BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

346 related articles for article (PubMed ID: 1374417)

  • 1. Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum.
    Roitelman J; Olender EH; Bar-Nun S; Dunn WA; Simoni RD
    J Cell Biol; 1992 Jun; 117(5):959-73. PubMed ID: 1374417
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular dissection of the role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Kumagai H; Chun KT; Simoni RD
    J Biol Chem; 1995 Aug; 270(32):19107-13. PubMed ID: 7642576
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain.
    Xu L; Simoni RD
    Arch Biochem Biophys; 2003 Jun; 414(2):232-43. PubMed ID: 12781775
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum.
    Chun KT; Bar-Nun S; Simoni RD
    J Biol Chem; 1990 Dec; 265(35):22004-10. PubMed ID: 2254343
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutation in the lumenal part of the membrane domain of HMG-CoA reductase alters its regulated degradation.
    Sekler MS; Simoni RD
    Biochem Biophys Res Commun; 1995 Jan; 206(1):186-93. PubMed ID: 7818519
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase.
    Roitelman J; Simoni RD
    J Biol Chem; 1992 Dec; 267(35):25264-73. PubMed ID: 1460026
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The regulated degradation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase reporter construct occurs in the endoplasmic reticulum.
    Lecureux LW; Wattenberg BW
    J Cell Sci; 1994 Sep; 107 ( Pt 9)():2635-42. PubMed ID: 7844177
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase.
    Roitelman J; Bar-Nun S; Inoue S; Simoni RD
    J Biol Chem; 1991 Aug; 266(24):16085-91. PubMed ID: 1908464
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation.
    Doolman R; Leichner GS; Avner R; Roitelman J
    J Biol Chem; 2004 Sep; 279(37):38184-93. PubMed ID: 15247208
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors.
    Inoue S; Bar-Nun S; Roitelman J; Simoni RD
    J Biol Chem; 1991 Jul; 266(20):13311-7. PubMed ID: 1906466
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase.
    Olender EH; Simon RD
    J Biol Chem; 1992 Feb; 267(6):4223-35. PubMed ID: 1740462
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Non-sterol compounds that regulate cholesterogenesis. Analogues of farnesyl pyrophosphate reduce 3-hydroxy-3-methylglutaryl-coenzyme A reductase levels.
    Bradfute DL; Simoni RD
    J Biol Chem; 1994 Mar; 269(9):6645-50. PubMed ID: 8120018
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.
    Moriyama T; Wada M; Urade R; Kito M; Katunuma N; Ogawa T; Simoni RD
    Arch Biochem Biophys; 2001 Feb; 386(2):205-12. PubMed ID: 11368343
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Chun KT; Simoni RD
    J Biol Chem; 1992 Feb; 267(6):4236-46. PubMed ID: 1740463
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase.
    Cheng HH; Xu L; Kumagai H; Simoni RD
    J Biol Chem; 1999 Jun; 274(24):17171-8. PubMed ID: 10358074
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase.
    Skalnik DG; Narita H; Kent C; Simoni RD
    J Biol Chem; 1988 May; 263(14):6836-41. PubMed ID: 2834394
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells.
    Meigs TE; Simoni RD
    J Biol Chem; 1992 Jul; 267(19):13547-52. PubMed ID: 1618856
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
    Hampton RY; Gardner RG; Rine J
    Mol Biol Cell; 1996 Dec; 7(12):2029-44. PubMed ID: 8970163
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.
    McGee TP; Cheng HH; Kumagai H; Omura S; Simoni RD
    J Biol Chem; 1996 Oct; 271(41):25630-8. PubMed ID: 8810339
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease.
    Moriyama T; Sather SK; McGee TP; Simoni RD
    J Biol Chem; 1998 Aug; 273(34):22037-43. PubMed ID: 9705346
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.