BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

443 related articles for article (PubMed ID: 14516196)

  • 1. The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
    Scapin G; Patel SB; Becker JW; Wang Q; Desponts C; Waddleton D; Skorey K; Cromlish W; Bayly C; Therien M; Gauthier JY; Li CS; Lau CK; Ramachandran C; Kennedy BP; Asante-Appiah E
    Biochemistry; 2003 Oct; 42(39):11451-9. PubMed ID: 14516196
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
    Burke TR; Ye B; Yan X; Wang S; Jia Z; Chen L; Zhang ZY; Barford D
    Biochemistry; 1996 Dec; 35(50):15989-96. PubMed ID: 8973169
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
    Liu G; Xin Z; Liang H; Abad-Zapatero C; Hajduk PJ; Janowick DA; Szczepankiewicz BG; Pei Z; Hutchins CW; Ballaron SJ; Stashko MA; Lubben TH; Berg CE; Rondinone CM; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 Jul; 46(16):3437-40. PubMed ID: 12877578
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.
    Szczepankiewicz BG; Liu G; Hajduk PJ; Abad-Zapatero C; Pei Z; Xin Z; Lubben TH; Trevillyan JM; Stashko MA; Ballaron SJ; Liang H; Huang F; Hutchins CW; Fesik SW; Jirousek MR
    J Am Chem Soc; 2003 Apr; 125(14):4087-96. PubMed ID: 12670229
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.
    Zhang S; Zhang ZY
    Drug Discov Today; 2007 May; 12(9-10):373-81. PubMed ID: 17467573
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allele-specific inhibitors of protein tyrosine phosphatases.
    Hoffman HE; Blair ER; Johndrow JE; Bishop AC
    J Am Chem Soc; 2005 Mar; 127(9):2824-5. PubMed ID: 15740097
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
    Wan ZK; Lee J; Xu W; Erbe DV; Joseph-McCarthy D; Follows BC; Zhang YL
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4941-5. PubMed ID: 16806920
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of a robust scintillation proximity assay for protein tyrosine phosphatase 1B using the catalytically inactive (C215S) mutant.
    Skorey KI; Kennedy BP; Friesen RW; Ramachandran C
    Anal Biochem; 2001 Apr; 291(2):269-78. PubMed ID: 11401301
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
    Wilson DP; Wan ZK; Xu WX; Kirincich SJ; Follows BC; Joseph-McCarthy D; Foreman K; Moretto A; Wu J; Zhu M; Binnun E; Zhang YL; Tam M; Erbe DV; Tobin J; Xu X; Leung L; Shilling A; Tam SY; Mansour TS; Lee J
    J Med Chem; 2007 Sep; 50(19):4681-98. PubMed ID: 17705360
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
    Maccari R; Ottanà R; Ciurleo R; Paoli P; Manao G; Camici G; Laggner C; Langer T
    ChemMedChem; 2009 Jun; 4(6):957-62. PubMed ID: 19288492
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The phosphatase domains of LAR, CD45, and PTP1B: structural correlations with peptide-based inhibitors.
    Glover NR; Tracey AS
    Biochem Cell Biol; 2000; 78(1):39-50. PubMed ID: 10735562
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
    Liu G; Szczepankiewicz BG; Pei Z; Janowick DA; Xin Z; Hajduk PJ; Abad-Zapatero C; Liang H; Hutchins CW; Fesik SW; Ballaron SJ; Stashko MA; Lubben T; Mika AK; Zinker BA; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 May; 46(11):2093-103. PubMed ID: 12747781
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidentate inhibitor.
    Liu GX; Tan JZ; Niu CY; Shen JH; Luo XM; Shen X; Chen KX; Jiang HL
    Acta Pharmacol Sin; 2006 Jan; 27(1):100-10. PubMed ID: 16364216
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one.
    Wang JF; Gong K; Wei DQ; Li YX; Chou KC
    Protein Eng Des Sel; 2009 Jun; 22(6):349-55. PubMed ID: 19380334
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies.
    Shim YS; Kim KC; Lee KA; Shrestha S; Lee KH; Kim CK; Cho H
    Bioorg Med Chem; 2005 Feb; 13(4):1325-32. PubMed ID: 15670940
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
    Rao GS; Ramachandran MV; Bajaj JS
    J Biomol Struct Dyn; 2006 Feb; 23(4):377-84. PubMed ID: 16363874
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.
    Taing M; Keng YF; Shen K; Wu L; Lawrence DS; Zhang ZY
    Biochemistry; 1999 Mar; 38(12):3793-803. PubMed ID: 10090769
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
    Liu G; Xin Z; Pei Z; Hajduk PJ; Abad-Zapatero C; Hutchins CW; Zhao H; Lubben TH; Ballaron SJ; Haasch DL; Kaszubska W; Rondinone CM; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 Sep; 46(20):4232-5. PubMed ID: 13678400
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
    Zhao H; Liu G; Xin Z; Serby MD; Pei Z; Szczepankiewicz BG; Hajduk PJ; Abad-Zapatero C; Hutchins CW; Lubben TH; Ballaron SJ; Haasch DL; Kaszubska W; Rondinone CM; Trevillyan JM; Jirousek MR
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5543-6. PubMed ID: 15482920
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comparative molecular similarity indices analysis (CoMSIA) studies of 1,2-naphthoquinone derivatives as PTP1B inhibitors.
    Sobhia ME; Bharatam PV
    Bioorg Med Chem; 2005 Mar; 13(6):2331-8. PubMed ID: 15727882
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.