jiang Y; Schmidt SD; Dinakar R; Summers-Terio NB; Ceresa BP; Nixon RA; Cataldo AM
J Biol Chem; 2003 Aug; 278(33):31261-8. PubMed ID: 12761223
[TBL] [Abstract][Full Text] [Related]
15. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC
Neuron; 2006 Jul; 51(1):29-42. PubMed ID: 16815330
[TBL] [Abstract][Full Text] [Related]
16. Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes.
Cossec JC; Lavaur J; Berman DE; Rivals I; Hoischen A; Stora S; Ripoll C; Mircher C; Grattau Y; Olivomarin JC; de Chaumont F; Lecourtois M; Antonarakis SE; Veltman JA; Delabar JM; Duyckaerts C; Di Paolo G; Potier MC
Hum Mol Genet; 2012 Jul; 21(14):3156-72. PubMed ID: 22511594
[TBL] [Abstract][Full Text] [Related]
17. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
Jiang Y; Mullaney KA; Peterhoff CM; Che S; Schmidt SD; Boyer-Boiteau A; Ginsberg SD; Cataldo AM; Mathews PM; Nixon RA
Proc Natl Acad Sci U S A; 2010 Jan; 107(4):1630-5. PubMed ID: 20080541
[TBL] [Abstract][Full Text] [Related]
18. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
Shen R; Zhao X; He L; Ding Y; Xu W; Lin S; Fang S; Yang W; Sung K; Spencer B; Rissman RA; Lei M; Ding J; Wu C
Transl Neurodegener; 2020 Jun; 9(1):26. PubMed ID: 32552912
[TBL] [Abstract][Full Text] [Related]
19. Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.
Mumford P; Tosh J; Anderle S; Gkanatsiou Wikberg E; Lau G; Noy S; Cleverley K; Saito T; Saido TC; Yu E; Brinkmalm G; Portelius E; Blennow K; Zetterberg H; Tybulewicz V; Fisher EMC; Wiseman FK
J Neurosci; 2022 Aug; 42(33):6453-6468. PubMed ID: 35835549
[TBL] [Abstract][Full Text] [Related]
20. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.
Granholm AC; Sanders L; Seo H; Lin L; Ford K; Isacson O
Hippocampus; 2003; 13(8):905-14. PubMed ID: 14750653
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
