BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 1394842)

  • 1. Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions.
    Shou M; Harvey RG; Penning TM
    Carcinogenesis; 1992 Sep; 13(9):1575-82. PubMed ID: 1394842
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes.
    Flowers-Geary L; Harvey RG; Penning TM
    Carcinogenesis; 1995 Nov; 16(11):2707-15. PubMed ID: 7586190
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
    Flowers L; Bleczinski WF; Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1996 Oct; 35(42):13664-72. PubMed ID: 8885846
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
    Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1998 May; 37(19):6781-90. PubMed ID: 9578563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism of 7,8-dihydrobenzo(a)pyrene by rat liver microsomal enzymes and mutagenicity of metabolites.
    Chiu PL; Yang SK
    Cancer Res; 1986 Oct; 46(10):5084-94. PubMed ID: 3756866
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death.
    Tsuruda L; Hou Yt ; Penning TM
    Chem Res Toxicol; 2001 Jul; 14(7):856-62. PubMed ID: 11453732
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
    Shou M; Harvey RG; Penning TM
    Carcinogenesis; 1993 Mar; 14(3):475-82. PubMed ID: 8384091
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
    Shimada T; Martin MV; Pruess-Schwartz D; Marnett LJ; Guengerich FP
    Cancer Res; 1989 Nov; 49(22):6304-12. PubMed ID: 2509067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase.
    Flowers-Geary L; Harvey RG; Penning TM
    Chem Res Toxicol; 1992; 5(4):576-83. PubMed ID: 1391625
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
    Penning TM
    Chem Biol Interact; 1993 Oct; 89(1):1-34. PubMed ID: 8221964
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prostaglandin synthetase and cytochrome P-450-dependent metabolism of (+/-)benzo(a)pyrene 7,8-dihydrodiol by enriched populations of rat Clara cells and alveolar type II cells.
    Sivarajah K; Jones KG; Fouts JR; Devereux T; Shirley JE; Eling TE
    Cancer Res; 1983 Jun; 43(6):2632-6. PubMed ID: 6303564
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic activation of racemic and enantiomeric trans-8, 9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (dibenzo[def,p]chrysene) to dibenzo[a,l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a,l]pyrene-DNA adducts.
    Nesnow S; Davis C; Padgett W; George M; Lambert G; Meyers F; Allison J; Adams L; King LC
    Chem Res Toxicol; 1998 Dec; 11(12):1596-607. PubMed ID: 9860506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
    Burczynski ME; Lin HK; Penning TM
    Cancer Res; 1999 Feb; 59(3):607-14. PubMed ID: 9973208
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Radiochemical detection of dihydrodiol dehydrogenase: distribution of the enzyme in male Sprague-Dawley rat tissues and its sensitivity to inhibition by indomethacin and 6-medroxyprogesterone acetate.
    Ivins JK; Penning TM
    Cancer Res; 1987 Feb; 47(3):680-4. PubMed ID: 3542192
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp.
    Zaleski J; Steward AR; Sikka HC
    Carcinogenesis; 1991 Feb; 12(2):167-74. PubMed ID: 1995182
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.
    Thakker DR; Levin W; Buening M; Yagi H; Lehr RE; Wood AW; Conney AH; Jerina DM
    Cancer Res; 1981 Apr; 41(4):1389-96. PubMed ID: 7194138
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.
    Thakker DR; Yagi H; Lu AY; Levin W; Conney AH
    Proc Natl Acad Sci U S A; 1976 Oct; 73(10):3381-5. PubMed ID: 1068451
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biotransformation of trans-4,5-dihydroxy-4,5-dihydrobenzo[a]pyrene to benzo[a]pyrene bis-diols and DNA adducts by induced rat liver microsomes.
    Padgett WT; Davis C; Lambert G; Nelson GB; Ross JA; Yacopucci M; Nesnow S
    Chem Res Toxicol; 2000 Nov; 13(11):1125-34. PubMed ID: 11087434
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons.
    Smithgall TE; Harvey RG; Penning TM
    J Biol Chem; 1986 May; 261(14):6184-91. PubMed ID: 3457793
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes of brown bullheads.
    Steward AR; Zaleski J; Sikka HC
    Chem Biol Interact; 1990; 74(1-2):119-38. PubMed ID: 2322950
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.