BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 12920164)

  • 21. Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes.
    Iwatsubo T; Suzuki H; Shimada N; Chiba K; Ishizaki T; Green CE; Tyson CA; Yokoi T; Kamataki T; Sugiyama Y
    J Pharmacol Exp Ther; 1997 Aug; 282(2):909-19. PubMed ID: 9262358
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.
    Obach RS; Cox LM; Tremaine LM
    Drug Metab Dispos; 2005 Feb; 33(2):262-70. PubMed ID: 15547048
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices.
    Renwick AB; Watts PS; Edwards RJ; Barton PT; Guyonnet I; Price RJ; Tredger JM; Pelkonen O; Boobis AR; Lake BG
    Drug Metab Dispos; 2000 Oct; 28(10):1202-9. PubMed ID: 10997941
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.
    McGinnity DF; Waters NJ; Tucker J; Riley RJ
    Drug Metab Dispos; 2008 Jun; 36(6):1126-34. PubMed ID: 18356267
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes.
    Abass K; Reponen P; Turpeinen M; Jalonen J; Pelkonen O
    Drug Metab Dispos; 2007 Sep; 35(9):1634-41. PubMed ID: 17576805
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 27. In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics.
    Zhou D; Andersson TB; Grimm SW
    Drug Metab Dispos; 2011 Apr; 39(4):703-10. PubMed ID: 21177984
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.
    Foxenberg RJ; McGarrigle BP; Knaak JB; Kostyniak PJ; Olson JR
    Drug Metab Dispos; 2007 Feb; 35(2):189-93. PubMed ID: 17079358
    [TBL] [Abstract][Full Text] [Related]  

  • 29. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.
    Agrawal AK; Hop CE; Pang J; Silva Elipe MV; Desai RC; Leung KH; Franklin RB
    J Pharm Biomed Anal; 2005 Feb; 37(2):351-8. PubMed ID: 15708677
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.
    Miksanová M; Sulc M; Rýdlová H; Schmeiser HH; Frei E; Stiborová M
    Chem Res Toxicol; 2004 May; 17(5):663-71. PubMed ID: 15144223
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
    Brown HS; Wilby AJ; Alder J; Houston JB
    Drug Metab Dispos; 2010 Dec; 38(12):2139-46. PubMed ID: 20847136
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
    Gómez-Lechón MJ; Castell JV; Donato MT
    Chem Biol Interact; 2007 May; 168(1):30-50. PubMed ID: 17134688
    [TBL] [Abstract][Full Text] [Related]  

  • 33. 2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol.
    Franklin MR; Hathaway LB
    Drug Metab Dispos; 2008 Dec; 36(12):2539-46. PubMed ID: 18799803
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Lenalidomide: in vitro evaluation of the metabolism and assessment of cytochrome P450 inhibition and induction.
    Kumar G; Lau H; Laskin O
    Cancer Chemother Pharmacol; 2009 May; 63(6):1171-5. PubMed ID: 19030860
    [TBL] [Abstract][Full Text] [Related]  

  • 35. 3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid.
    Deo AK; Bandiera SM
    Drug Metab Dispos; 2009 Sep; 37(9):1938-47. PubMed ID: 19487251
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro.
    Veinlichova A; Jancova P; Siller M; Anzenbacher P; Kuca K; Jun D; Fusek J; Anzenbacherova E
    Chem Biol Interact; 2009 Aug; 180(3):449-53. PubMed ID: 19539805
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes.
    Ghosal A; Hapangama N; Yuan Y; Lu X; Horne D; Patrick JE; Zbaida S
    Biopharm Drug Dispos; 2003 Dec; 24(9):375-84. PubMed ID: 14689466
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
    Remmel RP; Crews BC; Kozak KR; Kalgutkar AS; Marnett LJ
    Drug Metab Dispos; 2004 Jan; 32(1):113-22. PubMed ID: 14709628
    [TBL] [Abstract][Full Text] [Related]  

  • 39. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes.
    Nassar AE; King I; Paris BL; Haupt L; Ndikum-Moffor F; Campbell R; Usuki E; Skibbe J; Brobst D; Ogilvie BW; Parkinson A
    Drug Metab Dispos; 2009 Sep; 37(9):1922-30. PubMed ID: 19520774
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.