127 related articles for article (PubMed ID: 12953217)
1. Structure-activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding affinity and topoisomerase II inhibition.
Bielawska A; Bielawski K; Wołczyński S; Anchim T
Arch Pharm (Weinheim); 2003 Aug; 336(6-7):293-9. PubMed ID: 12953217
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Kim MY; Duan W; Gleason-Guzman M; Hurley LH
J Med Chem; 2003 Feb; 46(4):571-83. PubMed ID: 12570378
[TBL] [Abstract][Full Text] [Related]
4. Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Anizon F; Belin L; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Sevère D; Riou JF; Bailly C; Fabbro D; Meyer T
J Med Chem; 1997 Oct; 40(21):3456-65. PubMed ID: 9341921
[TBL] [Abstract][Full Text] [Related]
5. Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Guan J; Zhu XK; Tachibana Y; Bastow KF; Brossi A; Hamel E; Lee KH
J Med Chem; 1998 May; 41(11):1956-61. PubMed ID: 9599244
[TBL] [Abstract][Full Text] [Related]
6. Relationships between topoisomerase II inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives.
Bailly C; Dassonneville L; Carrasco C; Lucas D; Kumar A; Boykin DW; Wilson WD
Anticancer Drug Des; 1999 Feb; 14(1):47-60. PubMed ID: 10363027
[TBL] [Abstract][Full Text] [Related]
7. L-proline analogues of anthraquinone-2-carboxylic acid: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II.
Bielawska A; Kosk K; Bielawski K
Pol J Pharmacol; 2001; 53(3):283-7. PubMed ID: 11785929
[TBL] [Abstract][Full Text] [Related]
8. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
[TBL] [Abstract][Full Text] [Related]
9. Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
Cho SJ; Kashiwada Y; Bastow KF; Cheng YC; Lee KH
J Med Chem; 1996 Mar; 39(7):1396-402. PubMed ID: 8691469
[TBL] [Abstract][Full Text] [Related]
10. Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.
Rothenborg-Jensen L; Hansen HF; Wessel I; Nitiss JL; Schmidt G; Jensen PB; Sehested M; Jensen LH
Anticancer Drug Des; 2001 Dec; 16(6):305-15. PubMed ID: 12375883
[TBL] [Abstract][Full Text] [Related]
11. Topoisomerase II poisoning and antineoplastic action by DNA-nonbinding diacetyl and dicarboxaldoxime derivatives of ferrocene.
Vashisht Gopal YN; Jayaraju D; Kondapi AK
Arch Biochem Biophys; 2000 Apr; 376(1):229-35. PubMed ID: 10729210
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents.
Lee M; Rhodes AL; Wyatt MD; Forrow S; Hartley JA
Anticancer Drug Des; 1993 Jun; 8(3):173-92. PubMed ID: 8517912
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
Perni RB; Wentland MP; Huang JI; Powles RG; Aldous S; Klingbeil KM; Peverly AD; Robinson RG; Corbett TH; Jones JL; Mattes KC; Rake JB; Coughlin SA
J Med Chem; 1998 Sep; 41(19):3645-54. PubMed ID: 9733489
[TBL] [Abstract][Full Text] [Related]
14. Methoxy- and methyl-, methoxy-5,6,11-trimethyl-6H-indolo [2,3-b]quinolinium derivatives as novel cytotoxic agents and DNA topoisomerase II inhibitors.
Kaczmarek L; Peczyńska-Czoch W; Opolski A; Wietrzyk J; Marcinkowska E; Boratyński J; Osiadacz J
Anticancer Res; 1998; 18(4C):3133-8. PubMed ID: 9713522
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis and topoisomerase II inhibition activity of 4'-demethylepipodophyllotoxin-lexitropsin conjugates.
Gupta R; al-Said NH; Oreski B; Lown JW
Anticancer Drug Des; 1996 Jun; 11(4):325-38. PubMed ID: 8679055
[TBL] [Abstract][Full Text] [Related]
16. Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.
Wyatt MD; Garbiras BJ; Haskell MK; Lee M; Souhami RL; Hartley JA
Anticancer Drug Des; 1994 Dec; 9(6):511-25. PubMed ID: 7880376
[TBL] [Abstract][Full Text] [Related]
17. Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)].
Vashisht Gopal YN; Konuru N; Kondapi AK
Arch Biochem Biophys; 2002 May; 401(1):53-62. PubMed ID: 12054487
[TBL] [Abstract][Full Text] [Related]
18. Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
Skibo EB; Gordon S; Bess L; Boruah R; Heileman MJ
J Med Chem; 1997 Apr; 40(9):1327-39. PubMed ID: 9135030
[TBL] [Abstract][Full Text] [Related]
19. Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Lansiaux A; Tanious F; Mishal Z; Dassonneville L; Kumar A; Stephens CE; Hu Q; Wilson WD; Boykin DW; Bailly C
Cancer Res; 2002 Dec; 62(24):7219-29. PubMed ID: 12499262
[TBL] [Abstract][Full Text] [Related]
20. Topoisomerase I/II selectivity among derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).
Bridewell DJ; Finlay GJ; Baguley BC
Anticancer Drug Des; 2001 Dec; 16(6):317-24. PubMed ID: 12375884
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
