BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

486 related articles for article (PubMed ID: 14500738)

  • 1. Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
    Malherbe P; Kratochwil N; Zenner MT; Piussi J; Diener C; Kratzeisen C; Fischer C; Porter RH
    Mol Pharmacol; 2003 Oct; 64(4):823-32. PubMed ID: 14500738
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
    Malherbe P; Kratochwil N; Mühlemann A; Zenner MT; Fischer C; Stahl M; Gerber PR; Jaeschke G; Porter RH
    J Neurochem; 2006 Jul; 98(2):601-15. PubMed ID: 16805850
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor.
    Malherbe P; Kratochwil N; Knoflach F; Zenner MT; Kew JN; Kratzeisen C; Maerki HP; Adam G; Mutel V
    J Biol Chem; 2003 Mar; 278(10):8340-7. PubMed ID: 12509432
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
    Gasparini F; Lingenhöhl K; Stoehr N; Flor PJ; Heinrich M; Vranesic I; Biollaz M; Allgeier H; Heckendorn R; Urwyler S; Varney MA; Johnson EC; Hess SD; Rao SP; Sacaan AI; Santori EM; Veliçelebi G; Kuhn R
    Neuropharmacology; 1999 Oct; 38(10):1493-503. PubMed ID: 10530811
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
    Pagano A; Ruegg D; Litschig S; Stoehr N; Stierlin C; Heinrich M; Floersheim P; Prezèau L; Carroll F; Pin JP; Cambria A; Vranesic I; Flor PJ; Gasparini F; Kuhn R
    J Biol Chem; 2000 Oct; 275(43):33750-8. PubMed ID: 10934211
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.
    Rodriguez AL; Nong Y; Sekaran NK; Alagille D; Tamagnan GD; Conn PJ
    Mol Pharmacol; 2005 Dec; 68(6):1793-802. PubMed ID: 16155210
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
    Anderson JJ; Rao SP; Rowe B; Giracello DR; Holtz G; Chapman DF; Tehrani L; Bradbury MJ; Cosford ND; Varney MA
    J Pharmacol Exp Ther; 2002 Dec; 303(3):1044-51. PubMed ID: 12438526
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
    Storto M; de Grazia U; Knöpfel T; Canonico PL; Copani A; Richelmi P; Nicoletti F; Vairetti M
    Hepatology; 2000 Mar; 31(3):649-55. PubMed ID: 10706555
    [TBL] [Abstract][Full Text] [Related]  

  • 9. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
    Chen Y; Goudet C; Pin JP; Conn PJ
    Mol Pharmacol; 2008 Mar; 73(3):909-18. PubMed ID: 18056795
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.
    Butkiewicz M; Rodriguez AL; Rainey SE; Wieting J; Luscombe VB; Stauffer SR; Lindsley CW; Conn PJ; Meiler J
    ACS Chem Neurosci; 2019 Aug; 10(8):3427-3436. PubMed ID: 31132237
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    Lea PM; Movsesyan VA; Faden AI
    Br J Pharmacol; 2005 Jun; 145(4):527-34. PubMed ID: 15821750
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.
    Tharmalingam S; Burns AR; Roy PJ; Hampson DR
    Neuropharmacology; 2012 Sep; 63(4):667-74. PubMed ID: 22652059
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
    Porter RH; Jaeschke G; Spooren W; Ballard TM; Büttelmann B; Kolczewski S; Peters JU; Prinssen E; Wichmann J; Vieira E; Mühlemann A; Gatti S; Mutel V; Malherbe P
    J Pharmacol Exp Ther; 2005 Nov; 315(2):711-21. PubMed ID: 16040814
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.
    Cappuccio I; Spinsanti P; Porcellini A; Desiderati F; De Vita T; Storto M; Capobianco L; Battaglia G; Nicoletti F; Melchiorri D
    Neuropharmacology; 2005; 49 Suppl 1():196-205. PubMed ID: 16023153
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes.
    Frati C; Marchese C; Fisichella G; Copani A; Nasca MR; Storto M; Nicoletti F
    J Cell Physiol; 2000 Jun; 183(3):364-72. PubMed ID: 10797311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.
    Lundström L; Bissantz C; Beck J; Wettstein JG; Woltering TJ; Wichmann J; Gatti S
    Br J Pharmacol; 2011 Sep; 164(2b):521-37. PubMed ID: 21470207
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
    Salt TE; Binns KE; Turner JP; Gasparini F; Kuhn R
    Br J Pharmacol; 1999 Jul; 127(5):1057-9. PubMed ID: 10455248
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
    Schaffhauser H; Rowe BA; Morales S; Chavez-Noriega LE; Yin R; Jachec C; Rao SP; Bain G; Pinkerton AB; Vernier JM; Bristow LJ; Varney MA; Daggett LP
    Mol Pharmacol; 2003 Oct; 64(4):798-810. PubMed ID: 14500736
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.
    Mühlemann A; Ward NA; Kratochwil N; Diener C; Fischer C; Stucki A; Jaeschke G; Malherbe P; Porter RH
    Eur J Pharmacol; 2006 Jan; 529(1-3):95-104. PubMed ID: 16352303
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
    Battaglia G; Busceti CL; Molinaro G; Biagioni F; Storto M; Fornai F; Nicoletti F; Bruno V
    J Neurosci; 2004 Jan; 24(4):828-35. PubMed ID: 14749427
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.