BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 12901914)

  • 1. Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase.
    Hamilton CJ; Saravanamuthu A; Fairlamb AH; Eggleston IM
    Bioorg Med Chem; 2003 Aug; 11(17):3683-93. PubMed ID: 12901914
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
    Li Z; Fennie MW; Ganem B; Hancock MT; Kobaslija M; Rattendi D; Bacchi CJ; O'Sullivan MC
    Bioorg Med Chem Lett; 2001 Jan; 11(2):251-4. PubMed ID: 11206471
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Optimising inhibitors of trypanothione reductase using solid-phase chemistry.
    Chitkul B; Bradley M
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2367-9. PubMed ID: 11055357
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products.
    Hamilton CJ; Saravanamuthu A; Poupat C; Fairlamb AH; Eggleston IM
    Bioorg Med Chem; 2006 Apr; 14(7):2266-78. PubMed ID: 16303308
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
    O'Sullivan MC; Durham TB; Valdes HE; Dauer KL; Karney NJ; Forrestel AC; Bacchi CJ; Baker JF
    Bioorg Med Chem; 2015 Mar; 23(5):996-1010. PubMed ID: 25661449
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibiting effects of spermidine derivatives on Trypanosoma cruzi trypanothione reductase.
    O'Sullivan MC; Dalrymple DM; Zhou Q
    J Enzyme Inhib; 1996 Oct; 11(2):97-114. PubMed ID: 9204399
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.
    Salmon L; Landry V; Melnyk O; Maes L; Sergheraert C; Davioud-Charvet E
    Chem Pharm Bull (Tokyo); 1998 Apr; 46(4):707-10. PubMed ID: 9579046
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase.
    Smith HK; Bradley M
    J Comb Chem; 1999; 1(4):326-32. PubMed ID: 10748738
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
    Salmon-Chemin L; Buisine E; Yardley V; Kohler S; Debreu MA; Landry V; Sergheraert C; Croft SL; Krauth-Siegel RL; Davioud-Charvet E
    J Med Chem; 2001 Feb; 44(4):548-65. PubMed ID: 11170645
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.
    Girault S; Davioud-Charvet E; Salmon L; Berecibar A; Debreu MA; Sergheraert C
    Bioorg Med Chem Lett; 1998 May; 8(10):1175-80. PubMed ID: 9871730
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities.
    O'Sullivan MC; Zhou Q; Li Z; Durham TB; Rattendi D; Lane S; Bacchi CJ
    Bioorg Med Chem; 1997 Dec; 5(12):2145-55. PubMed ID: 9459012
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.
    Patterson S; Jones DC; Shanks EJ; Frearson JA; Gilbert IH; Wyatt PG; Fairlamb AH
    ChemMedChem; 2009 Aug; 4(8):1341-53. PubMed ID: 19557802
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.
    Richardson JL; Nett IR; Jones DC; Abdille MH; Gilbert IH; Fairlamb AH
    ChemMedChem; 2009 Aug; 4(8):1333-40. PubMed ID: 19557801
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.
    Ponasik JA; Strickland C; Faerman C; Savvides S; Karplus PA; Ganem B
    Biochem J; 1995 Oct; 311 ( Pt 2)(Pt 2):371-5. PubMed ID: 7487870
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibitors of trypanothione reductase as potential antitrypanosomal drugs.
    Chan C; Yin H; Garforth J; McKie JH; Jaouhari RA; Douglas KT; Fairlamb AH; Croft SL
    Biochem Soc Trans; 1995 Nov; 23(4):511S. PubMed ID: 8654696
    [No Abstract]   [Full Text] [Related]  

  • 16. Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.
    Arias DG; Herrera FE; Garay AS; Rodrigues D; Forastieri PS; Luna LE; Bürgi MD; Prieto C; Iglesias AA; Cravero RM; Guerrero SA
    Eur J Med Chem; 2017 Jan; 125():1088-1097. PubMed ID: 27810595
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
    Hartmann AP; de Carvalho MR; Bernardes LSC; Moraes MH; de Melo EB; Lopes CD; Steindel M; da Silva JS; Carvalho I
    Eur J Med Chem; 2017 Nov; 140():187-199. PubMed ID: 28926763
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Chan C; Yin H; Garforth J; McKie JH; Jaouhari R; Speers P; Douglas KT; Rock PJ; Yardley V; Croft SL; Fairlamb AH
    J Med Chem; 1998 Jan; 41(2):148-56. PubMed ID: 9457238
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
    Jagu E; Pomel S; Diez-Martinez A; Ramiandrasoa F; Krauth-Siegel RL; Pethe S; Blonski C; Labruère R; Loiseau PM
    Bioorg Med Chem; 2017 Jan; 25(1):84-90. PubMed ID: 27793448
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of potential trypanothione reductase inhibitors among commercially available β-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.
    Rodríguez-Becerra J; Cáceres-Jensen L; Hernández-Ramos J; Barrientos L
    Mol Divers; 2017 Aug; 21(3):697-711. PubMed ID: 28656524
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.