70 related articles for article (PubMed ID: 14567781)
1. A high-throughput method for enzyme kinetic studies.
Saraswat LD; Caserta KA; Laws K; Wei D; Jones SS; Adedoyin A
J Biomol Screen; 2003 Oct; 8(5):544-54. PubMed ID: 14567781
[TBL] [Abstract][Full Text] [Related]
2. Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
Zientek M; Miller H; Smith D; Dunklee MB; Heinle L; Thurston A; Lee C; Hyland R; Fahmi O; Burdette D
J Pharmacol Toxicol Methods; 2008; 58(3):206-14. PubMed ID: 18634893
[TBL] [Abstract][Full Text] [Related]
3. A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
Bhoopathy S; Xin B; Unger SE; Karnes HT
J Pharm Biomed Anal; 2005 Apr; 37(4):739-49. PubMed ID: 15797796
[TBL] [Abstract][Full Text] [Related]
4. An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
Youdim KA; Lyons R; Payne L; Jones BC; Saunders K
J Pharm Biomed Anal; 2008 Sep; 48(1):92-9. PubMed ID: 18584988
[TBL] [Abstract][Full Text] [Related]
5. Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
Zhang W; Han F; Guo P; Zhao H; Lin ZJ; Huang MQ; Bertelsen K; Weng N
J Chromatogr B Analyt Technol Biomed Life Sci; 2010 May; 878(15-16):1169-77. PubMed ID: 20378422
[TBL] [Abstract][Full Text] [Related]
6. Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
Mao J; Mohutsky MA; Harrelson JP; Wrighton SA; Hall SD
Drug Metab Dispos; 2012 Apr; 40(4):706-16. PubMed ID: 22228749
[TBL] [Abstract][Full Text] [Related]
7. Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
Brown HS; Chadwick A; Houston JB
Drug Metab Dispos; 2007 Nov; 35(11):2119-26. PubMed ID: 17724064
[TBL] [Abstract][Full Text] [Related]
8. Validated assays for human cytochrome P450 activities.
Walsky RL; Obach RS
Drug Metab Dispos; 2004 Jun; 32(6):647-60. PubMed ID: 15155557
[TBL] [Abstract][Full Text] [Related]
9. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.
Dierks EA; Stams KR; Lim HK; Cornelius G; Zhang H; Ball SE
Drug Metab Dispos; 2001 Jan; 29(1):23-9. PubMed ID: 11124225
[TBL] [Abstract][Full Text] [Related]
10. High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.
Kim MJ; Kim H; Cha IJ; Park JS; Shon JH; Liu KH; Shin JG
Rapid Commun Mass Spectrom; 2005; 19(18):2651-8. PubMed ID: 16124035
[TBL] [Abstract][Full Text] [Related]
11. Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries.
Jenkins KM; Angeles R; Quintos MT; Xu R; Kassel DB; Rourick RA
J Pharm Biomed Anal; 2004 Mar; 34(5):989-1004. PubMed ID: 15019033
[TBL] [Abstract][Full Text] [Related]
12. Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
Weaver R; Graham KS; Beattie IG; Riley RJ
Drug Metab Dispos; 2003 Jul; 31(7):955-66. PubMed ID: 12814974
[TBL] [Abstract][Full Text] [Related]
13. Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design.
Perloff ES; Mason AK; Dehal SS; Blanchard AP; Morgan L; Ho T; Dandeneau A; Crocker RM; Chandler CM; Boily N; Crespi CL; Stresser DM
Xenobiotica; 2009 Feb; 39(2):99-112. PubMed ID: 19255936
[TBL] [Abstract][Full Text] [Related]
14. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.
Li X; Chen X; Li Q; Wang L; Zhong D
J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jun; 852(1-2):128-37. PubMed ID: 17267297
[TBL] [Abstract][Full Text] [Related]
15. Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Martínez C; Albet C; Agúndez JA; Herrero E; Carrillo JA; Márquez M; Benítez J; Ortiz JA
Clin Pharmacol Ther; 1999 Apr; 65(4):369-76. PubMed ID: 10223772
[TBL] [Abstract][Full Text] [Related]
16. Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe.
Chauret N; Tremblay N; Lackman RL; Gauthier JY; Silva JM; Marois J; Yergey JA; Nicoll-Griffith DA
Anal Biochem; 1999 Dec; 276(2):215-26. PubMed ID: 10603245
[TBL] [Abstract][Full Text] [Related]
17. High-throughput cytochrome p450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columns.
Peng SX; Barbone AG; Ritchie DM
Rapid Commun Mass Spectrom; 2003; 17(6):509-18. PubMed ID: 12621611
[TBL] [Abstract][Full Text] [Related]
18. Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development.
Mori K; Hashimoto H; Takatsu H; Tsuda-Tsukimoto M; Kume T
Xenobiotica; 2009 Jun; 39(6):415-22. PubMed ID: 19480547
[TBL] [Abstract][Full Text] [Related]
19. High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis.
Halladay JS; Delarosa EM; Tran D; Wang L; Wong S; Khojasteh SC
Drug Metab Lett; 2011 Aug; 5(3):220-30. PubMed ID: 21867481
[TBL] [Abstract][Full Text] [Related]
20. Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis.
Jónsdóttir SÓ; Ringsted T; Nikolov NG; Dybdahl M; Wedebye EB; Niemelä JR
Bioorg Med Chem; 2012 Mar; 20(6):2042-53. PubMed ID: 22364953
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
