BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

222 related articles for article (PubMed ID: 12909738)

  • 1. A clinically relevant model of human pancreatic adenocarcinoma identifies patterns of metastasis associated with alterations of the TGF-beta/Smad4 signaling pathway.
    Holloway S; Davis M; Jaber R; Fleming J
    Int J Gastrointest Cancer; 2003; 33(1):61-9. PubMed ID: 12909738
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differential expression of transforming growth factor beta receptors in human pancreatic adenocarcinoma.
    Venkatasubbarao K; Ahmed MM; Mohiuddin M; Swiderski C; Lee E; Gower WR; Salhab KF; McGrath P; Strodel W; Freeman JW
    Anticancer Res; 2000; 20(1A):43-51. PubMed ID: 10769633
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
    Peng B; Fleming JB; Breslin T; Grau AM; Fojioka S; Abbruzzese JL; Evans DB; Ayers D; Wathen K; Wu T; Robertson KD; Chiao PJ
    Clin Cancer Res; 2002 Nov; 8(11):3628-38. PubMed ID: 12429655
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.
    Jazag A; Ijichi H; Kanai F; Imamura T; Guleng B; Ohta M; Imamura J; Tanaka Y; Tateishi K; Ikenoue T; Kawakami T; Arakawa Y; Miyagishi M; Taira K; Kawabe T; Omata M
    Oncogene; 2005 Jan; 24(4):662-71. PubMed ID: 15592526
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.
    Grau AM; Zhang L; Wang W; Ruan S; Evans DB; Abbruzzese JL; Zhang W; Chiao PJ
    Cancer Res; 1997 Sep; 57(18):3929-34. PubMed ID: 9307274
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.
    Schwarte-Waldhoff I; Volpert OV; Bouck NP; Sipos B; Hahn SA; Klein-Scory S; Lüttges J; Klöppel G; Graeven U; Eilert-Micus C; Hintelmann A; Schmiegel W
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9624-9. PubMed ID: 10944227
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
    Levy L; Hill CS
    Mol Cell Biol; 2005 Sep; 25(18):8108-25. PubMed ID: 16135802
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells.
    Wan M; Huang J; Jhala NC; Tytler EM; Yang L; Vickers SM; Tang Y; Lu C; Wang N; Cao X
    Am J Pathol; 2005 May; 166(5):1379-92. PubMed ID: 15855639
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
    Duda DG; Sunamura M; Lefter LP; Furukawa T; Yokoyama T; Yatsuoka T; Abe T; Inoue H; Motoi F; Egawa S; Matsuno S; Horii A
    Oncogene; 2003 Oct; 22(44):6857-64. PubMed ID: 14534532
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
    Subramanian G; Schwarz RE; Higgins L; McEnroe G; Chakravarty S; Dugar S; Reiss M
    Cancer Res; 2004 Aug; 64(15):5200-11. PubMed ID: 15289325
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.
    Villanueva A; García C; Paules AB; Vicente M; Megías M; Reyes G; de Villalonga P; Agell N; Lluís F; Bachs O; Capellá G
    Oncogene; 1998 Oct; 17(15):1969-78. PubMed ID: 9788440
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1.
    Fralix KD; Ahmed MM; Mattingly C; Swiderski C; McGrath PC; Venkatasubbarao K; Kamada N; Mohiuddin M; Strodel WE; Freeman JW
    Cancer; 2000 May; 88(9):2010-21. PubMed ID: 10813711
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
    Goggins M; Shekher M; Turnacioglu K; Yeo CJ; Hruban RH; Kern SE
    Cancer Res; 1998 Dec; 58(23):5329-32. PubMed ID: 9850059
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.
    Bartsch D; Barth P; Bastian D; Ramaswamy A; Gerdes B; Chaloupka B; Deiss Y; Simon B; Schudy A
    Cancer Lett; 1999 May; 139(1):43-9. PubMed ID: 10408907
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
    Loukopoulos P; Kanetaka K; Takamura M; Shibata T; Sakamoto M; Hirohashi S
    Pancreas; 2004 Oct; 29(3):193-203. PubMed ID: 15367885
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.
    Wilentz RE; Su GH; Dai JL; Sparks AB; Argani P; Sohn TA; Yeo CJ; Kern SE; Hruban RH
    Am J Pathol; 2000 Jan; 156(1):37-43. PubMed ID: 10623651
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.
    Schniewind B; Groth S; Sebens Müerköster S; Sipos B; Schäfer H; Kalthoff H; Fändrich F; Ungefroren H
    Oncogene; 2007 Jul; 26(33):4850-62. PubMed ID: 17297450
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
    Maurice D; Pierreux CE; Howell M; Wilentz RE; Owen MJ; Hill CS
    J Biol Chem; 2001 Nov; 276(46):43175-81. PubMed ID: 11553622
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.
    Montgomery E; Goggins M; Zhou S; Argani P; Wilentz R; Kaushal M; Booker S; Romans K; Bhargava P; Hruban R; Kern S
    Am J Pathol; 2001 Feb; 158(2):537-42. PubMed ID: 11159190
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
    Sunamura M; Lefter LP; Duda DG; Morita R; Inoue H; Yokoyama T; Yatsuoka T; Abe T; Egawa S; Furukawa T; Fukushige S; Oshimura M; Horii A; Matsuno S
    Pancreas; 2004 Apr; 28(3):311-6. PubMed ID: 15084978
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.