BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

291 related articles for article (PubMed ID: 14567631)

  • 1. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.
    Vig BS; Lorenzi PJ; Mittal S; Landowski CP; Shin HC; Mosberg HI; Hilfinger JM; Amidon GL
    Pharm Res; 2003 Sep; 20(9):1381-8. PubMed ID: 14567631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.
    Shin HC; Kim JS; Vig BS; Song X; Drach JC; Amidon GL
    Biol Pharm Bull; 2006 Feb; 29(2):247-52. PubMed ID: 16462026
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.
    Tsume Y; Hilfinger JM; Amidon GL
    Mol Pharm; 2008; 5(5):717-27. PubMed ID: 18652477
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.
    Landowski CP; Song X; Lorenzi PL; Hilfinger JM; Amidon GL
    Pharm Res; 2005 Sep; 22(9):1510-8. PubMed ID: 16132363
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.
    Landowski CP; Vig BS; Song X; Amidon GL
    Mol Cancer Ther; 2005 Apr; 4(4):659-67. PubMed ID: 15827340
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport.
    Song X; Lorenzi PL; Landowski CP; Vig BS; Hilfinger JM; Amidon GL
    Mol Pharm; 2005; 2(2):157-67. PubMed ID: 15804190
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nucleoside ester prodrug substrate specificity of liver carboxylesterase.
    Landowski CP; Lorenzi PL; Song X; Amidon GL
    J Pharmacol Exp Ther; 2006 Feb; 316(2):572-80. PubMed ID: 16223870
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chemical and enzymatic stability of amino acid prodrugs containing methoxy, ethoxy and propylene glycol linkers.
    Gupta D; Gupta SV; Lee KD; Amidon GL
    Mol Pharm; 2009; 6(5):1604-11. PubMed ID: 19566080
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.
    Han HK; Oh DM; Amidon GL
    Pharm Res; 1998 Sep; 15(9):1382-6. PubMed ID: 9755889
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability, and pharmacokinetics.
    Cao F; Gao Y; Wang M; Fang L; Ping Q
    Mol Pharm; 2013 Apr; 10(4):1378-87. PubMed ID: 23339520
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors.
    Hasabelnaby S; Goudah A; Agarwal HK; abd Alla MS; Tjarks W
    Eur J Med Chem; 2012 Sep; 55():325-34. PubMed ID: 22889558
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bifunctional and Unusual Amino Acid β- or γ-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB
    Sun Y; Ke Y; Li C; Wang J; Tu L; Hu L; Jin Y; Chen H; Gong J; Yu Z
    J Med Chem; 2020 Oct; 63(19):10816-10828. PubMed ID: 32882127
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Kinetics and mechanisms of activation of alpha-amino acid ester prodrugs of camptothecins.
    Song L; Bevins R; Anderson BD
    J Med Chem; 2006 Jul; 49(14):4344-55. PubMed ID: 16821794
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability.
    Tsume Y; Incecayir T; Song X; Hilfinger JM; Amidon GL
    Eur J Pharm Biopharm; 2014 Apr; 86(3):514-23. PubMed ID: 24361461
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of the ester moiety on stereoselective hydrolysis of several propranolol prodrugs in rat tissues.
    Takahashi K; Tamagawa S; Sakano H; Katagi T; Mizuno N
    Biol Pharm Bull; 1995 Oct; 18(10):1401-4. PubMed ID: 8593445
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.
    Kim I; Song X; Vig BS; Mittal S; Shin HC; Lorenzi PJ; Amidon GL
    Mol Pharm; 2004; 1(2):117-27. PubMed ID: 15832508
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility.
    Mahfouz NM; Hassan MA
    J Pharm Pharmacol; 2001 Jun; 53(6):841-8. PubMed ID: 11428660
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenates.
    Tsume Y; Amidon GL
    J Pharm Pharm Sci; 2012; 15(3):433-46. PubMed ID: 22974791
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, transport and pharmacokinetics of 5'-amino acid ester prodrugs of 1-beta-D-arabinofuranosylcytosine.
    Sun Y; Sun J; Shi S; Jing Y; Yin S; Chen Y; Li G; Xu Y; He Z
    Mol Pharm; 2009; 6(1):315-25. PubMed ID: 19115956
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A; Gudmundsson OS; Friis GJ; Siahaan TJ; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.