BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

388 related articles for article (PubMed ID: 14519980)

  • 1. Cytotoxicity and DNA topoisomerase inhibitory activity of benz[f]indole-4,9-dione analogs.
    Park HJ; Lee HJ; Lee EJ; Hwang HJ; Shin SH; Suh ME; Kim C; Kim HJ; Seo EK; Lee SK
    Biosci Biotechnol Biochem; 2003 Sep; 67(9):1944-9. PubMed ID: 14519980
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.
    Park HJ; Kim YS; Kim JS; Lee EJ; Yi YJ; Hwang HJ; Suh ME; Ryu CK; Lee SK
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3385-8. PubMed ID: 15177438
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells.
    Lee EJ; Lee HJ; Park HJ; Min HY; Suh ME; Chung HJ; Lee SK
    Bioorg Med Chem Lett; 2004 Oct; 14(20):5175-8. PubMed ID: 15380222
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
    Kim JS; Rhee HK; Park HJ; Lee IK; Lee SK; Suh ME; Lee HJ; Ryu CK; Choo HY
    Bioorg Med Chem; 2007 Jan; 15(1):451-7. PubMed ID: 17035025
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.
    Shchekotikhin AE; Glazunova VA; Dezhenkova LG; Luzikov YN; Buyanov VN; Treshalina HM; Lesnaya NA; Romanenko VI; Kaluzhny DN; Balzarini J; Agama K; Pommier Y; Shtil AA; Preobrazhenskaya MN
    Eur J Med Chem; 2014 Oct; 86():797-805. PubMed ID: 25244612
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues.
    Song YL; Dong YF; Yang T; Zhang CC; Su LM; Huang X; Zhang DN; Yang GL; Liu YX
    Bioorg Med Chem; 2013 Dec; 21(24):7624-7. PubMed ID: 24262885
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and cytotoxicity evaluation of pyridin[2,3-f]indole-2,4,9-trione and benz[f]indole-2,4,9-trione derivatives.
    Lee HJ; Park SY; Kim JS; Song HM; Suh ME; Lee CO
    Bioorg Med Chem; 2003 Nov; 11(22):4791-6. PubMed ID: 14556795
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and cytotoxicity evaluation of 2-amino- and 2-hidroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives.
    Lee HJ; Suh ME; Lee CO
    Bioorg Med Chem; 2003 Apr; 11(7):1511-19. PubMed ID: 12628676
    [TBL] [Abstract][Full Text] [Related]  

  • 9. F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103.
    Etiévant C; Kruczynski A; Barret JM; Perrin D; van Hille B; Guminski Y; Hill BT
    Cancer Chemother Pharmacol; 2000; 46(2):101-13. PubMed ID: 10972479
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological evaluation of novel naphthoquinone fused cyclic aminoalkylphosphonates and aminoalkylphosphonic monoester.
    Wang B; Miao ZW; Wang J; Chen RY; Zhang XD
    Amino Acids; 2008 Aug; 35(2):463-8. PubMed ID: 17665273
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
    Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
    J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Indolocarbazole glycosides in inactive conformations.
    Facompré M; Carrasco C; Vezin H; Chisholm JD; Yoburn JC; Van Vranken DL; Bailly C
    Chembiochem; 2003 May; 4(5):386-95. PubMed ID: 12740810
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance.
    Shchekotikhin AE; Shtil AA; Luzikov YN; Bobrysheva TV; Buyanov VN; Preobrazhenskaya MN
    Bioorg Med Chem; 2005 Mar; 13(6):2285-91. PubMed ID: 15727877
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
    Zhu XK; Guan J; Tachibana Y; Bastow KF; Cho SJ; Cheng HH; Cheng YC; Gurwith M; Lee KH
    J Med Chem; 1999 Jul; 42(13):2441-6. PubMed ID: 10395485
    [TBL] [Abstract][Full Text] [Related]  

  • 16. New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.
    Cho HJ; Jung MJ; Woo S; Kim J; Lee ES; Kwon Y; Na Y
    Bioorg Med Chem; 2010 Feb; 18(3):1010-7. PubMed ID: 20093033
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of pyridino[2,3-f]indole-4,9-dione and 6,7-disubstituted quinoline-5,8-dione derivatives and evaluation on their cytotoxic activity.
    Suh ME; Park SY; Lee CO
    Bioorg Med Chem; 2001 Nov; 9(11):2979-86. PubMed ID: 11597479
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.
    Chen CL; Liu FL; Lee CC; Chen TC; Chang WW; Guh JH; Ahmed Ali AA; Chang DM; Huang HS
    Eur J Med Chem; 2014 Nov; 87():30-8. PubMed ID: 25240093
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: wakayin and tsitsikammamines.
    Legentil L; Benel L; Bertrand V; Lesur B; Delfourne E
    J Med Chem; 2006 May; 49(10):2979-88. PubMed ID: 16686539
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.
    Lafayette EA; de Almeida SMV; Cavalcanti Santos RV; de Oliveira JF; Amorim CADC; da Silva RMF; Pitta MGDR; Pitta IDR; de Moura RO; de Carvalho Júnior LB; de Melo Rêgo MJB; de Lima MDCA
    Eur J Med Chem; 2017 Aug; 136():511-522. PubMed ID: 28531811
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.