BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 14500394)

  • 1. The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.
    Ikeda T; Sporn M; Honda T; Gribble GW; Kufe D
    Cancer Res; 2003 Sep; 63(17):5551-8. PubMed ID: 14500394
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.
    Ito Y; Pandey P; Place A; Sporn MB; Gribble GW; Honda T; Kharbanda S; Kufe D
    Cell Growth Differ; 2000 May; 11(5):261-7. PubMed ID: 10845427
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.
    Ikeda T; Nakata Y; Kimura F; Sato K; Anderson K; Motoyoshi K; Sporn M; Kufe D
    Mol Cancer Ther; 2004 Jan; 3(1):39-45. PubMed ID: 14749474
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia.
    Konopleva M; Tsao T; Estrov Z; Lee RM; Wang RY; Jackson CE; McQueen T; Monaco G; Munsell M; Belmont J; Kantarjian H; Sporn MB; Andreeff M
    Cancer Res; 2004 Nov; 64(21):7927-35. PubMed ID: 15520199
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
    Hyer ML; Shi R; Krajewska M; Meyer C; Lebedeva IV; Fisher PB; Reed JC
    Cancer Res; 2008 Apr; 68(8):2927-33. PubMed ID: 18413762
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis.
    Samudio I; Konopleva M; Pelicano H; Huang P; Frolova O; Bornmann W; Ying Y; Evans R; Contractor R; Andreeff M
    Mol Pharmacol; 2006 Apr; 69(4):1182-93. PubMed ID: 16410408
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.
    Chen C; Shen G; Hebbar V; Hu R; Owuor ED; Kong AN
    Carcinogenesis; 2003 Aug; 24(8):1369-78. PubMed ID: 12819184
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
    Yue P; Zhou Z; Khuri FR; Sun SY
    Cancer Biol Ther; 2006 May; 5(5):492-7. PubMed ID: 16582599
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
    Wu SJ; Ng LT; Lin CC
    Eur J Pharmacol; 2005 Aug; 518(2-3):96-106. PubMed ID: 16054126
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
    Stadheim TA; Suh N; Ganju N; Sporn MB; Eastman A
    J Biol Chem; 2002 May; 277(19):16448-55. PubMed ID: 11880365
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria.
    Watabe M; Machida K; Osada H
    Cancer Res; 2000 Sep; 60(18):5214-22. PubMed ID: 11016650
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway.
    Decker RH; Dai Y; Grant S
    Cell Death Differ; 2001 Jul; 8(7):715-24. PubMed ID: 11464216
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism.
    Ito Y; Pandey P; Sporn MB; Datta R; Kharbanda S; Kufe D
    Mol Pharmacol; 2001 May; 59(5):1094-9. PubMed ID: 11306692
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade.
    Ko CH; Shen SC; Hsu CS; Chen YC
    Biochem Pharmacol; 2005 Mar; 69(6):913-27. PubMed ID: 15748703
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels.
    Riccioni R; Senese M; Diverio D; Riti V; Mariani G; Boe A; LoCoco F; Foà R; Peschle C; Sporn M; Testa U
    Leuk Res; 2008 Aug; 32(8):1244-58. PubMed ID: 18304628
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.
    Petronelli A; Saulle E; Pasquini L; Petrucci E; Mariani G; Biffoni M; Ferretti G; Scambia G; Benedetti-Panici P; Greggi S; Cognetti F; Russo MA; Sporn M; Testa U
    Cancer Lett; 2009 Sep; 282(2):214-28. PubMed ID: 19364626
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis.
    Ramos AM; Fernandez C; Amrán D; Esteban D; de Blas E; Palacios MA; Aller P
    J Cell Physiol; 2006 Dec; 209(3):1006-15. PubMed ID: 16972261
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.
    Lahusen T; De Siervi A; Kunick C; Senderowicz AM
    Mol Carcinog; 2003 Apr; 36(4):183-94. PubMed ID: 12669310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation.
    Shim HY; Park JH; Paik HD; Nah SY; Kim DS; Han YS
    Mol Cells; 2007 Aug; 24(1):95-104. PubMed ID: 17846503
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells.
    Tong X; Lin S; Fujii M; Hou DX
    Biochem Biophys Res Commun; 2004 Aug; 321(3):539-46. PubMed ID: 15358141
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.