BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 12975377)

  • 21. TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.
    Sakurai H; Nishi A; Sato N; Mizukami J; Miyoshi H; Sugita T
    Biochem Biophys Res Commun; 2002 Oct; 297(5):1277-81. PubMed ID: 12372426
    [TBL] [Abstract][Full Text] [Related]  

  • 22. KSR modulates signal propagation within the MAPK cascade.
    Therrien M; Michaud NR; Rubin GM; Morrison DK
    Genes Dev; 1996 Nov; 10(21):2684-95. PubMed ID: 8946910
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells.
    Zhou L; Tan A; Iasvovskaia S; Li J; Lin A; Hershenson MB
    Am J Respir Cell Mol Biol; 2003 Jun; 28(6):762-9. PubMed ID: 12600818
    [TBL] [Abstract][Full Text] [Related]  

  • 24. NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase.
    Waterfield MR; Zhang M; Norman LP; Sun SC
    Mol Cell; 2003 Mar; 11(3):685-94. PubMed ID: 12667451
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.
    Sugimoto K; Ohata M; Miyoshi J; Ishizaki H; Tsuboi N; Masuda A; Yoshikai Y; Takamoto M; Sugane K; Matsuo S; Shimada Y; Matsuguchi T
    J Clin Invest; 2004 Sep; 114(6):857-66. PubMed ID: 15372110
    [TBL] [Abstract][Full Text] [Related]  

  • 26. TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations.
    Dodhiawala PB; Khurana N; Zhang D; Cheng Y; Li L; Wei Q; Seehra K; Jiang H; Grierson PM; Wang-Gillam A; Lim KH
    J Clin Invest; 2020 Sep; 130(9):4771-4790. PubMed ID: 32573499
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.
    Douziech M; Sahmi M; Laberge G; Therrien M
    Genes Dev; 2006 Apr; 20(7):807-19. PubMed ID: 16600912
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways.
    Gu J; Tamura M; Yamada KM
    J Cell Biol; 1998 Nov; 143(5):1375-83. PubMed ID: 9832564
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Cell adhesion tunes inflammatory TPL2 kinase signal transduction.
    Vougioukalaki M; Georgila K; Athanasiadis EI; Eliopoulos AG
    Cell Mol Life Sci; 2022 Feb; 79(3):156. PubMed ID: 35218437
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
    Das S; Cho J; Lambertz I; Kelliher MA; Eliopoulos AG; Du K; Tsichlis PN
    J Biol Chem; 2005 Jun; 280(25):23748-57. PubMed ID: 15833743
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
    López-Peláez M; Soria-Castro I; Boscá L; Fernández M; Alemany S
    Eur J Immunol; 2011 Jun; 41(6):1733-41. PubMed ID: 21469113
    [TBL] [Abstract][Full Text] [Related]  

  • 32. KSR is a scaffold required for activation of the ERK/MAPK module.
    Roy F; Laberge G; Douziech M; Ferland-McCollough D; Therrien M
    Genes Dev; 2002 Feb; 16(4):427-38. PubMed ID: 11850406
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).
    Koong AC; Chen EY; Mivechi NF; Denko NC; Stambrook P; Giaccia AJ
    Cancer Res; 1994 Oct; 54(20):5273-9. PubMed ID: 7923153
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia.
    Chorzalska A; Ahsan N; Rao RSP; Roder K; Yu X; Morgan J; Tepper A; Hines S; Zhang P; Treaba DO; Zhao TC; Olszewski AJ; Reagan JL; Liang O; Gruppuso PA; Dubielecka PM
    Mol Oncol; 2018 May; 12(5):630-647. PubMed ID: 29485707
    [TBL] [Abstract][Full Text] [Related]  

  • 35. TRAF6 and Src kinase activity regulates Cot activation by IL-1.
    Rodríguez C; Pozo M; Nieto E; Fernández M; Alemany S
    Cell Signal; 2006 Sep; 18(9):1376-85. PubMed ID: 16371247
    [TBL] [Abstract][Full Text] [Related]  

  • 36. KSR, a novel protein kinase required for RAS signal transduction.
    Therrien M; Chang HC; Solomon NM; Karim FD; Wassarman DA; Rubin GM
    Cell; 1995 Dec; 83(6):879-88. PubMed ID: 8521512
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells.
    Chikamatsu S; Furuno T; Kinoshita Y; Inoh Y; Hirashima N; Teshima R; Nakanishi M
    Mol Immunol; 2007 Mar; 44(7):1490-7. PubMed ID: 17049604
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.
    Sanz-Garcia C; Ferrer-Mayorga G; González-Rodríguez Á; Valverde AM; Martín-Duce A; Velasco-Martín JP; Regadera J; Fernández M; Alemany S
    J Biol Chem; 2013 May; 288(21):15342-51. PubMed ID: 23572518
    [TBL] [Abstract][Full Text] [Related]  

  • 39. GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB.
    Bang D; Wilson W; Ryan M; Yeh JJ; Baldwin AS
    Cancer Discov; 2013 Jun; 3(6):690-703. PubMed ID: 23547054
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
    Beinke S; Robinson MJ; Hugunin M; Ley SC
    Mol Cell Biol; 2004 Nov; 24(21):9658-67. PubMed ID: 15485931
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.