BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 12904076)

  • 1. A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.
    Robichaud J; Oballa R; Prasit P; Falgueyret JP; Percival MD; Wesolowski G; Rodan SB; Kimmel D; Johnson C; Bryant C; Venkatraman S; Setti E; Mendonca R; Palmer JT
    J Med Chem; 2003 Aug; 46(17):3709-27. PubMed ID: 12904076
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.
    Falgueyret JP; Oballa RM; Okamoto O; Wesolowski G; Aubin Y; Rydzewski RM; Prasit P; Riendeau D; Rodan SB; Percival MD
    J Med Chem; 2001 Jan; 44(1):94-104. PubMed ID: 11141092
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
    Stroup GB; Lark MW; Veber DF; Bhattacharyya A; Blake S; Dare LC; Erhard KF; Hoffman SJ; James IE; Marquis RW; Ru Y; Vasko-Moser JA; Smith BR; Tomaszek T; Gowen M
    J Bone Miner Res; 2001 Oct; 16(10):1739-46. PubMed ID: 11585335
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
    Lark MW; Stroup GB; James IE; Dodds RA; Hwang SM; Blake SM; Lechowska BA; Hoffman SJ; Smith BR; Kapadia R; Liang X; Erhard K; Ru Y; Dong X; Marquis RW; Veber D; Gowen M
    Bone; 2002 May; 30(5):746-53. PubMed ID: 11996914
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
    Kumar S; Dare L; Vasko-Moser JA; James IE; Blake SM; Rickard DJ; Hwang SM; Tomaszek T; Yamashita DS; Marquis RW; Oh H; Jeong JU; Veber DF; Gowen M; Lark MW; Stroup G
    Bone; 2007 Jan; 40(1):122-31. PubMed ID: 16962401
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
    Setti EL; Venkatraman S; Palmer JT; Xie X; Cheung H; Yu W; Wesolowski G; Robichaud J
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4296-9. PubMed ID: 16750630
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
    Palmer JT; Bryant C; Wang DX; Davis DE; Setti EL; Rydzewski RM; Venkatraman S; Tian ZQ; Burrill LC; Mendonca RV; Springman E; McCarter J; Chung T; Cheung H; Janc JW; McGrath M; Somoza JR; Enriquez P; Yu ZW; Strickley RM; Liu L; Venuti MC; Percival MD; Falgueyret JP; Prasit P; Oballa R; Riendeau D; Young RN; Wesolowski G; Rodan SB; Johnson C; Kimmel DB; Rodan G
    J Med Chem; 2005 Dec; 48(24):7520-34. PubMed ID: 16302794
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
    Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Irie O; Teno N; Lattmann R; Tintelnot-Blomley M; Missbach M
    J Med Chem; 2007 Feb; 50(4):591-4. PubMed ID: 17256925
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
    James IE; Marquis RW; Blake SM; Hwang SM; Gress CJ; Ru Y; Zembryki D; Yamashita DS; McQueney MS; Tomaszek TA; Oh HJ; Gowen M; Veber DF; Lark MW
    J Biol Chem; 2001 Apr; 276(15):11507-11. PubMed ID: 11148212
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.
    Svelander L; Erlandsson-Harris H; Astner L; Grabowska U; Klareskog L; Lindstrom E; Hewitt E
    Eur J Pharmacol; 2009 Jun; 613(1-3):155-62. PubMed ID: 19358841
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
    Patterson AW; Wood WJ; Hornsby M; Lesley S; Spraggon G; Ellman JA
    J Med Chem; 2006 Oct; 49(21):6298-307. PubMed ID: 17034136
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent and selective cathepsin K inhibitors.
    Shinozuka T; Shimada K; Matsui S; Yamane T; Ama M; Fukuda T; Taki M; Takeda Y; Otsuka E; Yamato M; Mochizuki S; Ohhata K; Naito S
    Bioorg Med Chem; 2006 Oct; 14(20):6789-806. PubMed ID: 16842999
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats.
    Kim MK; Kim HD; Park JH; Lim JI; Yang JS; Kwak WY; Sung SY; Kim HJ; Kim SH; Lee CH; Shim JY; Bae MH; Shin YA; Huh Y; Han TD; Chong W; Choi H; Ahn BN; Yang SO; Son MH
    J Pharmacol Exp Ther; 2006 Aug; 318(2):555-62. PubMed ID: 16699068
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.
    Frizler M; Schmitz J; Schulz-Fincke AC; Gütschow M
    J Med Chem; 2012 Jun; 55(12):5982-6. PubMed ID: 22686657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization.
    Lemke C; Cianni L; Feldmann C; Gilberg E; Yin J; Dos Reis Rocho F; de Vita D; Bartz U; Bajorath J; Montanari CA; Gütschow M
    Bioorg Med Chem Lett; 2020 Sep; 30(18):127420. PubMed ID: 32763808
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The consequences of lysosomotropism on the design of selective cathepsin K inhibitors.
    Black WC; Percival MD
    Chembiochem; 2006 Oct; 7(10):1525-35. PubMed ID: 16921579
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
    Yasuma T; Oi S; Choh N; Nomura T; Furuyama N; Nishimura A; Fujisawa Y; Sohda T
    J Med Chem; 1998 Oct; 41(22):4301-8. PubMed ID: 9784105
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats.
    Millest AJ; Breen SA; Loveday BE; Clarkson PN; Simpson CA; Waterton JC; Johnstone D
    Bone; 1997 May; 20(5):465-71. PubMed ID: 9145244
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
    Löser R; Schilling K; Dimmig E; Gütschow M
    J Med Chem; 2005 Dec; 48(24):7688-707. PubMed ID: 16302809
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts.
    Furuyama N; Fujisawa Y
    Steroids; 2000 Jul; 65(7):371-8. PubMed ID: 10899536
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.