These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 12926251)

  • 1. Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1.
    O'Brien SE; Browne HL; Bradshaw TD; Westwell AD; Stevens MF; Laughton CA
    Org Biomol Chem; 2003 Feb; 1(3):493-7. PubMed ID: 12926251
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2-(4-aminophenyl) benzothiazole: a potent and selective pharmacophore with novel mechanistic action towards various tumour cell lines.
    Dubey R; Shrivastava PK; Basniwal PK; Bhattacharya S; Moorthy NS
    Mini Rev Med Chem; 2006 Jun; 6(6):633-7. PubMed ID: 16787373
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
    Brantley E; Trapani V; Alley MC; Hose CD; Bradshaw TD; Stevens MF; Sausville EA; Stinson SF
    Drug Metab Dispos; 2004 Dec; 32(12):1392-401. PubMed ID: 15355884
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1.
    Wang K; Guengerich FP
    Chem Res Toxicol; 2012 Aug; 25(8):1740-51. PubMed ID: 22734839
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.
    Hutchinson I; Chua MS; Browne HL; Trapani V; Bradshaw TD; Westwell AD; Stevens MF
    J Med Chem; 2001 Apr; 44(9):1446-55. PubMed ID: 11311068
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.
    Kashiyama E; Hutchinson I; Chua MS; Stinson SF; Phillips LR; Kaur G; Sausville EA; Bradshaw TD; Westwell AD; Stevens MF
    J Med Chem; 1999 Oct; 42(20):4172-84. PubMed ID: 10514287
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
    Chua MS; Kashiyama E; Bradshaw TD; Stinson SF; Brantley E; Sausville EA; Stevens MF
    Cancer Res; 2000 Sep; 60(18):5196-203. PubMed ID: 11016648
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines.
    Chua MS; Shi DF; Wrigley S; Bradshaw TD; Hutchinson I; Shaw PN; Barrett DA; Stanley LA; Stevens MF
    J Med Chem; 1999 Feb; 42(3):381-92. PubMed ID: 9986708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
    Bradshaw TD; Bibby MC; Double JA; Fichtner I; Cooper PA; Alley MC; Donohue S; Stinson SF; Tomaszewjski JE; Sausville EA; Stevens MF
    Mol Cancer Ther; 2002 Feb; 1(4):239-46. PubMed ID: 12467219
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
    Leong CO; Gaskell M; Martin EA; Heydon RT; Farmer PB; Bibby MC; Cooper PA; Double JA; Bradshaw TD; Stevens MF
    Br J Cancer; 2003 Feb; 88(3):470-7. PubMed ID: 12569393
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
    Bradshaw TD; Wrigley S; Shi DF; Schultz RJ; Paull KD; Stevens MF
    Br J Cancer; 1998 Mar; 77(5):745-52. PubMed ID: 9514053
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues.
    Hutchinson I; Bradshaw TD; Matthews CS; Stevens MF; Westwell AD
    Bioorg Med Chem Lett; 2003 Feb; 13(3):471-4. PubMed ID: 12565953
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.
    Stone EL; Citossi F; Singh R; Kaur B; Gaskell M; Farmer PB; Monks A; Hose C; Stevens MF; Leong CO; Stocks M; Kellam B; Marlow M; Bradshaw TD
    Bioorg Med Chem; 2015 Nov; 23(21):6891-9. PubMed ID: 26474663
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate.
    Bradshaw TD; Westwell AD
    Curr Med Chem; 2004 Apr; 11(8):1009-21. PubMed ID: 15078163
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanisms of acquired resistance to 2-(4-aminophenyl)benzothiazole (CJM 126, NSC 34445).
    Bradshaw TD; Chua MS; Orr S; Matthews CS; Stevens MF
    Br J Cancer; 2000 Jul; 83(2):270-7. PubMed ID: 10901382
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds.
    Tumbi KM; Nandekar PP; Shaikh N; Kesharwani SS; Sangamwar AT
    J Mol Recognit; 2014 Mar; 27(3):138-50. PubMed ID: 24446378
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antitumour benzothiazoles. Part 15: The synthesis and physico-chemical properties of 2-(4-aminophenyl)benzothiazole sulfamate salt derivatives.
    Shi DF; Bradshaw TD; Chua MS; Westwell AD; Stevens MF
    Bioorg Med Chem Lett; 2001 Apr; 11(8):1093-5. PubMed ID: 11327598
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
    Bradshaw TD; Chua MS; Browne HL; Trapani V; Sausville EA; Stevens MF
    Br J Cancer; 2002 Apr; 86(8):1348-54. PubMed ID: 11953897
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the aryl hydrocarbon receptor.
    Bazzi R; Bradshaw TD; Rowlands JC; Stevens MF; Bell DR
    Toxicol Appl Pharmacol; 2009 May; 237(1):102-10. PubMed ID: 19265716
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
    Loaiza-Pérez AI; Trapani V; Hose C; Singh SS; Trepel JB; Stevens MF; Bradshaw TD; Sausville EA
    Mol Pharmacol; 2002 Jan; 61(1):13-9. PubMed ID: 11752201
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.