These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 14559095)

  • 41. Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay.
    Langsdorf EF; Malikzay A; Lamarr WA; Daubaras D; Kravec C; Zhang R; Hart R; Monsma F; Black T; Ozbal CC; Miesel L; Lunn CA
    J Biomol Screen; 2010 Jan; 15(1):52-61. PubMed ID: 20019290
    [TBL] [Abstract][Full Text] [Related]  

  • 42. NMR studies of DOXP reductoisomerase and its inhibitor complex.
    Englert NE; Richter C; Wiesner J; Hintz M; Jomaa H; Schwalbe H
    Chembiochem; 2011 Feb; 12(3):468-76. PubMed ID: 21290548
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Andaloussi M; Henriksson LM; Więckowska A; Lindh M; Björkelid C; Larsson AM; Suresh S; Iyer H; Srinivasa BR; Bergfors T; Unge T; Mowbray SL; Larhed M; Jones TA; Karlén A
    J Med Chem; 2011 Jul; 54(14):4964-76. PubMed ID: 21678907
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphoric acid analogues as alternate substrates for methylerythritol phosphate synthase.
    Fox DT; Poulter CD
    J Org Chem; 2005 Mar; 70(6):1978-85. PubMed ID: 15760175
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M; Ohtaki A; Noguchi K; Endo K; Sasaki Y; Ohsawa K; Yajima S; Yohda M
    J Struct Biol; 2010 Jun; 170(3):532-9. PubMed ID: 20353826
    [TBL] [Abstract][Full Text] [Related]  

  • 46. AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.
    Silber K; Heidler P; Kurz T; Klebe G
    J Med Chem; 2005 May; 48(10):3547-63. PubMed ID: 15887963
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Munos JW; Pu X; Liu HW
    Bioorg Med Chem Lett; 2008 May; 18(10):3090-4. PubMed ID: 18078746
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC.
    Erwin AL
    Cold Spring Harb Perspect Med; 2016 Jul; 6(7):. PubMed ID: 27235477
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
    Ponaire S; Zinglé C; Tritsch D; Grosdemange-Billiard C; Rohmer M
    Eur J Med Chem; 2012 May; 51():277-85. PubMed ID: 22405649
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Zinc metalloenzymes as new targets against the bacterial pathogen Brucella.
    Lopez M; Köhler S; Winum JY
    J Inorg Biochem; 2012 Jun; 111():138-45. PubMed ID: 22196018
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
    Andaloussi M; Lindh M; Björkelid C; Suresh S; Wieckowska A; Iyer H; Karlén A; Larhed M
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5403-7. PubMed ID: 21824775
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate analogues as chelation-based inhibitors of methylerythritol phosphate synthase.
    Walker JR; Poulter CD
    J Org Chem; 2005 Nov; 70(24):9955-9. PubMed ID: 16292827
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.
    Gillner DM; Becker DP; Holz RC
    J Biol Inorg Chem; 2013 Feb; 18(2):155-163. PubMed ID: 23223968
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
    Altincicek B; Hintz M; Sanderbrand S; Wiesner J; Beck E; Jomaa H
    FEMS Microbiol Lett; 2000 Sep; 190(2):329-33. PubMed ID: 11034300
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Targeting Metalloenzymes for Therapeutic Intervention.
    Chen AY; Adamek RN; Dick BL; Credille CV; Morrison CN; Cohen SM
    Chem Rev; 2019 Jan; 119(2):1323-1455. PubMed ID: 30192523
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR).
    Zinglé C; Kuntz L; Tritsch D; Grosdemange-Billiard C; Rohmer M
    Bioorg Med Chem Lett; 2012 Nov; 22(21):6563-7. PubMed ID: 23025997
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
    Lee CJ; Liang X; Chen X; Zeng D; Joo SH; Chung HS; Barb AW; Swanson SM; Nicholas RA; Li Y; Toone EJ; Raetz CR; Zhou P
    Chem Biol; 2011 Jan; 18(1):38-47. PubMed ID: 21167751
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Structural basis for the design of antibiotics targeting peptide deformylase.
    Hao B; Gong W; Rajagopalan PT; Zhou Y; Pei D; Chan MK
    Biochemistry; 1999 Apr; 38(15):4712-9. PubMed ID: 10200158
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Emerging bacterial enzyme targets.
    Su Z; Honek JF
    Curr Opin Investig Drugs; 2007 Feb; 8(2):140-9. PubMed ID: 17328230
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
    Chen MH; Steiner MG; de Laszlo SE; Patchett AA; Anderson MS; Hyland SA; Onishi HR; Silver LL; Raetz CR
    Bioorg Med Chem Lett; 1999 Feb; 9(3):313-8. PubMed ID: 10091675
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.