BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 14505382)

  • 1. Designed helical peptides inhibit an intramembrane protease.
    Das C; Berezovska O; Diehl TS; Genet C; Buldyrev I; Tsai JY; Hyman BT; Wolfe MS
    J Am Chem Soc; 2003 Oct; 125(39):11794-5. PubMed ID: 14505382
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of gamma-secretase activity by helical beta-peptide foldamers.
    Imamura Y; Watanabe N; Umezawa N; Iwatsubo T; Kato N; Tomita T; Higuchi T
    J Am Chem Soc; 2009 Jun; 131(21):7353-9. PubMed ID: 19432477
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
    Bihel F; Das C; Bowman MJ; Wolfe MS
    J Med Chem; 2004 Jul; 47(16):3931-3. PubMed ID: 15267231
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
    Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW
    Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
    Wolfe MS; Citron M; Diehl TS; Xia W; Donkor IO; Selkoe DJ
    J Med Chem; 1998 Jan; 41(1):6-9. PubMed ID: 9438016
    [No Abstract]   [Full Text] [Related]  

  • 6. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
    Pollack SJ; Lewis H
    Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
    Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
    J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
    [TBL] [Abstract][Full Text] [Related]  

  • 8. gamma-Secretase as a target for drug intervention in Alzheimer's disease.
    Harrison T; Churcher I; Beher D
    Curr Opin Drug Discov Devel; 2004 Sep; 7(5):709-19. PubMed ID: 15503873
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
    Rajendran L; Schneider A; Schlechtingen G; Weidlich S; Ries J; Braxmeier T; Schwille P; Schulz JB; Schroeder C; Simons M; Jennings G; Knölker HJ; Simons K
    Science; 2008 Apr; 320(5875):520-3. PubMed ID: 18436784
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.
    Zuo Z; Luo X; Zhu W; Shen J; Shen X; Jiang H; Chen K
    Bioorg Med Chem; 2005 Mar; 13(6):2121-31. PubMed ID: 15727865
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The gamma-secretase complex: membrane-embedded proteolytic ensemble.
    Wolfe MS
    Biochemistry; 2006 Jul; 45(26):7931-9. PubMed ID: 16800619
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Gamma-secretase: a catalyst of Alzheimer disease and signal transduction.
    Li YM
    Mol Interv; 2001 Oct; 1(4):198-207. PubMed ID: 14993342
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Pathogenesis of Alzheimer's disease: implications from amyloid research front].
    Iwatsubo T
    Rinsho Shinkeigaku; 2004 Nov; 44(11):768-70. PubMed ID: 15651286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.
    Kimura T; Shuto D; Hamada Y; Igawa N; Kasai S; Liu P; Hidaka K; Hamada T; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2005 Jan; 15(1):211-5. PubMed ID: 15582441
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
    Bakshi P; Wolfe MS
    J Med Chem; 2004 Dec; 47(26):6485-9. PubMed ID: 15588083
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.
    Imamura Y; Umezawa N; Osawa S; Shimada N; Higo T; Yokoshima S; Fukuyama T; Iwatsubo T; Kato N; Tomita T; Higuchi T
    J Med Chem; 2013 Feb; 56(4):1443-54. PubMed ID: 23342950
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional plasticity in the substrate binding site of beta-secretase.
    Gorfe AA; Caflisch A
    Structure; 2005 Oct; 13(10):1487-98. PubMed ID: 16216580
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of gamma-secretase activity in Alzheimer's disease.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Biochemistry; 2007 Mar; 46(10):2553-63. PubMed ID: 17298085
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.