These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 14505666)

  • 1. Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.
    Desai RC; Gratale DF; Han W; Koyama H; Metzger E; Lombardo VK; MacNaul KL; Doebber TW; Berger JP; Leung K; Franklin R; Moller DE; Heck JV; Sahoo SP
    Bioorg Med Chem Lett; 2003 Oct; 13(20):3541-4. PubMed ID: 14505666
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.
    Desai RC; Han W; Metzger EJ; Bergman JP; Gratale DF; MacNaul KL; Berger JP; Doebber TW; Leung K; Moller DE; Heck JV; Sahoo SP
    Bioorg Med Chem Lett; 2003 Aug; 13(16):2795-8. PubMed ID: 12873517
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.
    Koyama H; Boueres JK; Han W; Metzger EJ; Bergman JP; Gratale DF; Miller DJ; Tolman RL; MacNaul KL; Berger JP; Doebber TW; Leung K; Moller DE; Heck JV; Sahoo SP
    Bioorg Med Chem Lett; 2003 May; 13(10):1801-4. PubMed ID: 12729668
    [TBL] [Abstract][Full Text] [Related]  

  • 4. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
    Henke BR; Blanchard SG; Brackeen MF; Brown KK; Cobb JE; Collins JL; Harrington WW; Hashim MA; Hull-Ryde EA; Kaldor I; Kliewer SA; Lake DH; Leesnitzer LM; Lehmann JM; Lenhard JM; Orband-Miller LA; Miller JF; Mook RA; Noble SA; Oliver W; Parks DJ; Plunket KD; Szewczyk JR; Willson TM
    J Med Chem; 1998 Dec; 41(25):5020-36. PubMed ID: 9836620
    [TBL] [Abstract][Full Text] [Related]  

  • 5. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
    Cobb JE; Blanchard SG; Boswell EG; Brown KK; Charifson PS; Cooper JP; Collins JL; Dezube M; Henke BR; Hull-Ryde EA; Lake DH; Lenhard JM; Oliver W; Oplinger J; Pentti M; Parks DJ; Plunket KD; Tong WQ
    J Med Chem; 1998 Dec; 41(25):5055-69. PubMed ID: 9836622
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Pingali H; Jain M; Shah S; Makadia P; Zaware P; Goel A; Patel M; Giri S; Patel H; Patel P
    Bioorg Med Chem; 2008 Aug; 16(15):7117-27. PubMed ID: 18625559
    [TBL] [Abstract][Full Text] [Related]  

  • 7. (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.
    Koyama H; Miller DJ; Boueres JK; Desai RC; Jones AB; Berger JP; MacNaul KL; Kelly LJ; Doebber TW; Wu MS; Zhou G; Wang PR; Ippolito MC; Chao YS; Agrawal AK; Franklin R; Heck JV; Wright SD; Moller DE; Sahoo SP
    J Med Chem; 2004 Jun; 47(12):3255-63. PubMed ID: 15163205
    [TBL] [Abstract][Full Text] [Related]  

  • 8. (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.
    Lohray BB; Lohray VB; Bajji AC; Kalchar S; Poondra RR; Padakanti S; Chakrabarti R; Vikramadithyan RK; Misra P; Juluri S; Mamidi NV; Rajagopalan R
    J Med Chem; 2001 Aug; 44(16):2675-8. PubMed ID: 11472221
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS; Almaden JV; Barnum SJ; Carlson TJ; Do QQ; Fraser JD; Hess M; Kim YH; Ogilvie KM; Sun S
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6116-9. PubMed ID: 16979341
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
    Collins JL; Blanchard SG; Boswell GE; Charifson PS; Cobb JE; Henke BR; Hull-Ryde EA; Kazmierski WM; Lake DH; Leesnitzer LM; Lehmann J; Lenhard JM; Orband-Miller LA; Gray-Nunez Y; Parks DJ; Plunkett KD; Tong WQ
    J Med Chem; 1998 Dec; 41(25):5037-54. PubMed ID: 9836621
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.
    Henke BR
    J Med Chem; 2004 Aug; 47(17):4118-27. PubMed ID: 15293980
    [No Abstract]   [Full Text] [Related]  

  • 12. Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS; Bailey S; Almaden JV; Barnum SJ; Carlson TJ; Christie LC; Do QQ; Fraser JD; Hess M; Kellum J; Kim YH; McClellan GA; Ogilvie KM; Simmons BH; Skalitzky D; Sun S; Wilhite D; Zehnder LR
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6120-3. PubMed ID: 16973358
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
    Sauerberg P; Pettersson I; Jeppesen L; Bury PS; Mogensen JP; Wassermann K; Brand CL; Sturis J; Wöldike HF; Fleckner J; Andersen AS; Mortensen SB; Svensson LA; Rasmussen HB; Lehmann SV; Polivka Z; Sindelar K; Panajotova V; Ynddal L; Wulff EM
    J Med Chem; 2002 Feb; 45(4):789-804. PubMed ID: 11831892
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation.
    Nugent C; Prins JB; Whitehead JP; Savage D; Wentworth JM; Chatterjee VK; O'Rahilly S
    Mol Endocrinol; 2001 Oct; 15(10):1729-38. PubMed ID: 11579205
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.
    Xu Y; Rito CJ; Etgen GJ; Ardecky RJ; Bean JS; Bensch WR; Bosley JR; Broderick CL; Brooks DA; Dominianni SJ; Hahn PJ; Liu S; Mais DE; Montrose-Rafizadeh C; Ogilvie KM; Oldham BA; Peters M; Rungta DK; Shuker AJ; Stephenson GA; Tripp AE; Wilson SB; Winneroski LL; Zink R; Kauffman RF; McCarthy JR
    J Med Chem; 2004 May; 47(10):2422-5. PubMed ID: 15115385
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
    Willson TM; Cobb JE; Cowan DJ; Wiethe RW; Correa ID; Prakash SR; Beck KD; Moore LB; Kliewer SA; Lehmann JM
    J Med Chem; 1996 Feb; 39(3):665-8. PubMed ID: 8576907
    [No Abstract]   [Full Text] [Related]  

  • 17. Peroxisome proliferator-activated receptor (PPAR) gamma agonists for diabetes.
    Moller DE; Greene DA
    Adv Protein Chem; 2001; 56():181-212. PubMed ID: 11329854
    [No Abstract]   [Full Text] [Related]  

  • 18. Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
    Adams AD; Yuen W; Hu Z; Santini C; Jones AB; MacNaul KL; Berger JP; Doebber TW; Moller DE
    Bioorg Med Chem Lett; 2003 Mar; 13(5):931-5. PubMed ID: 12617924
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.
    Liu KG; Lambert MH; Ayscue AH; Henke BR; Leesnitzer LM; Oliver WR; Plunket KD; Xu HE; Sternbach DD; Willson TM
    Bioorg Med Chem Lett; 2001 Dec; 11(24):3111-3. PubMed ID: 11720854
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
    Liu KG; Lambert MH; Leesnitzer LM; Oliver W; Ott RJ; Plunket KD; Stuart LW; Brown PJ; Willson TM; Sternbach DD
    Bioorg Med Chem Lett; 2001 Nov; 11(22):2959-62. PubMed ID: 11677135
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.