BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 12948851)

  • 1. Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
    Chow KU; Nowak D; Boehrer S; Ruthardt M; Knau A; Hoelzer D; Mitrou PS; Weidmann E
    Biochem Pharmacol; 2003 Sep; 66(5):711-24. PubMed ID: 12948851
    [TBL] [Abstract][Full Text] [Related]  

  • 2. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).
    Ng CP; Bonavida B
    Mol Cancer Ther; 2002 Oct; 1(12):1051-8. PubMed ID: 12481428
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.
    Boehrer S; Chow KU; Beske F; Kukoc-Zivojnov N; Puccetti E; Ruthardt M; Baum C; Rangnekar VM; Hoelzer D; Mitrou PS; Weidmann E
    Cancer Res; 2002 Mar; 62(6):1768-75. PubMed ID: 11912153
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
    Brieger A; Boehrer S; Schaaf S; Nowak D; Ruthardt M; Kim SZ; Atadja P; Hoelzer D; Mitrou PS; Weidmann E; Chow KU
    Biochem Pharmacol; 2004 Jul; 68(1):85-93. PubMed ID: 15183120
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
    Srinivasula SM; Datta P; Fan XJ; Fernandes-Alnemri T; Huang Z; Alnemri ES
    J Biol Chem; 2000 Nov; 275(46):36152-7. PubMed ID: 10950947
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: role of XIAP in resistance.
    Ng CP; Zisman A; Bonavida B
    Prostate; 2002 Dec; 53(4):286-99. PubMed ID: 12430140
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
    Chow KU; Sommerlad WD; Boehrer S; Schneider B; Seipelt G; Rummel MJ; Hoelzer D; Mitrou PS; Weidmann E
    Haematologica; 2002 Jan; 87(1):33-43. PubMed ID: 11801463
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
    Wu SJ; Ng LT; Lin CC
    Eur J Pharmacol; 2005 Aug; 518(2-3):96-106. PubMed ID: 16054126
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ.
    Arnt CR; Chiorean MV; Heldebrant MP; Gores GJ; Kaufmann SH
    J Biol Chem; 2002 Nov; 277(46):44236-43. PubMed ID: 12218061
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.
    Boehrer S; Nowak D; Hochmuth S; Kim SZ; Trepohl B; Afkir A; Hoelzer D; Mitrou PS; Weidmann E; Chow KU
    Cell Signal; 2005 May; 17(5):581-95. PubMed ID: 15683733
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Reovirus-induced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels.
    Kominsky DJ; Bickel RJ; Tyler KL
    J Virol; 2002 Nov; 76(22):11414-24. PubMed ID: 12388702
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins.
    Boehrer S; Nowak D; Schaaf S; Bergmann M; Brieger A; Hoelzer D; Mitrou PS; Weidmann E; Chow KU
    Hematol J; 2004; 5(6):513-8. PubMed ID: 15570294
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
    Rosato RR; Dai Y; Almenara JA; Maggio SC; Grant S
    Leukemia; 2004 Nov; 18(11):1780-8. PubMed ID: 15385934
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.
    Zhang XD; Zhang XY; Gray CP; Nguyen T; Hersey P
    Cancer Res; 2001 Oct; 61(19):7339-48. PubMed ID: 11585775
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma.
    Alas S; Ng CP; Bonavida B
    Clin Cancer Res; 2002 Mar; 8(3):836-45. PubMed ID: 11895917
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.
    Pardo OE; Lesay A; Arcaro A; Lopes R; Ng BL; Warne PH; McNeish IA; Tetley TD; Lemoine NR; Mehmet H; Seckl MJ; Downward J
    Mol Cell Biol; 2003 Nov; 23(21):7600-10. PubMed ID: 14560006
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
    Yang L; Mashima T; Sato S; Mochizuki M; Sakamoto H; Yamori T; Oh-Hara T; Tsuruo T
    Cancer Res; 2003 Feb; 63(4):831-7. PubMed ID: 12591734
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
    Adrain C; Creagh EM; Martin SJ
    EMBO J; 2001 Dec; 20(23):6627-36. PubMed ID: 11726499
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In AML cell lines Ara-C combined with purine analogues is able to exert synergistic as well as antagonistic effects on proliferation, apoptosis and disruption of mitochondrial membrane potential.
    Chow KU; Boehrer S; Napieralski S; Nowak D; Knau A; Hoelzer D; Mitrou PS; Weidmann E
    Leuk Lymphoma; 2003 Jan; 44(1):165-73. PubMed ID: 12691159
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine.
    Chow KU; Boehrer S; Geduldig K; Krapohl A; Hoelzer D; Mitrou PS; Weidmann E
    Haematologica; 2001 May; 86(5):485-93. PubMed ID: 11410411
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.