BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 14592483)

  • 1. Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A; Ramulu P; Srinivas O; Ramesh G
    Bioorg Med Chem Lett; 2003 Nov; 13(22):3955-8. PubMed ID: 14592483
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP; Kumar MS
    Bioorg Med Chem; 2004 Aug; 12(16):4337-50. PubMed ID: 15265486
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
    Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
    Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
    J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Gregson SJ; Howard PW; Thurston DE
    Bioorg Med Chem Lett; 2003 Jul; 13(14):2277-80. PubMed ID: 12824017
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.
    Kamal A; Shankaraiah N; Prabhakar S; Reddy ChR; Markandeya N; Reddy KL; Devaiah V
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2434-9. PubMed ID: 18325766
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.
    Kamal A; Shankaraiah N; Devaiah V; Laxma Reddy K; Juvekar A; Sen S; Kurian N; Zingde S
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1468-73. PubMed ID: 18207392
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
    Gregson SJ; Howard PW; Corcoran KE; Jenkins TC; Kelland LR; Thurston DE
    Bioorg Med Chem Lett; 2001 Nov; 11(21):2859-62. PubMed ID: 11597416
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids.
    Kamal A; Ramesh G; Srinivas O; Ramulu P
    Bioorg Med Chem Lett; 2004 Jan; 14(2):471-4. PubMed ID: 14698184
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
    Kamal A; Ramu R; Khanna GB; Saxena AK; Shanmugavel M; Pandita RM
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4907-9. PubMed ID: 15341949
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
    Kamal A; Khan MN; Srikanth YV; Reddy KS; Juvekar A; Sen S; Kurian N; Zingde S
    Bioorg Med Chem; 2008 Aug; 16(16):7804-10. PubMed ID: 18657979
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
    Wilson SC; Howard PW; Forrow SM; Hartley JA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
    J Med Chem; 1999 Oct; 42(20):4028-41. PubMed ID: 10514273
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
    Antonow D; Kaliszczak M; Kang GD; Coffils M; Tiberghien AC; Cooper N; Barata T; Heidelberger S; James CH; Zloh M; Jenkins TC; Reszka AP; Neidle S; Guichard SM; Jodrell DI; Hartley JA; Howard PW; Thurston DE
    J Med Chem; 2010 Apr; 53(7):2927-41. PubMed ID: 20218628
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: synthesis, DNA-binding affinity and cytotoxic activity.
    Kamal A; Sreekanth K; Shankaraiah N; Sathish M; Nekkanti S; Srinivasulu V
    Bioorg Chem; 2015 Apr; 59():23-30. PubMed ID: 25665519
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
    Tiberghien AC; Evans DA; Kiakos K; Martin CR; Hartley JA; Thurston DE; Howard PW
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2073-7. PubMed ID: 18272367
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
    Kumar R; Lown JW
    Mini Rev Med Chem; 2003 Jun; 3(4):323-39. PubMed ID: 12678826
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents.
    Kamal A; Ramesh G; Ramulu P; Srinivas O; Rehana T; Sheelu G
    Bioorg Med Chem Lett; 2003 Oct; 13(20):3451-4. PubMed ID: 14505647
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines.
    Varvounis G
    Molecules; 2016 Jan; 21(2):154. PubMed ID: 26828475
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.
    Masterson LA; Croker SJ; Jenkins TC; Howard PW; Thurston DE
    Bioorg Med Chem Lett; 2004 Feb; 14(4):901-4. PubMed ID: 15012990
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis of benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines as DNA-binding and potential anticancer agents.
    Kamal A; Rajender ; Reddy MK; Reddy VS; Kumar GB
    Med Chem; 2013 Mar; 9(2):177-92. PubMed ID: 22931493
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.