343 related articles for article (PubMed ID: 12952921)
1. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
Alp NJ; Mussa S; Khoo J; Cai S; Guzik T; Jefferson A; Goh N; Rockett KA; Channon KM
J Clin Invest; 2003 Sep; 112(5):725-35. PubMed ID: 12952921
[TBL] [Abstract][Full Text] [Related]
2. Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Bendall JK; Alp NJ; Warrick N; Cai S; Adlam D; Rockett K; Yokoyama M; Kawashima S; Channon KM
Circ Res; 2005 Oct; 97(9):864-71. PubMed ID: 16179591
[TBL] [Abstract][Full Text] [Related]
3. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM
Arterioscler Thromb Vasc Biol; 2004 Mar; 24(3):445-50. PubMed ID: 14707037
[TBL] [Abstract][Full Text] [Related]
4. GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.
Tie L; Chen LY; Chen DD; Xie HH; Channon KM; Chen AF
Am J Physiol Endocrinol Metab; 2014 May; 306(10):E1120-31. PubMed ID: 24644242
[TBL] [Abstract][Full Text] [Related]
5. Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
Adlam D; Bendall JK; De Bono JP; Alp NJ; Khoo J; Nicoli T; Yokoyama M; Kawashima S; Channon KM
Exp Physiol; 2007 Jan; 92(1):119-26. PubMed ID: 17012144
[TBL] [Abstract][Full Text] [Related]
6. Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
Du YH; Guan YY; Alp NJ; Channon KM; Chen AF
Circulation; 2008 Feb; 117(8):1045-54. PubMed ID: 18268143
[TBL] [Abstract][Full Text] [Related]
7. Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.
Santhanam AV; d'Uscio LV; Katusic ZS
Brain Res; 2015 Nov; 1625():198-205. PubMed ID: 26343845
[TBL] [Abstract][Full Text] [Related]
8. Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
Crabtree MJ; Tatham AL; Al-Wakeel Y; Warrick N; Hale AB; Cai S; Channon KM; Alp NJ
J Biol Chem; 2009 Jan; 284(2):1136-44. PubMed ID: 19011239
[TBL] [Abstract][Full Text] [Related]
9. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Chuaiphichai S; McNeill E; Douglas G; Crabtree MJ; Bendall JK; Hale AB; Alp NJ; Channon KM
Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
[TBL] [Abstract][Full Text] [Related]
10. Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
Tie L; Li XJ; Wang X; Channon KM; Chen AF
Am J Physiol Endocrinol Metab; 2009 Jun; 296(6):E1423-9. PubMed ID: 19336662
[TBL] [Abstract][Full Text] [Related]
11. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
Crabtree MJ; Tatham AL; Hale AB; Alp NJ; Channon KM
J Biol Chem; 2009 Oct; 284(41):28128-28136. PubMed ID: 19666465
[TBL] [Abstract][Full Text] [Related]
12. Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.
Schäfer A; Alp NJ; Cai S; Lygate CA; Neubauer S; Eigenthaler M; Bauersachs J; Channon KM
Arterioscler Thromb Vasc Biol; 2004 Sep; 24(9):1720-6. PubMed ID: 15242858
[TBL] [Abstract][Full Text] [Related]
13. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
Xie HH; Zhou S; Chen DD; Channon KM; Su DF; Chen AF
Hypertension; 2010 Dec; 56(6):1137-44. PubMed ID: 21059996
[TBL] [Abstract][Full Text] [Related]
14. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.
Sugiyama T; Levy BD; Michel T
J Biol Chem; 2009 May; 284(19):12691-700. PubMed ID: 19286667
[TBL] [Abstract][Full Text] [Related]
15. Apolipoprotein A-I mimetic peptide inhibits atherosclerosis by increasing tetrahydrobiopterin via regulation of GTP-cyclohydrolase 1 and reducing uncoupled endothelial nitric oxide synthase activity.
Ning DS; Ma J; Peng YM; Li Y; Chen YT; Li SX; Liu Z; Li YQ; Zhang YX; Jian YP; Ou ZJ; Ou JS
Atherosclerosis; 2021 Jul; 328():83-91. PubMed ID: 34118596
[TBL] [Abstract][Full Text] [Related]
16. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Alp NJ; Channon KM
Arterioscler Thromb Vasc Biol; 2004 Mar; 24(3):413-20. PubMed ID: 14656731
[TBL] [Abstract][Full Text] [Related]
17. Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Sasaki N; Yamashita T; Takaya T; Shinohara M; Shiraki R; Takeda M; Emoto N; Fukatsu A; Hayashi T; Ikemoto K; Nomura T; Yokoyama M; Hirata K; Kawashima S
Arterioscler Thromb Vasc Biol; 2008 Jun; 28(6):1068-76. PubMed ID: 18403727
[TBL] [Abstract][Full Text] [Related]
18. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
Cai S; Khoo J; Channon KM
Cardiovasc Res; 2005 Mar; 65(4):823-31. PubMed ID: 15721862
[TBL] [Abstract][Full Text] [Related]
19. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
Cai S; Alp NJ; McDonald D; Smith I; Kay J; Canevari L; Heales S; Channon KM
Cardiovasc Res; 2002 Sep; 55(4):838-49. PubMed ID: 12176133
[TBL] [Abstract][Full Text] [Related]
20. Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
Shimizu S; Shiota K; Yamamoto S; Miyasaka Y; Ishii M; Watabe T; Nishida M; Mori Y; Yamamoto T; Kiuchi Y
Free Radic Biol Med; 2003 May; 34(10):1343-52. PubMed ID: 12726922
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]