BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

105 related articles for article (PubMed ID: 14592488)

  • 1. Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.
    Llauger-Bufi L; Felts SJ; Huezo H; Rosen N; Chiosis G
    Bioorg Med Chem Lett; 2003 Nov; 13(22):3975-8. PubMed ID: 14592488
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of Hsp90 dimerization modulators.
    Chiosis G; Aguirre J; Nicchitta CV
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3529-32. PubMed ID: 16621545
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
    Moulick K; Clement CC; Aguirre J; Kim J; Kang Y; Felts S; Chiosis G
    Bioorg Med Chem Lett; 2006 Sep; 16(17):4515-8. PubMed ID: 16797988
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of a fluorescence polarization assay for the molecular chaperone Hsp90.
    Kim J; Felts S; Llauger L; He H; Huezo H; Rosen N; Chiosis G
    J Biomol Screen; 2004 Aug; 9(5):375-81. PubMed ID: 15296636
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism.
    Schulze A; Beliu G; Helmerich DA; Schubert J; Pearl LH; Prodromou C; Neuweiler H
    Nat Chem Biol; 2016 Aug; 12(8):628-35. PubMed ID: 27322067
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro evidence that hsp90 contains two independent chaperone sites.
    Young JC; Schneider C; Hartl FU
    FEBS Lett; 1997 Nov; 418(1-2):139-43. PubMed ID: 9414113
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and evaluation of small molecule Hsp90 probes.
    Taldone T; Zatorska D; Patel PD; Zong H; Rodina A; Ahn JH; Moulick K; Guzman ML; Chiosis G
    Bioorg Med Chem; 2011 Apr; 19(8):2603-14. PubMed ID: 21459002
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors.
    Koay YC; Wahyudi H; McAlpine SR
    Chemistry; 2016 Dec; 22(51):18572-18582. PubMed ID: 27859703
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP90.
    Ishida R; Takaoka Y; Yamamoto S; Miyazaki T; Otaka M; Watanabe S; Komatsuda A; Wakui H; Sawada K; Kubota H; Itoh H
    FEBS Lett; 2008 Nov; 582(28):3879-83. PubMed ID: 18955054
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity.
    Yokoyama Y; Ohtaki A; Jantan I; Yohda M; Nakamoto H
    J Biochem; 2015 Mar; 157(3):161-8. PubMed ID: 25294885
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
    Ganesh T; Min J; Thepchatri P; Du Y; Li L; Lewis I; Wilson L; Fu H; Chiosis G; Dingledine R; Liotta D; Snyder JP; Sun A
    Bioorg Med Chem; 2008 Jul; 16(14):6903-10. PubMed ID: 18571929
    [TBL] [Abstract][Full Text] [Related]  

  • 12. [Heat shock protein 90: novel target for cancer therapy].
    Chen Y; Ding J
    Ai Zheng; 2004 Aug; 23(8):968-74. PubMed ID: 15301726
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
    Dymock BW; Barril X; Brough PA; Cansfield JE; Massey A; McDonald E; Hubbard RE; Surgenor A; Roughley SD; Webb P; Workman P; Wright L; Drysdale MJ
    J Med Chem; 2005 Jun; 48(13):4212-5. PubMed ID: 15974572
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Both the N- and C-terminal chaperone sites of Hsp90 participate in protein refolding.
    Minami M; Nakamura M; Emori Y; Minami Y
    Eur J Biochem; 2001 Apr; 268(8):2520-4. PubMed ID: 11298772
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
    Meyer P; Prodromou C; Liao C; Hu B; Mark Roe S; Vaughan CK; Vlasic I; Panaretou B; Piper PW; Pearl LH
    EMBO J; 2004 Feb; 23(3):511-9. PubMed ID: 14739935
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.
    Schulte TW; Akinaga S; Soga S; Sullivan W; Stensgard B; Toft D; Neckers LM
    Cell Stress Chaperones; 1998 Jun; 3(2):100-8. PubMed ID: 9672245
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.
    Armstrong HK; Koay YC; Irani S; Das R; Nassar ZD; ; Selth LA; Centenera MM; McAlpine SR; Butler LM
    Prostate; 2016 Dec; 76(16):1546-1559. PubMed ID: 27526951
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.
    Taldone T; Gomes-DaGama EM; Zong H; Sen S; Alpaugh ML; Zatorska D; Alonso-Sabadell R; Guzman ML; Chiosis G
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5347-52. PubMed ID: 21802945
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.
    Itoh H; Ogura M; Komatsuda A; Wakui H; Miura AB; Tashima Y
    Biochem J; 1999 Nov; 343 Pt 3(Pt 3):697-703. PubMed ID: 10527951
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation.
    Goode KM; Petrov DP; Vickman RE; Crist SA; Pascuzzi PE; Ratliff TL; Davisson VJ; Hazbun TR
    Biochim Biophys Acta Gen Subj; 2017 Aug; 1861(8):1992-2006. PubMed ID: 28495207
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.