BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

252 related articles for article (PubMed ID: 12927546)

  • 1. Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site.
    Szabó E; Venekei I; Böcskei Z; Náray-Szabó G; Gráf L
    J Mol Biol; 2003 Aug; 331(5):1121-30. PubMed ID: 12927546
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
    Kaslik G; Westler WM; Gráf L; Markley JL
    Arch Biochem Biophys; 1999 Feb; 362(2):254-64. PubMed ID: 9989934
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The crystal structure of a trypsin-like mutant chymotrypsin: the role of position 226 in the activity and specificity of S189D chymotrypsin.
    Jelinek B; Katona G; Fodor K; Venekei I; Gráf L
    Protein J; 2008 Feb; 27(2):79-87. PubMed ID: 17805946
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease.
    Jelinek B; Antal J; Venekei I; Gráf L
    Protein Eng Des Sel; 2004 Feb; 17(2):127-31. PubMed ID: 15047908
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Attempts to convert chymotrypsin to trypsin.
    Venekei I; Szilágyi L; Gráf L; Rutter WJ
    FEBS Lett; 1996 Mar; 383(1-2):143-7. PubMed ID: 8612781
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases.
    Hedstrom L; Lin TY; Fast W
    Biochemistry; 1996 Apr; 35(14):4515-23. PubMed ID: 8605201
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Attempts to convert chymotrypsin to trypsin.
    Venekei I; Szilágyi L; Gráf L; Rutter WJ
    FEBS Lett; 1996 Jan; 379(2):143-7. PubMed ID: 8635580
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant.
    Hedstrom L; Perona JJ; Rutter WJ
    Biochemistry; 1994 Jul; 33(29):8757-63. PubMed ID: 8038165
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Converting trypsin to chymotrypsin: structural determinants of S1' specificity.
    Kurth T; Ullmann D; Jakubke HD; Hedstrom L
    Biochemistry; 1997 Aug; 36(33):10098-104. PubMed ID: 9254605
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
    Helland R; Czapinska H; Leiros I; Olufsen M; Otlewski J; Smalås AO
    J Mol Biol; 2003 Oct; 333(4):845-61. PubMed ID: 14568540
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
    Szabó A; Ludwig M; Hegyi E; Szépeová R; Witt H; Sahin-Tóth M
    J Biol Chem; 2015 Jul; 290(28):17282-92. PubMed ID: 26013824
    [TBL] [Abstract][Full Text] [Related]  

  • 12. New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.
    Jing H; Xu Y; Carson M; Moore D; Macon KJ; Volanakis JE; Narayana SV
    EMBO J; 2000 Jan; 19(2):164-73. PubMed ID: 10637221
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Converting trypsin to chymotrypsin: the role of surface loops.
    Hedstrom L; Szilagyi L; Rutter WJ
    Science; 1992 Mar; 255(5049):1249-53. PubMed ID: 1546324
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease.
    Szabó E; Böcskei Z; Náray-Szabó G; Gráf L
    Eur J Biochem; 1999 Jul; 263(1):20-6. PubMed ID: 10429182
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen.
    Pasternak A; Liu X; Lin TY; Hedstrom L
    Biochemistry; 1998 Nov; 37(46):16201-10. PubMed ID: 9819212
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
    Perona JJ; Hedstrom L; Wagner RL; Rutter WJ; Craik CS; Fletterick RJ
    Biochemistry; 1994 Mar; 33(11):3252-9. PubMed ID: 8136360
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
    Scheidig AJ; Hynes TR; Pelletier LA; Wells JA; Kossiakoff AA
    Protein Sci; 1997 Sep; 6(9):1806-24. PubMed ID: 9300481
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Trypsin: a case study in the structural determinants of enzyme specificity.
    Hedstrom L
    Biol Chem; 1996; 377(7-8):465-70. PubMed ID: 8922280
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity.
    Hedstrom L; Farr-Jones S; Kettner CA; Rutter WJ
    Biochemistry; 1994 Jul; 33(29):8764-9. PubMed ID: 8038166
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of the insertion loop around tryptophan 148 in tthe activity of thrombin.
    DiBella EE; Scheraga HA
    Biochemistry; 1996 Apr; 35(14):4427-33. PubMed ID: 8605192
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.