BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 14596677)

  • 1. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
    Hirashima Y; Tsuruzoe K; Kodama S; Igata M; Toyonaga T; Ueki K; Kahn CR; Araki E
    J Endocrinol; 2003 Nov; 179(2):253-66. PubMed ID: 14596677
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.
    Kurihara S; Hakuno F; Takahashi S
    Endocr J; 2000 Dec; 47(6):739-51. PubMed ID: 11228049
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.
    Schnyder B; Lahm H; Pittet M; Schnyder-Candrian S
    J Recept Signal Transduct Res; 2002; 22(1-4):213-28. PubMed ID: 12503617
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells.
    Roques M; Vidal H
    J Biol Chem; 1999 Nov; 274(48):34005-10. PubMed ID: 10567366
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
    Gingras S; Côté S; Simard J
    Mol Endocrinol; 2000 Feb; 14(2):229-40. PubMed ID: 10674396
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.
    Matsumoto M; Ogawa W; Teshigawara K; Inoue H; Miyake K; Sakaue H; Kasuga M
    Diabetes; 2002 Jun; 51(6):1672-80. PubMed ID: 12031952
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
    Ozes ON; Akca H; Mayo LD; Gustin JA; Maehama T; Dixon JE; Donner DB
    Proc Natl Acad Sci U S A; 2001 Apr; 98(8):4640-5. PubMed ID: 11287630
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
    Pirola L; Bonnafous S; Johnston AM; Chaussade C; Portis F; Van Obberghen E
    J Biol Chem; 2003 May; 278(18):15641-51. PubMed ID: 12594228
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway.
    Uddin S; Majchrzak B; Wang PC; Modi S; Khan MK; Fish EN; Platanias LC
    Biochem Biophys Res Commun; 2000 Apr; 270(1):158-62. PubMed ID: 10733921
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
    Takano A; Usui I; Haruta T; Kawahara J; Uno T; Iwata M; Kobayashi M
    Mol Cell Biol; 2001 Aug; 21(15):5050-62. PubMed ID: 11438661
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
    Haruta T; Uno T; Kawahara J; Takano A; Egawa K; Sharma PM; Olefsky JM; Kobayashi M
    Mol Endocrinol; 2000 Jun; 14(6):783-94. PubMed ID: 10847581
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PTEN expression causes feedback upregulation of insulin receptor substrate 2.
    Simpson L; Li J; Liaw D; Hennessy I; Oliner J; Christians F; Parsons R
    Mol Cell Biol; 2001 Jun; 21(12):3947-58. PubMed ID: 11359902
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
    Greene MW; Sakaue H; Wang L; Alessi DR; Roth RA
    J Biol Chem; 2003 Mar; 278(10):8199-211. PubMed ID: 12510059
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
    Fasshauer M; Klein J; Kriauciunas KM; Ueki K; Benito M; Kahn CR
    Mol Cell Biol; 2001 Jan; 21(1):319-29. PubMed ID: 11113206
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin.
    Scassa ME; Guberman AS; Varone CL; Cánepa ET
    Exp Cell Res; 2001 Dec; 271(2):201-13. PubMed ID: 11716532
    [TBL] [Abstract][Full Text] [Related]  

  • 16. GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
    Annerén C; Welsh M
    Mol Med; 2002 Nov; 8(11):705-13. PubMed ID: 12520087
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts.
    Yamane K; Ihn H; Tamaki K
    Arthritis Rheum; 2003 Jun; 48(6):1652-66. PubMed ID: 12794834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
    Valverde AM; Burks DJ; Fabregat I; Fisher TL; Carretero J; White MF; Benito M
    Diabetes; 2003 Sep; 52(9):2239-48. PubMed ID: 12941762
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
    Tsuruzoe K; Emkey R; Kriauciunas KM; Ueki K; Kahn CR
    Mol Cell Biol; 2001 Jan; 21(1):26-38. PubMed ID: 11113178
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis.
    Kaburagi Y; Satoh S; Yamamoto-Honda R; Ito Y; Akanuma Y; Sekihara H; Yasuda K; Sasazuki T; Kadowaki T; Yazaki Y
    Biochem Biophys Res Commun; 2003 Jan; 300(2):371-7. PubMed ID: 12504093
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.