285 related articles for article (PubMed ID: 12950260)
1. Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Di Marco A; Yao D; Laufer R
Eur J Biochem; 2003 Sep; 270(18):3768-77. PubMed ID: 12950260
[TBL] [Abstract][Full Text] [Related]
2. Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Schmider J; Greenblatt DJ; Fogelman SM; von Moltke LL; Shader RI
Biopharm Drug Dispos; 1997 Apr; 18(3):227-40. PubMed ID: 9113345
[TBL] [Abstract][Full Text] [Related]
3. Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
Brown HS; Chadwick A; Houston JB
Drug Metab Dispos; 2007 Nov; 35(11):2119-26. PubMed ID: 17724064
[TBL] [Abstract][Full Text] [Related]
4. Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes.
Kerry NL; Somogyi AA; Mikus G; Bochner F
Biochem Pharmacol; 1993 Feb; 45(4):833-9. PubMed ID: 8452558
[TBL] [Abstract][Full Text] [Related]
5. The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Madeira M; Levine M; Chang TK; Mirfazaelian A; Bellward GD
Drug Metab Dispos; 2004 Apr; 32(4):460-7. PubMed ID: 16680870
[TBL] [Abstract][Full Text] [Related]
6. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
Eagling VA; Tjia JF; Back DJ
Br J Clin Pharmacol; 1998 Feb; 45(2):107-14. PubMed ID: 9491822
[TBL] [Abstract][Full Text] [Related]
7. The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.
Daniel WA; Syrek M; Haduch A
Eur Neuropsychopharmacol; 2002 Oct; 12(5):371-7. PubMed ID: 12208554
[TBL] [Abstract][Full Text] [Related]
8. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.
BourriƩ M; Meunier V; Berger Y; Fabre G
J Pharmacol Exp Ther; 1996 Apr; 277(1):321-32. PubMed ID: 8613937
[TBL] [Abstract][Full Text] [Related]
9. UPLC-MS/MS analysis of dextromethorphan-O-demethylation kinetics in rat brain microsomes.
DuBois BN; Mehvar R
J Chromatogr B Analyt Technol Biomed Life Sci; 2018 Oct; 1096():66-72. PubMed ID: 30149296
[TBL] [Abstract][Full Text] [Related]
10. Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
Zhao XJ; Kawashiro T; Ishizaki T
Drug Metab Dispos; 1998 Feb; 26(2):188-91. PubMed ID: 9456308
[TBL] [Abstract][Full Text] [Related]
11. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
Obach RS
Drug Metab Dispos; 2000 Sep; 28(9):1069-76. PubMed ID: 10950851
[TBL] [Abstract][Full Text] [Related]
12. The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Kerry NL; Somogyi AA; Bochner F; Mikus G
Br J Clin Pharmacol; 1994 Sep; 38(3):243-8. PubMed ID: 7826826
[TBL] [Abstract][Full Text] [Related]
13. [Metabolites and metabolic pathways of mesaconitine in rat liver microsomal investigated by using UPLC-MS/MS method in vitro].
Bi YF; Liu S; Zhang RX; Song FR; Liu ZQ
Yao Xue Xue Bao; 2013 Dec; 48(12):1823-8. PubMed ID: 24689241
[TBL] [Abstract][Full Text] [Related]
14. Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA.
Giri P; Delvadia P; Gupta L; Patel N; Trivedi P; Lad K; Patel HM; Srinivas NR
Xenobiotica; 2018 Jan; 48(1):1-10. PubMed ID: 28010169
[TBL] [Abstract][Full Text] [Related]
15. The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach.
Delaporte E; Slaughter DE; Egan MA; Gatto GJ; Santos A; Shelley J; Price E; Howells L; Dean DC; Rodrigues AD
J Biomol Screen; 2001 Aug; 6(4):225-31. PubMed ID: 11689122
[TBL] [Abstract][Full Text] [Related]
16. Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential.
Moody GC; Griffin SJ; Mather AN; McGinnity DF; Riley RJ
Xenobiotica; 1999 Jan; 29(1):53-75. PubMed ID: 10078840
[TBL] [Abstract][Full Text] [Related]
17. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat.
Witherow LE; Houston JB
J Pharmacol Exp Ther; 1999 Jul; 290(1):58-65. PubMed ID: 10381760
[TBL] [Abstract][Full Text] [Related]
18. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
Hesse LM; Venkatakrishnan K; von Moltke LL; Shader RI; Greenblatt DJ
Drug Metab Dispos; 2001 Feb; 29(2):133-40. PubMed ID: 11159802
[TBL] [Abstract][Full Text] [Related]
19. Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily.
Gorski JC; Jones DR; Hamman MA; Wrighton SA; Hall SD
Xenobiotica; 1999 Sep; 29(9):931-44. PubMed ID: 10548453
[TBL] [Abstract][Full Text] [Related]
20. Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen.
Miners JO; Coulter S; Tukey RH; Veronese ME; Birkett DJ
Biochem Pharmacol; 1996 Apr; 51(8):1003-8. PubMed ID: 8866821
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]