222 related articles for article (PubMed ID: 12963486)
1. Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania.
El-Fadili A; Richard D; Kündig C; Ouellette M
Biochem Pharmacol; 2003 Sep; 66(6):999-1008. PubMed ID: 12963486
[TBL] [Abstract][Full Text] [Related]
2. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
[TBL] [Abstract][Full Text] [Related]
3. Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania.
El Fadili A; Kündig C; Ouellette M
Mol Biochem Parasitol; 2002; 124(1-2):63-71. PubMed ID: 12387851
[TBL] [Abstract][Full Text] [Related]
4. Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate.
El Fadili A; Kündig C; Roy G; Ouellette M
J Biol Chem; 2004 Apr; 279(18):18575-82. PubMed ID: 14981076
[TBL] [Abstract][Full Text] [Related]
5. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
Qi H; Atkinson I; Xiao S; Choi YJ; Tobimatsu T; Shane B
Adv Enzyme Regul; 1999; 39():263-73. PubMed ID: 10470377
[TBL] [Abstract][Full Text] [Related]
6. Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells.
Cho RC; Cole PD; Sohn KJ; Gaisano G; Croxford R; Kamen BA; Kim YI
Mol Cancer Ther; 2007 Nov; 6(11):2909-20. PubMed ID: 18025275
[TBL] [Abstract][Full Text] [Related]
7. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Stark M; Wichman C; Avivi I; Assaraf YG
Blood; 2009 Apr; 113(18):4362-9. PubMed ID: 19131550
[TBL] [Abstract][Full Text] [Related]
8. Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Raz S; Stark M; Assaraf YG
Drug Resist Updat; 2016 Sep; 28():43-64. PubMed ID: 27620954
[TBL] [Abstract][Full Text] [Related]
9. Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.
Sohn KJ; Smirnakis F; Moskovitz DN; Novakovic P; Yates Z; Lucock M; Croxford R; Kim YI
Gut; 2004 Dec; 53(12):1825-31. PubMed ID: 15542523
[TBL] [Abstract][Full Text] [Related]
10. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Mauritz R; Peters GJ; Priest DG; Assaraf YG; Drori S; Kathmann I; Noordhuis P; Bunni MA; Rosowsky A; Schornagel JH; Pinedo HM; Jansen G
Biochem Pharmacol; 2002 Jan; 63(2):105-15. PubMed ID: 11841783
[TBL] [Abstract][Full Text] [Related]
11. In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate.
van der Laan BF; Jansen G; Kathmann GA; Westerhof GR; Schornagel JH; Hordijk GJ
Int J Cancer; 1992 Jul; 51(6):909-14. PubMed ID: 1639538
[TBL] [Abstract][Full Text] [Related]
12. Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity.
Kim JS; Lowe KE; Shane B
J Biol Chem; 1993 Oct; 268(29):21680-5. PubMed ID: 8408021
[TBL] [Abstract][Full Text] [Related]
13. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
Matherly LH; Angeles SM; McGuire JJ
Biochem Pharmacol; 1993 Dec; 46(12):2185-95. PubMed ID: 7506026
[TBL] [Abstract][Full Text] [Related]
14. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.
Kündig C; Haimeur A; Légaré D; Papadopoulou B; Ouellette M
EMBO J; 1999 May; 18(9):2342-51. PubMed ID: 10228149
[TBL] [Abstract][Full Text] [Related]
15. Folate analogues as substrates of mammalian folylpolyglutamate synthetase.
Schoo MM; Pristupa ZB; Vickers PJ; Scrimgeour KG
Cancer Res; 1985 Jul; 45(7):3034-41. PubMed ID: 3873989
[TBL] [Abstract][Full Text] [Related]
16. Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
McGuire JJ; Heitzman KJ; Haile WH; Russell CA; McCloskey DE; Piper JR
Leukemia; 1993 Dec; 7(12):1996-2003. PubMed ID: 8255099
[TBL] [Abstract][Full Text] [Related]
17. Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines.
McGuire JJ; Russell CA
Oncol Res; 1998; 10(4):193-200. PubMed ID: 9778690
[TBL] [Abstract][Full Text] [Related]
18. gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Longo GS; Gorlick R; Tong WP; Lin S; Steinherz P; Bertino JR
Oncol Res; 1997; 9(5):259-63. PubMed ID: 9306433
[TBL] [Abstract][Full Text] [Related]
19. Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Rots MG; Pieters R; Peters GJ; Noordhuis P; van Zantwijk CH; Kaspers GJ; Hählen K; Creutzig U; Veerman AJ; Jansen G
Blood; 1999 Mar; 93(5):1677-83. PubMed ID: 10029597
[TBL] [Abstract][Full Text] [Related]
20. Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists.
Clarke L; Waxman DJ
Arch Biochem Biophys; 1987 Aug; 256(2):585-96. PubMed ID: 3619447
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
