BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 14583265)

  • 1. Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase.
    Jacques SL; Mirza IA; Ejim L; Koteva K; Hughes DW; Green K; Kinach R; Honek JF; Lai HK; Berghuis AM; Wright GD
    Chem Biol; 2003 Oct; 10(10):989-95. PubMed ID: 14583265
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae.
    Yamaki H; Yamaguchi M; Tsuruo T; Yamaguchi H
    J Antibiot (Tokyo); 1992 May; 45(5):750-5. PubMed ID: 1352515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex.
    Ogata K; Yajima Y; Nakamura S; Kaneko R; Goto M; Ohshima T; Yoshimune K
    Sci Rep; 2018 Apr; 8(1):5749. PubMed ID: 29636528
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor.
    Bareich DC; Nazi I; Wright GD
    Chem Biol; 2003 Oct; 10(10):967-73. PubMed ID: 14583263
    [No Abstract]   [Full Text] [Related]  

  • 5. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
    DeLaBarre B; Thompson PR; Wright GD; Berghuis AM
    Nat Struct Biol; 2000 Mar; 7(3):238-44. PubMed ID: 10700284
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
    Jacques SL; Nieman C; Bareich D; Broadhead G; Kinach R; Honek JF; Wright GD
    Biochim Biophys Acta; 2001 Jan; 1544(1-2):28-41. PubMed ID: 11341914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase.
    Skwarecki AS; Schielmann M; Martynow D; Kawczyński M; Wiśniewska A; Milewska MJ; Milewski S
    J Pept Sci; 2018 Jan; 24(1):. PubMed ID: 29322651
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer.
    Jacques SL; Ejim LJ; Wright GD
    Biochim Biophys Acta; 2001 Jan; 1544(1-2):42-54. PubMed ID: 11341915
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae.
    Yamaki H; Yamaguchi M; Imamura H; Suzuki H; Nishimura T; Saito H; Yamaguchi H
    Biochem Biophys Res Commun; 1990 Apr; 168(2):837-43. PubMed ID: 1970730
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New phenolic inhibitors of yeast homoserine dehydrogenase.
    Ejim L; Mirza IA; Capone C; Nazi I; Jenkins S; Chee GL; Berghuis AM; Wright GD
    Bioorg Med Chem; 2004 Jul; 12(14):3825-30. PubMed ID: 15210149
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Exploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening study.
    Zhan D; Wang D; Min W; Han W
    Int J Mol Sci; 2014 Jan; 15(2):1826-41. PubMed ID: 24469317
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for the catalytic mechanism of homoserine dehydrogenase.
    Navratna V; Reddy G; Gopal B
    Acta Crystallogr D Biol Crystallogr; 2015 May; 71(Pt 5):1216-25. PubMed ID: 25945586
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting the Homoserine Dehydrogenase of Paracoccidioides Species for Treatment of Systemic Fungal Infections.
    Bagatin MC; Pimentel AL; Biavatti DC; Basso EA; Kioshima ES; Seixas FAV; Gauze GF
    Antimicrob Agents Chemother; 2017 Sep; 61(9):. PubMed ID: 28652239
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases.
    Hayashi J; Inoue S; Kim K; Yoneda K; Kawarabayasi Y; Ohshima T; Sakuraba H
    Sci Rep; 2015 Jul; 5():11674. PubMed ID: 26154028
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The crystal structure of homoserine dehydrogenase complexed with l-homoserine and NADPH in a closed form.
    Akai S; Ikushiro H; Sawai T; Yano T; Kamiya N; Miyahara I
    J Biochem; 2019 Feb; 165(2):185-195. PubMed ID: 30423116
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.
    Benach J; Atrian S; Gonzàlez-Duarte R; Ladenstein R
    J Mol Biol; 1999 Jun; 289(2):335-55. PubMed ID: 10366509
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nutrient effects on growth and the production of 5-hydroxy-4-oxonorvaline by Streptomyces akiyoshiensis.
    Glazebrook MA; Vining LC; White RL; Smith KC; Chedrawy EG
    Can J Microbiol; 1993 May; 39(5):536-42. PubMed ID: 8330263
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic mechanism, and in vivo activity.
    Schroeder AC; Zhu C; Yanamadala SR; Cahoon RE; Arkus KA; Wachsstock L; Bleeke J; Krishnan HB; Jez JM
    J Biol Chem; 2010 Jan; 285(2):827-34. PubMed ID: 19897476
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of substrates and inhibitors with the homoserine dehydrogenase of kinase-inactivated aspartokinase I.
    Wright JK; Takahashi M
    Biochemistry; 1977 Apr; 16(8):1541-8. PubMed ID: 192265
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rational design of allosteric regulation of homoserine dehydrogenase by a nonnatural inhibitor L-lysine.
    Chen Z; Rappert S; Zeng AP
    ACS Synth Biol; 2015 Feb; 4(2):126-31. PubMed ID: 24344690
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.