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3. Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine. Ando A; Momomura K; Tobe K; Yamamoto-Honda R; Sakura H; Tamori Y; Kaburagi Y; Koshio O; Akanuma Y; Yazaki Y J Biol Chem; 1992 Jun; 267(18):12788-96. PubMed ID: 1618780 [TBL] [Abstract][Full Text] [Related]
4. The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases. Wilden PA; Kahn CR Mol Endocrinol; 1994 May; 8(5):558-67. PubMed ID: 8058065 [TBL] [Abstract][Full Text] [Related]
5. Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action. Krook A; Moller DE; Dib K; O'Rahilly S J Biol Chem; 1996 Mar; 271(12):7134-40. PubMed ID: 8636149 [TBL] [Abstract][Full Text] [Related]
6. N-linked oligosaccharide chains of the insulin receptor beta subunit are essential for transmembrane signaling. Leconte I; Auzan C; Debant A; Rossi B; Clauser E J Biol Chem; 1992 Aug; 267(24):17415-23. PubMed ID: 1324936 [TBL] [Abstract][Full Text] [Related]
7. Differential role of insulin receptor autophosphorylation sites 1162 and 1163 in the long-term insulin stimulation of glucose transport, glycogenesis, and protein synthesis. Desbois C; Capeau J; Hainault I; Wicek D; Reynet C; Veissière D; Caron M; Picard J; Guerre-Millo M; Cherqui G J Biol Chem; 1992 Jul; 267(19):13488-97. PubMed ID: 1618850 [TBL] [Abstract][Full Text] [Related]
8. Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin. Yamamoto-Honda R; Kadowaki T; Momomura K; Tobe K; Tamori Y; Shibasaki Y; Mori Y; Kaburagi Y; Koshio O; Akanuma Y J Biol Chem; 1993 Aug; 268(22):16859-65. PubMed ID: 8344965 [TBL] [Abstract][Full Text] [Related]
9. Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact. Van der Zon GC; Ouwens DM; Dorrestijn J; Maassen JA Biochemistry; 1996 Aug; 35(32):10377-82. PubMed ID: 8756693 [TBL] [Abstract][Full Text] [Related]
10. Two sequences flanking the major autophosphorylation site of the insulin receptor are essential for tyrosine kinase activation. Leconte I; Clauser E Biochem J; 1995 Mar; 306 ( Pt 2)(Pt 2):465-72. PubMed ID: 7887900 [TBL] [Abstract][Full Text] [Related]
11. The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus. Myers MG; Backer JM; Siddle K; White MF J Biol Chem; 1991 Jun; 266(16):10616-23. PubMed ID: 1645354 [TBL] [Abstract][Full Text] [Related]
12. Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. Chou CK; Dull TJ; Russell DS; Gherzi R; Lebwohl D; Ullrich A; Rosen OM J Biol Chem; 1987 Feb; 262(4):1842-7. PubMed ID: 3100537 [TBL] [Abstract][Full Text] [Related]
13. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. Yamada K; Goncalves E; Kahn CR; Shoelson SE J Biol Chem; 1992 Jun; 267(18):12452-61. PubMed ID: 1352286 [TBL] [Abstract][Full Text] [Related]
14. Insulin signal transduction by a mutant human insulin receptor lacking the NPEY sequence. Evidence for an alternate mitogenic signaling pathway that is independent of Shc phosphorylation. Berhanu P; Anderson C; Hickman M; Ciaraldi TP J Biol Chem; 1997 Sep; 272(36):22884-90. PubMed ID: 9278451 [TBL] [Abstract][Full Text] [Related]
15. Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants. Sung CK; Han XL; Brunetti A; Maddux B; Yamamoto-Honda R; Goldfine ID Biochemistry; 1992 Jan; 31(1):168-74. PubMed ID: 1731870 [TBL] [Abstract][Full Text] [Related]
16. Cysteine-524 is not the only residue involved in the formation of disulphide-bonded dimers of the insulin receptor. Macaulay SL; Polites M; Hewish DR; Ward CW Biochem J; 1994 Oct; 303 ( Pt 2)(Pt 2):575-81. PubMed ID: 7980420 [TBL] [Abstract][Full Text] [Related]
17. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. Kaburagi Y; Momomura K; Yamamoto-Honda R; Tobe K; Tamori Y; Sakura H; Akanuma Y; Yazaki Y; Kadowaki T J Biol Chem; 1993 Aug; 268(22):16610-22. PubMed ID: 8393870 [TBL] [Abstract][Full Text] [Related]
18. Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. Takata Y; Webster NJ; Olefsky JM J Biol Chem; 1992 May; 267(13):9065-70. PubMed ID: 1577744 [TBL] [Abstract][Full Text] [Related]
19. Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant. Moller DE; Benecke H; Flier JS J Biol Chem; 1991 Jun; 266(17):10995-1001. PubMed ID: 1645719 [TBL] [Abstract][Full Text] [Related]
20. Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. Cama A; Quon MJ; de la Luz Sierra M; Taylor SI J Biol Chem; 1992 Apr; 267(12):8383-9. PubMed ID: 1314826 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]