136 related articles for article (PubMed ID: 12916990)
1. Concise and enantioselective synthesis of Fmoc-Pmp(But)2-OH and design of potent Pmp-containing Grb2-SH2 domain antagonists.
Li P; Zhang M; Peach ML; Liu H; Yang D; Roller PP
Org Lett; 2003 Aug; 5(17):3095-8. PubMed ID: 12916990
[TBL] [Abstract][Full Text] [Related]
2. Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.
Yao ZJ; King CR; Cao T; Kelley J; Milne GW; Voigt JH; Burke TR
J Med Chem; 1999 Jan; 42(1):25-35. PubMed ID: 9888830
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Liu WQ; Vidal M; Olszowy C; Million E; Lenoir C; Dhôtel H; Garbay C
J Med Chem; 2004 Feb; 47(5):1223-33. PubMed ID: 14971902
[TBL] [Abstract][Full Text] [Related]
4. Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.
Lee K; Zhang M; Liu H; Yang D; Burke TR
J Med Chem; 2003 Jun; 46(13):2621-30. PubMed ID: 12801226
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
Oishi S; Karki RG; Kang SU; Wang X; Worthy KM; Bindu LK; Nicklaus MC; Fisher RJ; Burke TR
J Med Chem; 2005 Feb; 48(3):764-72. PubMed ID: 15689160
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity.
Shi ZD; Liu H; Zhang M; Worthy KM; Bindu L; Yang D; Fisher RJ; Burke TR
Bioorg Med Chem; 2005 Jul; 13(13):4200-8. PubMed ID: 15893931
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of 4-(alpha-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 src-homology 2 (Grb2 SH2) domain-binding peptides.
Kang SU; Worthy KM; Bindu LK; Zhang M; Yang D; Fisher RJ; Burke TR
J Med Chem; 2005 Aug; 48(16):5369-72. PubMed ID: 16078854
[TBL] [Abstract][Full Text] [Related]
8. Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.
Shi ZD; Wei CQ; Lee K; Liu H; Zhang M; Araki T; Roberts LR; Worthy KM; Fisher RJ; Neel BG; Kelley JA; Yang D; Burke TR
J Med Chem; 2004 Apr; 47(8):2166-9. PubMed ID: 15056012
[TBL] [Abstract][Full Text] [Related]
9. Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.
Song YL; Peach ML; Roller PP; Qiu S; Wang S; Long YQ
J Med Chem; 2006 Mar; 49(5):1585-96. PubMed ID: 16509576
[TBL] [Abstract][Full Text] [Related]
10. Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Liu WQ; Vidal M; Gresh N; Roques BP; Garbay C
J Med Chem; 1999 Sep; 42(18):3737-41. PubMed ID: 10479306
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.
Gao Y; Luo J; Yao ZJ; Guo R; Zou H; Kelley J; Voigt JH; Yang D; Burke TR
J Med Chem; 2000 Mar; 43(5):911-20. PubMed ID: 10715157
[TBL] [Abstract][Full Text] [Related]
12. Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.
Wei CQ; Gao Y; Lee K; Guo R; Li B; Zhang M; Yang D; Burke TR
J Med Chem; 2003 Jan; 46(2):244-54. PubMed ID: 12519063
[TBL] [Abstract][Full Text] [Related]
13. Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
Li P; Zhang M; Long YQ; Peach ML; Liu H; Yang D; Nicklaus M; Roller PP
Bioorg Med Chem Lett; 2003 Jul; 13(13):2173-7. PubMed ID: 12798329
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
Long YQ; Xue T; Song YL; Liu ZL; Huang SX; Yu Q
J Med Chem; 2008 Oct; 51(20):6371-80. PubMed ID: 18821748
[TBL] [Abstract][Full Text] [Related]
15. Grb2 SH2 domain-binding peptide analogs as potential anticancer agents.
Lung FD; Tsai JY
Biopolymers; 2003; 71(2):132-40. PubMed ID: 12767115
[TBL] [Abstract][Full Text] [Related]
16. N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding.
Burke TR; Yao ZJ; Gao Y; Wu JX; Zhu X; Luo JH; Guo R; Yang D
Bioorg Med Chem; 2001 Jun; 9(6):1439-45. PubMed ID: 11408162
[TBL] [Abstract][Full Text] [Related]
17. Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.
Lung FD; Chang CW; Chong MC; Liou CC; Li P; Peach ML; Nicklaus MC; Lou BS; Roller PP
Biopolymers; 2005; 80(5):628-35. PubMed ID: 15660381
[TBL] [Abstract][Full Text] [Related]
18. Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2.
Walker CV; Caravatti G; Denholm AA; Egerton J; Faessler A; Furet P; García-Echeverría C; Gay B; Irving E; Jones K; Lambert A; Press NJ; Woods J
Bioorg Med Chem Lett; 2000 Oct; 10(20):2343-6. PubMed ID: 11055352
[TBL] [Abstract][Full Text] [Related]
19. Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.
Li P; Zhang M; Peach ML; Zhang X; Liu H; Nicklaus M; Yang D; Roller PP
Biochem Biophys Res Commun; 2003 Aug; 307(4):1038-44. PubMed ID: 12878216
[TBL] [Abstract][Full Text] [Related]
20. Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity.
Song YL; Roller PP; Long YQ
Bioorg Med Chem Lett; 2004 Jun; 14(12):3205-8. PubMed ID: 15149676
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
