480 related articles for article (PubMed ID: 12975327)
1. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Jalas JR; Ding X; Murphy SE
Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
Jalas JR; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):782-93. PubMed ID: 12807362
[TBL] [Abstract][Full Text] [Related]
3. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
Wong HL; Zhang X; Zhang QY; Gu J; Ding X; Hecht SS; Murphy SE
Chem Res Toxicol; 2005 Jun; 18(6):913-8. PubMed ID: 15962925
[TBL] [Abstract][Full Text] [Related]
4. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
Felicia ND; Rekha GK; Murphy SE
Arch Biochem Biophys; 2000 Dec; 384(2):418-24. PubMed ID: 11368333
[TBL] [Abstract][Full Text] [Related]
5. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.
Richter E; Engl J; Friesenegger S; Tricker AR
Chem Res Toxicol; 2009 Jun; 22(6):1008-17. PubMed ID: 19408892
[TBL] [Abstract][Full Text] [Related]
6. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
Brown PJ; Bedard LL; Reid KR; Petsikas D; Massey TE
Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
[TBL] [Abstract][Full Text] [Related]
7. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Jalas JR; McIntee EJ; Kenney PM; Upadhyaya P; Peterson LA; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):794-806. PubMed ID: 12807363
[TBL] [Abstract][Full Text] [Related]
8. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Upadhyaya P; Kalscheuer S; Hochalter JB; Villalta PW; Hecht SS
Chem Res Toxicol; 2008 Jul; 21(7):1468-76. PubMed ID: 18570389
[TBL] [Abstract][Full Text] [Related]
9. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
Chiang HC; Wang CY; Lee HL; Tsou TC
Toxicol Appl Pharmacol; 2011 Jun; 253(2):145-52. PubMed ID: 21473878
[TBL] [Abstract][Full Text] [Related]
10. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
Staretz ME; Murphy SE; Patten CJ; Nunes MG; Koehl W; Amin S; Koenig LA; Guengerich FP; Hecht SS
Drug Metab Dispos; 1997 Feb; 25(2):154-62. PubMed ID: 9029045
[TBL] [Abstract][Full Text] [Related]
11. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.
Wong HL; Murphy SE; Hecht SS
Chem Res Toxicol; 2005 Jan; 18(1):61-9. PubMed ID: 15651850
[TBL] [Abstract][Full Text] [Related]
12. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
Smith TJ; Liao AM; Liu Y; Jones AB; Anderson LM; Yang CS
Carcinogenesis; 1997 Aug; 18(8):1577-84. PubMed ID: 9276633
[TBL] [Abstract][Full Text] [Related]
13. Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
von Weymarn LB; Chun JA; Hollenberg PF
Carcinogenesis; 2006 Apr; 27(4):782-90. PubMed ID: 16364922
[TBL] [Abstract][Full Text] [Related]
14. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats.
Guo Z; Smith TJ; Thomas PE; Yang CS
Arch Biochem Biophys; 1992 Oct; 298(1):279-86. PubMed ID: 1524438
[TBL] [Abstract][Full Text] [Related]
15. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Carmella SG; Borukhova A; Akerkar SA; Hecht SS
Cancer Epidemiol Biomarkers Prev; 1997 Feb; 6(2):113-20. PubMed ID: 9037562
[TBL] [Abstract][Full Text] [Related]
16. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes.
Collazo NR; Sultatos LG
Biochem Pharmacol; 1995 Nov; 50(11):1933-41. PubMed ID: 8615875
[TBL] [Abstract][Full Text] [Related]
17. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
[TBL] [Abstract][Full Text] [Related]
18. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue.
Doerr-O'Rourke K; Trushin N; Hecht SS; Stoner GD
Carcinogenesis; 1991 Jun; 12(6):1029-34. PubMed ID: 2044181
[TBL] [Abstract][Full Text] [Related]
19. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.
Maser E
Cancer Res; 1998 Jul; 58(14):2996-3003. PubMed ID: 9679962
[TBL] [Abstract][Full Text] [Related]
20. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Zhang S; Wang M; Villalta PW; Lindgren BR; Upadhyaya P; Lao Y; Hecht SS
Chem Res Toxicol; 2009 May; 22(5):926-36. PubMed ID: 19358518
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
