These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 12963818)

  • 21. Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
    Wessel I; Jensen LH; Renodon-Corniere A; Sorensen TK; Nitiss JL; Jensen PB; Sehested M
    FEBS Lett; 2002 Jun; 520(1-3):161-6. PubMed ID: 12044890
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle.
    Sehested M; Jensen PB
    Biochem Pharmacol; 1996 Apr; 51(7):879-86. PubMed ID: 8651936
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy.
    Martin E; Thougaard AV; Grauslund M; Jensen PB; Bjorkling F; Hasinoff BB; Tjørnelund J; Sehested M; Jensen LH
    Toxicology; 2009 Jan; 255(1-2):72-9. PubMed ID: 19010377
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability.
    West KL; Turnbull RM; Willmore E; Lakey JH; Austin CA
    Nucleic Acids Res; 2002 Dec; 30(24):5416-24. PubMed ID: 12490710
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.
    Chang S; Hu T; Hsieh TS
    J Biol Chem; 1998 Jul; 273(31):19822-8. PubMed ID: 9677416
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Steady-state and rapid kinetic analysis of topoisomerase II trapped as the closed-clamp intermediate by ICRF-193.
    Morris SK; Baird CL; Lindsley JE
    J Biol Chem; 2000 Jan; 275(4):2613-8. PubMed ID: 10644721
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.
    Hasinoff BB; Creighton AM; Kozlowska H; Thampatty P; Allan WP; Yalowich JC
    Mol Pharmacol; 1997 Nov; 52(5):839-45. PubMed ID: 9351975
    [TBL] [Abstract][Full Text] [Related]  

  • 28. N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance.
    Jensen LH; Wessel I; Møller M; Nitiss JL; Sehested M; Jensen PB
    FEBS Lett; 2000 Sep; 480(2-3):201-7. PubMed ID: 11034329
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Interaction of the DNA topoisomerase II catalytic inhibitor meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane (ICRF-193), a bisdioxopiperazine derivative, with the conserved region(s) of eukaryotic but not prokaryotic enzyme.
    Sato M; Ishida R; Narita T; Kato J; Ikeda H; Fukazawa H; Andoh T
    Biochem Pharmacol; 1997 Sep; 54(5):545-50. PubMed ID: 9337070
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
    Ling EM; Baslé A; Cowell IG; van den Berg B; Blower TR; Austin CA
    Structure; 2022 Aug; 30(8):1129-1145.e3. PubMed ID: 35660158
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Structure and mechanism of DNA topoisomerase II.
    Berger JM; Gamblin SJ; Harrison SC; Wang JC
    Nature; 1996 Jan; 379(6562):225-32. PubMed ID: 8538787
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Ku antigen is required to relieve G2 arrest caused by inhibition of DNA topoisomerase II activity by the bisdioxopiperazine ICRF-193.
    Muñoz P; Baus F; Piette J
    Oncogene; 2001 Apr; 20(16):1990-9. PubMed ID: 11360183
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
    Agrawal A; Roué M; Spitzfaden C; Petrella S; Aubry A; Hann M; Bax B; Mayer C
    Biochem J; 2013 Dec; 456(2):263-73. PubMed ID: 24015710
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.
    Wei H; Ruthenburg AJ; Bechis SK; Verdine GL
    J Biol Chem; 2005 Nov; 280(44):37041-7. PubMed ID: 16100112
    [TBL] [Abstract][Full Text] [Related]  

  • 35. The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.
    Hasinoff BB; Abram ME; Barnabé N; Khélifa T; Allan WP; Yalowich JC
    Mol Pharmacol; 2001 Mar; 59(3):453-61. PubMed ID: 11179439
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
    Nakazawa N; Arakawa O; Ebe M; Yanagida M
    J Biol Chem; 2019 Mar; 294(10):3772-3782. PubMed ID: 30635402
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center.
    Brino L; Urzhumtsev A; Mousli M; Bronner C; Mitschler A; Oudet P; Moras D
    J Biol Chem; 2000 Mar; 275(13):9468-75. PubMed ID: 10734094
    [TBL] [Abstract][Full Text] [Related]  

  • 38. ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
    Holm B; Jensen PB; Sehested M
    Cancer Chemother Pharmacol; 1996; 38(3):203-9. PubMed ID: 8646793
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide.
    Sengupta T; Mukherjee M; Das A; Mandal C; Das R; Mukherjee T; Majumder HK
    Biochem J; 2005 Sep; 390(Pt 2):419-26. PubMed ID: 15901238
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase.
    Kuang W; Zhao Y; Li J; Deng Z
    mBio; 2024 Apr; 15(4):e0308623. PubMed ID: 38411066
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.