BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

223 related articles for article (PubMed ID: 14581373)

  • 1. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.
    Sanghani SP; Quinney SK; Fredenburg TB; Sun Z; Davis WI; Murry DJ; Cummings OW; Seitz DE; Bosron WF
    Clin Cancer Res; 2003 Oct; 9(13):4983-91. PubMed ID: 14581373
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
    Sanghani SP; Quinney SK; Fredenburg TB; Davis WI; Murry DJ; Bosron WF
    Drug Metab Dispos; 2004 May; 32(5):505-11. PubMed ID: 15100172
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expression and characterization of a human carboxylesterase 2 splice variant.
    Schiel MA; Green SL; Davis WI; Sanghani PC; Bosron WF; Sanghani SP
    J Pharmacol Exp Ther; 2007 Oct; 323(1):94-101. PubMed ID: 17636009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.
    Xu G; Zhang W; Ma MK; McLeod HL
    Clin Cancer Res; 2002 Aug; 8(8):2605-11. PubMed ID: 12171891
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants.
    Jansen WJ; Zwart B; Hulscher ST; Giaccone G; Pinedo HM; Boven E
    Int J Cancer; 1997 Jan; 70(3):335-40. PubMed ID: 9033637
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues.
    Guichard S; Terret C; Hennebelle I; Lochon I; Chevreau P; Frétigny E; Selves J; Chatelut E; Bugat R; Canal P
    Br J Cancer; 1999 May; 80(3-4):364-70. PubMed ID: 10408839
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity.
    Hennebelle I; Terret C; Chatelut E; Bugat R; Canal P; Guichard S
    Anticancer Drugs; 2000 Jul; 11(6):465-70. PubMed ID: 11001387
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.
    Tanimoto K; Kaneyasu M; Shimokuni T; Hiyama K; Nishiyama M
    Pharmacogenet Genomics; 2007 Jan; 17(1):1-10. PubMed ID: 17264798
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.
    Quinney SK; Sanghani SP; Davis WI; Hurley TD; Sun Z; Murry DJ; Bosron WF
    J Pharmacol Exp Ther; 2005 Jun; 313(3):1011-6. PubMed ID: 15687373
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.
    Liu D; Gao J; Zhang C; Ren X; Liu Y; Xu Y
    Pharmazie; 2011 Nov; 66(11):888-93. PubMed ID: 22204136
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
    Humerickhouse R; Lohrbach K; Li L; Bosron WF; Dolan ME
    Cancer Res; 2000 Mar; 60(5):1189-92. PubMed ID: 10728672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presence and inter-individual variability of carboxylesterases (CES1 and CES2) in human lung.
    Gabriele M; Puccini P; Lucchi M; Vizziello A; Gervasi PG; Longo V
    Biochem Pharmacol; 2018 Apr; 150():64-71. PubMed ID: 29407485
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2.
    Wang J; Williams ET; Bourgea J; Wong YN; Patten CJ
    Drug Metab Dispos; 2011 Aug; 39(8):1329-33. PubMed ID: 21540359
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions.
    Slatter JG; Su P; Sams JP; Schaaf LJ; Wienkers LC
    Drug Metab Dispos; 1997 Oct; 25(10):1157-64. PubMed ID: 9321519
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
    Oosterhoff D; Pinedo HM; van der Meulen IH; de Graaf M; Sone T; Kruyt FA; van Beusechem VW; Haisma HJ; Gerritsen WR
    Br J Cancer; 2002 Sep; 87(6):659-64. PubMed ID: 12237777
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Carboxylesterase isoform 2 mRNA expression in peripheral blood mononuclear cells is a predictive marker of the irinotecan to SN38 activation step in colorectal cancer patients.
    Cecchin E; Corona G; Masier S; Biason P; Cattarossi G; Frustaci S; Buonadonna A; Colussi A; Toffoli G
    Clin Cancer Res; 2005 Oct; 11(19 Pt 1):6901-7. PubMed ID: 16203781
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases.
    Crow JA; Borazjani A; Potter PM; Ross MK
    Toxicol Appl Pharmacol; 2007 May; 221(1):1-12. PubMed ID: 17442360
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1.
    Sun Z; Murry DJ; Sanghani SP; Davis WI; Kedishvili NY; Zou Q; Hurley TD; Bosron WF
    J Pharmacol Exp Ther; 2004 Aug; 310(2):469-76. PubMed ID: 15082749
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.
    Hatfield MJ; Tsurkan L; Hyatt JL; Yu X; Edwards CC; Hicks LD; Wadkins RM; Potter PM
    Br J Pharmacol; 2010 Aug; 160(8):1916-28. PubMed ID: 20649590
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Clinical implications of CES2 RNA expression in neuroblastoma.
    Uchida K; Otake K; Tanaka K; Hashimoto K; Saigusa S; Matsushita K; Koike Y; Inoue M; Ueeda M; Okugawa Y; Inoue Y; Mohri Y; Kusunoki M
    J Pediatr Surg; 2013 Mar; 48(3):502-9. PubMed ID: 23480903
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.