These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 12916990)

  • 21. Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.
    Wei CQ; Li B; Guo R; Yang D; Burke TR
    Bioorg Med Chem Lett; 2002 Oct; 12(19):2781-4. PubMed ID: 12217375
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Utilization of 3'-carboxy-containing tyrosine derivatives as a new class of phosphotyrosyl mimetics in the preparation of novel non-phosphorylated cyclic peptide inhibitors of the Grb2-SH2 domain.
    Song YL; Tan J; Luo XM; Long YQ
    Org Biomol Chem; 2006 Feb; 4(4):659-66. PubMed ID: 16467940
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
    Jiang S; Li P; Peach ML; Bindu L; Worthy KW; Fisher RJ; Burke TR; Nicklaus M; Roller PP
    Biochem Biophys Res Commun; 2006 Oct; 349(2):497-503. PubMed ID: 16945340
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.
    Shi ZD; Karki RG; Oishi S; Worthy KM; Bindu LK; Dharmawardana PG; Nicklaus MC; Bottaro DP; Fisher RJ; Burke TR
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1385-8. PubMed ID: 15713392
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Binding affinity difference induced by the stereochemistry of the sulfoxide bridge of the cyclic peptide inhibitors of Grb2-SH2 domain: NMR studies for the structural origin.
    Shi YH; Song YL; Lin DH; Tan J; Roller PP; Li Q; Long YQ; Song GQ
    Biochem Biophys Res Commun; 2005 May; 330(4):1254-61. PubMed ID: 15823578
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.
    Burke TR; Smyth MS; Otaka A; Nomizu M; Roller PP; Wolf G; Case R; Shoelson SE
    Biochemistry; 1994 May; 33(21):6490-4. PubMed ID: 7515682
    [TBL] [Abstract][Full Text] [Related]  

  • 27. New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors.
    Dourlat J; Valentin B; Liu WQ; Garbay C
    Bioorg Med Chem Lett; 2007 Jul; 17(14):3943-6. PubMed ID: 17509878
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.
    García-Echeverría C; Furet P; Gay B; Fretz H; Rahuel J; Schoepfer J; Caravatti G
    J Med Chem; 1998 May; 41(11):1741-4. PubMed ID: 9599224
    [No Abstract]   [Full Text] [Related]  

  • 29. Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
    Long YQ; Lung FD; Roller PP
    Bioorg Med Chem; 2003 Sep; 11(18):3929-36. PubMed ID: 12927853
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
    Long YQ; Guo R; Luo JH; Yang D; Roller PP
    Biochem Biophys Res Commun; 2003 Oct; 310(2):334-40. PubMed ID: 14521914
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design and synthesis of a beta-amino phosphotyrosyl mimetic suitably protected for peptide synthesis.
    Lee K; Zhang M; Yang D; Burke TR
    Bioorg Med Chem Lett; 2002 Dec; 12(23):3399-401. PubMed ID: 12419370
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
    Furet P; García-Echeverría C; Gay B; Schoepfer J; Zeller M; Rahuel J
    J Med Chem; 1999 Jul; 42(13):2358-63. PubMed ID: 10395476
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Structure-based design of a non-peptidic antagonist of the SH2 domain of GRB2.
    Caravatti G; Rahuel J; Gay B; Furet P
    Bioorg Med Chem Lett; 1999 Jul; 9(14):1973-8. PubMed ID: 10450965
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Solid-phase synthesis of "mixed" peptidomimetics using Fmoc-protected aza-beta3-amino acids and alpha-amino acids.
    Busnel O; Bi L; Dali H; Cheguillaume A; Chevance S; Bondon A; Muller S; Baudy-Floc'h M
    J Org Chem; 2005 Dec; 70(26):10701-8. PubMed ID: 16355988
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains.
    Vidal M; Liu WQ; Lenoir C; Salzmann J; Gresh N; Garbay C
    Biochemistry; 2004 Jun; 43(23):7336-44. PubMed ID: 15182177
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1.
    Furet P; Caravatti G; Denholm AA; Faessler A; Fretz H; García-Echeverría C; Gay B; Irving E; Press NJ; Rahuel J; Schoepfer J; Walker CV
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2337-41. PubMed ID: 11055351
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.
    de Mol NJ; Dekker FJ; Broutin I; Fischer MJ; Liskamp RM
    J Med Chem; 2005 Feb; 48(3):753-63. PubMed ID: 15689159
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne.
    Schoepfer J; Gay B; End N; Muller E; Scheffel G; Caravatti G; Furet P
    Bioorg Med Chem Lett; 2001 May; 11(9):1201-3. PubMed ID: 11354377
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Potent inhibition of insulin receptor dephosphorylation by a hexamer peptide containing the phosphotyrosyl mimetic F2Pmp.
    Burke TR; Kole HK; Roller PP
    Biochem Biophys Res Commun; 1994 Oct; 204(1):129-34. PubMed ID: 7524496
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.
    Burke TR; Luo J; Yao ZJ; Gao Y; Zhao H; Milne GW; Guo R; Voigt JH; King CR; Yang D
    Bioorg Med Chem Lett; 1999 Feb; 9(3):347-52. PubMed ID: 10091682
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.