These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 1321908)

  • 1. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
    Crawley GC; Dowell RI; Edwards PN; Foster SJ; McMillan RM; Walker ER; Waterson D; Bird TG; Bruneau P; Giroaeau JM
    J Med Chem; 1992 Jul; 35(14):2600-9. PubMed ID: 1321908
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    McMillan RM; Spruce KE; Crawley GC; Walker ER; Foster SJ
    Br J Pharmacol; 1992 Dec; 107(4):1042-7. PubMed ID: 1334748
    [TBL] [Abstract][Full Text] [Related]  

  • 3. (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
    Bird ; Bruneau P; Crawley GC; Edwards MP; Foster SJ; Girodeau JM; Kingston JF; McMillan RM
    J Med Chem; 1991 Jul; 34(7):2176-86. PubMed ID: 1648621
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.
    Crawley GC; Bird TG; Bruneau P; Dowell RI; Edwards PN; Foster SJ; Girodeau JM; McMillan RM; Walker ER; Waterson D
    J Lipid Mediat; 1993; 6(1-3):249-57. PubMed ID: 8395247
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Methoxyalkyl thiazoles: a novel series of potent, orally active and enantioselective inhibitors of 5-lipoxygenase.
    McMillan RM; Bird TG; Crawley GC; Edwards MP; Girodeau JM; Kingston JF; Foster SJ
    Agents Actions; 1991 Sep; 34(1-2):110-2. PubMed ID: 1793013
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.
    Lambert-van der Brempt C; Bruneau P; Lamorlette MA; Foster SJ
    J Med Chem; 1994 Jan; 37(1):113-24. PubMed ID: 8289184
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
    Ducharme Y; Brideau C; Dubé D; Chan CC; Falgueyret JP; Gillard JW; Guay J; Hutchinson JH; McFarlane CS; Riendeau D
    J Med Chem; 1994 Feb; 37(4):512-8. PubMed ID: 8120869
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
    Malamas MS; Carlson RP; Grimes D; Howell R; Glaser K; Gunawan I; Nelson JA; Kanzelberger M; Shah U; Hartman DA
    J Med Chem; 1996 Jan; 39(1):237-45. PubMed ID: 8568813
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
    Hutchinson JH; Riendeau D; Brideau C; Chan C; Falgueyret JP; Guay J; Jones TR; Lépine C; Macdonald D; McFarlane CS
    J Med Chem; 1994 Apr; 37(8):1153-64. PubMed ID: 8164257
    [TBL] [Abstract][Full Text] [Related]  

  • 10. WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
    Grimes D; Sturm RJ; Marinari LR; Carlson RP; Berkenkopf JW; Musser JH; Kreft AF; Weichman BM
    Eur J Pharmacol; 1993 May; 236(2):217-28. PubMed ID: 8391458
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 2-substituted indazolinones: orally active and selective 5-lipoxygenase inhibitors with anti-inflammatory activity.
    Foster SJ; Bruneau P; Walker ER; McMillan RM
    Br J Pharmacol; 1990 Jan; 99(1):113-8. PubMed ID: 2110012
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.
    Kusner EJ; Buckner CK; Dea DM; DeHaas CJ; Marks RL; Krell RD
    Eur J Pharmacol; 1994 May; 257(3):285-92. PubMed ID: 7522174
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse.
    Cunningham FM; Andrews M; Landoni MF; Lees P
    J Vet Pharmacol Ther; 1997 Aug; 20(4):296-307. PubMed ID: 9280370
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.
    Hutchinson JH; Riendeau D; Brideau C; Chan C; Delorme D; Denis D; Falgueyret JP; Fortin R; Guay J; Hamel P
    J Med Chem; 1993 Sep; 36(19):2771-87. PubMed ID: 8410991
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chiral dioxolane inhibitors of leukotriene biosynthesis: structure-activity relationships and syntheses using asymmetric dihydroxylation.
    Crawley GC; Briggs MT
    J Med Chem; 1995 Sep; 38(20):3951-6. PubMed ID: 7562928
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1.
    Foster SJ; McCormick ME; Howarth A; Aked D
    Biochem Pharmacol; 1986 May; 35(10):1709-17. PubMed ID: 3011012
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models.
    Carty TJ; Sweeney FJ; Griffiths RJ; Eskra JD; Ernest MJ; Pillar JS; Cheng JD; Loose LD; Joseph PA; Pazoles PP; Moore PF; Nagahisa A; Murase S; Kadin SB
    Inflamm Res; 1997 May; 46(5):168-79. PubMed ID: 9197987
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis.
    Fruchtmann R; Mohrs KH; Hatzelmann A; Raddatz S; Fugmann B; Junge B; Horstmann H; Müller-Peddinghaus R
    Agents Actions; 1993 Mar; 38(3-4):188-95. PubMed ID: 8213345
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.
    Kimble E; Kowalski T; White D; Raychauduri A; Pastor G; Chertock H; Lee W; Neale R; Hamdan A; Wasley J
    Agents Actions; 1991 Sep; 34(1-2):125-8. PubMed ID: 1665286
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
    Crawley GC; Briggs MT; Dowell RI; Edwards PN; Hamilton PM; Kingston JF; Oldham K; Waterson D; Whalley DP
    J Med Chem; 1993 Jan; 36(2):295-6. PubMed ID: 8380872
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 7.