200 related articles for article (PubMed ID: 12966028)
21. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
[TBL] [Abstract][Full Text] [Related]
22. Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
Fluhrer R; Haass C
Neurodegener Dis; 2007; 4(2-3):112-6. PubMed ID: 17596705
[TBL] [Abstract][Full Text] [Related]
23. Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
Alves da Costa C; Ayral E; Hernandez JF; St George-Hyslop P; Checler F
J Neurochem; 2004 Aug; 90(4):800-6. PubMed ID: 15287885
[TBL] [Abstract][Full Text] [Related]
24. Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP).
Schröder B; Saftig P
Biochem J; 2010 Apr; 427(3):e1-3. PubMed ID: 20388122
[TBL] [Abstract][Full Text] [Related]
25. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
26. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
[TBL] [Abstract][Full Text] [Related]
27. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
28. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.
Gowrishankar K; Zeidler MG; Vincenz C
J Cell Sci; 2004 Aug; 117(Pt 18):4099-111. PubMed ID: 15280425
[TBL] [Abstract][Full Text] [Related]
29. Biochemistry. Intramembrane proteases--mixing oil and water.
Wolfe MS; Selkoe DJ
Science; 2002 Jun; 296(5576):2156-7. PubMed ID: 12077393
[No Abstract] [Full Text] [Related]
30. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
Zhou S; Zhou H; Walian PJ; Jap BK
Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
[TBL] [Abstract][Full Text] [Related]
31. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
32. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
Oh YS; Turner RJ
Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
[TBL] [Abstract][Full Text] [Related]
33. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
Nyborg AC; Ladd TB; Jansen K; Kukar T; Golde TE
FASEB J; 2006 Aug; 20(10):1671-9. PubMed ID: 16873890
[TBL] [Abstract][Full Text] [Related]
34. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
[TBL] [Abstract][Full Text] [Related]
35. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
36. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
37. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
[TBL] [Abstract][Full Text] [Related]
38. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
39. [Pathogenesis of Alzheimer's disease: implications from amyloid research front].
Iwatsubo T
Rinsho Shinkeigaku; 2004 Nov; 44(11):768-70. PubMed ID: 15651286
[TBL] [Abstract][Full Text] [Related]
40. Intramembrane proteolysis: theme and variations.
Wolfe MS; Kopan R
Science; 2004 Aug; 305(5687):1119-23. PubMed ID: 15326347
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]