BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 1441599)

  • 1. Polymorphism in stereoselective hydroxylations of mephenytoin and hexobarbital by Japanese liver samples in relation to cytochrome P-450 human-2 (IIC9).
    Kato R; Yamazoe Y; Yasumori T
    Xenobiotica; 1992; 22(9-10):1083-92. PubMed ID: 1441599
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.
    Yasumori T; Murayama N; Yamazoe Y; Kato R
    Clin Pharmacol Ther; 1990 Mar; 47(3):313-22. PubMed ID: 2311333
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens.
    Kato R; Yamazoe Y; Yasumori T
    Princess Takamatsu Symp; 1990; 21():45-53. PubMed ID: 2134689
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytochrome P-450 human-2 (P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts.
    Yasumori T; Yamazoe Y; Kato R
    J Biochem; 1991 May; 109(5):711-7. PubMed ID: 1917894
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
    Brian WR; Srivastava PK; Umbenhauer DR; Lloyd RS; Guengerich FP
    Biochemistry; 1989 Jun; 28(12):4993-9. PubMed ID: 2669966
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
    Knodell RG; Dubey RK; Wilkinson GR; Guengerich FP
    J Pharmacol Exp Ther; 1988 Jun; 245(3):845-9. PubMed ID: 3385644
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
    Meyer UA; Gut J; Kronbach T; Skoda C; Meier UT; Catin T; Dayer P
    Xenobiotica; 1986 May; 16(5):449-64. PubMed ID: 2874666
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A).
    Yasumori T; Chen L; Nagata K; Yamazoe Y; Kato R
    J Pharmacol Exp Ther; 1993 Jan; 264(1):89-94. PubMed ID: 8423554
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
    Lasker JM; Wester MR; Aramsombatdee E; Raucy JL
    Arch Biochem Biophys; 1998 May; 353(1):16-28. PubMed ID: 9578596
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects.
    Adedoyin A; Prakash C; O'Shea D; Blair IA; Wilkinson GR
    Pharmacogenetics; 1994 Feb; 4(1):27-38. PubMed ID: 8004130
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.
    Shimada T; Misono KS; Guengerich FP
    J Biol Chem; 1986 Jan; 261(2):909-21. PubMed ID: 3079764
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
    Srivastava PK; Yun CH; Beaune PH; Ged C; Guengerich FP
    Mol Pharmacol; 1991 Jul; 40(1):69-79. PubMed ID: 1857342
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency.
    Meier UT; Meyer UA
    Biochemistry; 1987 Dec; 26(25):8466-74. PubMed ID: 3442670
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes.
    Kobayashi K; Kogo M; Tani M; Shimada N; Ishizaki T; Numazawa S; Yoshida T; Yamamoto T; Kuroiwa Y; Chiba K
    Drug Metab Dispos; 2001 Jan; 29(1):36-40. PubMed ID: 11124227
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A methodological investigation on the estimation of the S-mephenytoin hydroxylation phenotype using the urinary S/R ratio.
    Tybring G; Bertilsson L
    Pharmacogenetics; 1992 Oct; 2(5):241-3. PubMed ID: 1306124
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.
    Ieiri I; Mamiya K; Urae A; Wada Y; Kimura M; Irie S; Amamoto T; Kubota T; Yoshioka S; Nakamura K; Nakano S; Tashiro N; Higuchi S
    Br J Clin Pharmacol; 1997 Apr; 43(4):441-5. PubMed ID: 9146858
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.
    Goldstein JA; Faletto MB; Romkes-Sparks M; Sullivan T; Kitareewan S; Raucy JL; Lasker JM; Ghanayem BI
    Biochemistry; 1994 Feb; 33(7):1743-52. PubMed ID: 8110777
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Participation of a rat liver cytochrome P-450 induced by pregnenolone 16 alpha-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin.
    Shimada T; Guengerich FP
    Mol Pharmacol; 1985 Aug; 28(2):215-9. PubMed ID: 4022003
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo.
    Meier UT; Dayer P; Malè PJ; Kronbach T; Meyer UA
    Clin Pharmacol Ther; 1985 Nov; 38(5):488-94. PubMed ID: 4053486
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.
    Relling MV; Aoyama T; Gonzalez FJ; Meyer UA
    J Pharmacol Exp Ther; 1990 Jan; 252(1):442-7. PubMed ID: 2299601
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.