BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 1333829)

  • 1. Synthesis and biological activity of 5-(2,2-difluorocyclopropyl)-2'-deoxyuridine deoxyuridine diastereomers.
    Tandon M; Singh S; Xu L; Kumar P; Wiebe LI; Knaus EE; Gati WP; Tempest ML
    Drug Des Discov; 1992; 9(1):79-91. PubMed ID: 1333829
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of the diastereomers of 5-(2,2-dichlorocyclopropyl)- and 5-(2-chlorocyclopropyl)-2'-deoxyuridine, and the antiviral and cytotoxic activity of these and bromo analogues.
    Tandon M; Singh S; Wiebe LI; Knaus EE; Gati WP; Tempest ML
    Drug Des Deliv; 1991 Jul; 7(4):295-307. PubMed ID: 1657019
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
    Balzarini J; De Clercq E; Baumgartner H; Bodenteich M; Griengl H
    Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Balzarini J; Baumgartner H; Bodenteich M; De Clercq E; Griengl H
    J Med Chem; 1989 Aug; 32(8):1861-5. PubMed ID: 2547072
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
    Herdewijn P; De Clercq E; Balzarini J; Vanderhaeghe H
    J Med Chem; 1985 May; 28(5):550-5. PubMed ID: 2985782
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses.
    Meerbach A; Meier C; Sauerbrei A; Meckel HM; Wutzler P
    Int J Antimicrob Agents; 2006 May; 27(5):423-30. PubMed ID: 16621459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
    Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Shimizu K; Seno T
    Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
    Grignet-Debrus C; Cool V; Baudson N; Degrève B; Balzarini J; De Leval L; Debrus S; Velu T; Calberg-Bacq CM
    Cancer Gene Ther; 2000 Feb; 7(2):215-23. PubMed ID: 10770629
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
    Balzarini J; De Clercq E
    Methods Find Exp Clin Pharmacol; 1989 Jun; 11(6):379-89. PubMed ID: 2545982
    [No Abstract]   [Full Text] [Related]  

  • 10. Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
    Griengl H; Hayden W; Penn G; De Clercq E; Rosenwirth B
    J Med Chem; 1988 Sep; 31(9):1831-9. PubMed ID: 2842506
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
    Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Seno T
    Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The synthesis and properties of some 5-substituted uracil derivatives.
    Walker RT; Jones AS; Rahim SG; Serafinowski P; De Clercq E
    Nucleic Acids Symp Ser; 1981; (9):21-4. PubMed ID: 7301597
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
    Cristofoli WA; Wiebe LI; De Clercq E; Andrei G; Snoeck R; Balzarini J; Knaus EE
    J Med Chem; 2007 Jun; 50(12):2851-7. PubMed ID: 17518459
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differential inhibition of herpes simplex viruses, type 1 (HSV-1) an type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2'-deoxyuridines.
    de Clercq E; Verhelst G; Descamps J; Bergstrom DE
    Acta Microbiol Acad Sci Hung; 1981; 28(3):307-12. PubMed ID: 6272553
    [No Abstract]   [Full Text] [Related]  

  • 15. Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers.
    Cheraghali AM; Kumar R; Wang L; Knaus EE; Wiebe LI
    Biochem Pharmacol; 1994 Apr; 47(9):1615-25. PubMed ID: 8185676
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, antiviral and cytotoxic activity of 2'-deoxyuridines, 2'-fluoro-2'-deoxyuridines and 2'-arabinouridines containing 5-(1-hydroxy-2-halo-2-ethoxycarbonylethyl)-, 5-(1-hydroxy-2-iodo-2- carboxyethyl)- and 5-[1-hydroxy (or methoxy)-2-iodoethyl] substituents.
    Kumar R; Wiebe LI; Knaus EE; Allen TM; Tempest ML
    Drug Des Discov; 1992 Feb; 8(3):179-89. PubMed ID: 1326340
    [TBL] [Abstract][Full Text] [Related]  

  • 17. (E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
    Hamel W; Zirkel D; Mehdorn HM; Westphal M; Israel MA
    Cancer Gene Ther; 2001 May; 8(5):388-96. PubMed ID: 11477459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
    Griengl H; Wanek E; Schwarz W; Streicher W; Rosenwirth B; De Clercq E
    J Med Chem; 1987 Jul; 30(7):1199-204. PubMed ID: 3037079
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
    Degrève B; De Clercq E; Balzarini J
    Gene Ther; 2000 Sep; 7(18):1543-52. PubMed ID: 11021592
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biodistribution of [4-14C]-5-bromo-6-methoxy-5,6-dihydro-prodrug derivatives of 5-ethyl-2'-deoxyuridine.
    Cheraghali AM; Morin KW; Kumar R; Knaus EE; Wiebe LI
    Drug Des Discov; 1994 Jul; 12(1):53-61. PubMed ID: 7578807
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.