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3. Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. de Costa BR; Rice KC; Bowen WD; Thurkauf A; Rothman RB; Band L; Jacobson AE; Radesca L; Contreras PC; Gray NM J Med Chem; 1990 Nov; 33(11):3100-10. PubMed ID: 2172538 [TBL] [Abstract][Full Text] [Related]
4. Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds. Hudkins RL; Mailman RB; DeHaven-Hudkins DL J Med Chem; 1994 Jun; 37(13):1964-70. PubMed ID: 8027978 [TBL] [Abstract][Full Text] [Related]
5. N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors. Wikström H; Andersson B; Elebring T; Svensson K; Carlsson A; Largent B J Med Chem; 1987 Dec; 30(12):2169-74. PubMed ID: 2824773 [TBL] [Abstract][Full Text] [Related]
6. Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. de Costa BR; Bowen WD; Hellewell SB; George C; Rothman RB; Reid AA; Walker JM; Jacobson AE; Rice KC J Med Chem; 1989 Aug; 32(8):1996-2002. PubMed ID: 2547074 [TBL] [Abstract][Full Text] [Related]
7. Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors. de Costa BR; Bowen WD; Hellewell SB; Walker JM; Thurkauf A; Jacobson AE; Rice KC FEBS Lett; 1989 Jul; 251(1-2):53-8. PubMed ID: 2568952 [TBL] [Abstract][Full Text] [Related]
8. Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site. Mewshaw RE; Sherrill RG; Mathew RM; Kaiser C; Bailey MA; Karbon EW J Med Chem; 1993 Feb; 36(3):343-52. PubMed ID: 8426363 [TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. de Costa BR; Dominguez C; He XS; Williams W; Radesca L; Bowen W J Med Chem; 1992 Nov; 35(23):4334-43. PubMed ID: 1447735 [TBL] [Abstract][Full Text] [Related]
10. Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands. Glennon RA; Yousif MY; Ismaiel AM; el-Ashmawy MB; Herndon JL; Fischer JB; Server AC; Howie KJ J Med Chem; 1991 Dec; 34(12):3360-5. PubMed ID: 1662725 [TBL] [Abstract][Full Text] [Related]
11. Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines. Van de Waterbeemd H; el Tayar N; Testa B; Wikström H; Largent B J Med Chem; 1987 Dec; 30(12):2175-81. PubMed ID: 2824774 [TBL] [Abstract][Full Text] [Related]
13. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Hellewell SB; Bowen WD Brain Res; 1990 Sep; 527(2):244-53. PubMed ID: 2174717 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. Scherz MW; Fialeix M; Fischer JB; Reddy NL; Server AC; Sonders MS; Tester BC; Weber E; Wong ST; Keana JF J Med Chem; 1990 Sep; 33(9):2421-9. PubMed ID: 1975275 [TBL] [Abstract][Full Text] [Related]
15. RLH-033, a novel, potent and selective ligand for the sigma 1 recognition site. Hudkins RL; Mailman RB; DeHaven-Hudkins DL Eur J Pharmacol; 1994 Dec; 271(1):235-6. PubMed ID: 7698207 [TBL] [Abstract][Full Text] [Related]
16. Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane. Wallace DR; Booze RM J Neurochem; 1995 Feb; 64(2):700-10. PubMed ID: 7830063 [TBL] [Abstract][Full Text] [Related]
17. Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Tam SW; Cook L Proc Natl Acad Sci U S A; 1984 Sep; 81(17):5618-21. PubMed ID: 6147851 [TBL] [Abstract][Full Text] [Related]
19. 1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs. Weber E; Sonders M; Quarum M; McLean S; Pou S; Keana JF Proc Natl Acad Sci U S A; 1986 Nov; 83(22):8784-8. PubMed ID: 2877462 [TBL] [Abstract][Full Text] [Related]