203 related articles for article (PubMed ID: 12963370)
1. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.
DiDonato M; Craig L; Huff ME; Thayer MM; Cardoso RM; Kassmann CJ; Lo TP; Bruns CK; Powers ET; Kelly JW; Getzoff ED; Tainer JA
J Mol Biol; 2003 Sep; 332(3):601-15. PubMed ID: 12963370
[TBL] [Abstract][Full Text] [Related]
2. Comparative structural and conformational studies on H43R and W32F mutants of copper-zinc superoxide dismutase by molecular dynamics simulation.
Muneeswaran G; Kartheeswaran S; Muthukumar K; Dharmaraj CD; Karunakaran C
Biophys Chem; 2014 Jan; 185():70-8. PubMed ID: 24369116
[TBL] [Abstract][Full Text] [Related]
3. Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase.
Strange RW; Yong CW; Smith W; Hasnain SS
Proc Natl Acad Sci U S A; 2007 Jun; 104(24):10040-4. PubMed ID: 17548825
[TBL] [Abstract][Full Text] [Related]
4. Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
Roberts BR; Tainer JA; Getzoff ED; Malencik DA; Anderson SR; Bomben VC; Meyers KR; Karplus PA; Beckman JS
J Mol Biol; 2007 Nov; 373(4):877-90. PubMed ID: 17888947
[TBL] [Abstract][Full Text] [Related]
5. Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.
Schmidlin T; Kennedy BK; Daggett V
Biophys J; 2009 Sep; 97(6):1709-18. PubMed ID: 19751676
[TBL] [Abstract][Full Text] [Related]
6. An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.
Ray SS; Nowak RJ; Strokovich K; Brown RH; Walz T; Lansbury PT
Biochemistry; 2004 May; 43(17):4899-905. PubMed ID: 15109247
[TBL] [Abstract][Full Text] [Related]
7. Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants.
Khare SD; Dokholyan NV
Proc Natl Acad Sci U S A; 2006 Feb; 103(9):3147-52. PubMed ID: 16488975
[TBL] [Abstract][Full Text] [Related]
8. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Deng HX; Hentati A; Tainer JA; Iqbal Z; Cayabyab A; Hung WY; Getzoff ED; Hu P; Herzfeldt B; Roos RP
Science; 1993 Aug; 261(5124):1047-51. PubMed ID: 8351519
[TBL] [Abstract][Full Text] [Related]
9. Cu/Zn superoxide dismutase can form pore-like structures.
Chung J; Yang H; de Beus MD; Ryu CY; Cho K; Colón W
Biochem Biophys Res Commun; 2003 Dec; 312(4):873-6. PubMed ID: 14651952
[TBL] [Abstract][Full Text] [Related]
10. Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro.
Stathopulos PB; Rumfeldt JA; Scholz GA; Irani RA; Frey HE; Hallewell RA; Lepock JR; Meiering EM
Proc Natl Acad Sci U S A; 2003 Jun; 100(12):7021-6. PubMed ID: 12773627
[TBL] [Abstract][Full Text] [Related]
11. Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS.
Elam JS; Taylor AB; Strange R; Antonyuk S; Doucette PA; Rodriguez JA; Hasnain SS; Hayward LJ; Valentine JS; Yeates TO; Hart PJ
Nat Struct Biol; 2003 Jun; 10(6):461-7. PubMed ID: 12754496
[TBL] [Abstract][Full Text] [Related]
12. FALS mutations in Cu, Zn superoxide dismutase destabilize the dimer and increase dimer dissociation propensity: a large-scale thermodynamic analysis.
Khare SD; Caplow M; Dokholyan NV
Amyloid; 2006 Dec; 13(4):226-35. PubMed ID: 17107883
[TBL] [Abstract][Full Text] [Related]
13. Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.
Pratt AJ; Shin DS; Merz GE; Rambo RP; Lancaster WA; Dyer KN; Borbat PP; Poole FL; Adams MW; Freed JH; Crane BR; Tainer JA; Getzoff ED
Proc Natl Acad Sci U S A; 2014 Oct; 111(43):E4568-76. PubMed ID: 25316790
[TBL] [Abstract][Full Text] [Related]
14. Kinetic stability of Cu/Zn superoxide dismutase is dependent on its metal ligands: implications for ALS.
Lynch SM; Boswell SA; Colón W
Biochemistry; 2004 Dec; 43(51):16525-31. PubMed ID: 15610047
[TBL] [Abstract][Full Text] [Related]
15. Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.
Cardoso RM; Thayer MM; DiDonato M; Lo TP; Bruns CK; Getzoff ED; Tainer JA
J Mol Biol; 2002 Nov; 324(2):247-56. PubMed ID: 12441104
[TBL] [Abstract][Full Text] [Related]
16. Local destabilization of the metal-binding region in human copper-zinc superoxide dismutase by remote mutations is a possible determinant for progression of ALS.
Hennig J; Andrésen C; Museth AK; Lundström P; Tibell LA; Jonsson BH
Biochemistry; 2015 Jan; 54(2):323-33. PubMed ID: 25496420
[TBL] [Abstract][Full Text] [Related]
17. Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.
Ray SS; Nowak RJ; Brown RH; Lansbury PT
Proc Natl Acad Sci U S A; 2005 Mar; 102(10):3639-44. PubMed ID: 15738401
[TBL] [Abstract][Full Text] [Related]
18. The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.
Strange RW; Antonyuk S; Hough MA; Doucette PA; Rodriguez JA; Hart PJ; Hayward LJ; Valentine JS; Hasnain SS
J Mol Biol; 2003 May; 328(4):877-91. PubMed ID: 12729761
[TBL] [Abstract][Full Text] [Related]
19. Accelerated s-nitrosothiol breakdown by amyotrophic lateral sclerosis mutant copper,zinc-superoxide dismutase.
Johnson MA; Macdonald TL; Mannick JB; Conaway MR; Gaston B
J Biol Chem; 2001 Oct; 276(43):39872-8. PubMed ID: 11518706
[TBL] [Abstract][Full Text] [Related]
20. CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.
Farrawell NE; Yerbury MR; Plotkin SS; McAlary L; Yerbury JJ
ACS Chem Neurosci; 2019 Mar; 10(3):1555-1564. PubMed ID: 30462490
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
