BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

888 related articles for article (PubMed ID: 14598314)

  • 1. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J; Williamson NA; Hill AF; Sernee MF; Masters CL; Small DH
    J Neurosci Res; 2003 Nov; 74(3):378-85. PubMed ID: 14598314
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
    Nunan J; Shearman MS; Checler F; Cappai R; Evin G; Beyreuther K; Masters CL; Small DH
    Eur J Biochem; 2001 Oct; 268(20):5329-36. PubMed ID: 11606195
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW
    J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.
    Kouchi Z; Sorimachi H; Suzuki K; Ishiura S
    Biochem Biophys Res Commun; 1999 Jan; 254(3):804-10. PubMed ID: 9920821
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
    Funamoto S; Morishima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; Ihara Y
    Biochemistry; 2004 Oct; 43(42):13532-40. PubMed ID: 15491160
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H; Maruyama K; Kametani F
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P; Feyt C; Huysseune S; de Diesbach P; N'Kuli F; Courtoy PJ; Octave JN
    J Neurosci Res; 2006 Nov; 84(6):1311-22. PubMed ID: 16941495
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Iizuka T; Shoji M; Kawarabayashi T; Sato M; Kobayashi T; Tada N; Kasai K; Matsubara E; Watanabe M; Tomidokoro Y; Hirai S
    Biochem Biophys Res Commun; 1996 Jan; 218(1):238-42. PubMed ID: 8573139
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
    Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
    Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.
    Cantone JL; Xu-Lin A; Toyn JH; Drexler DM
    J Neurosci Methods; 2009 Jun; 180(2):255-60. PubMed ID: 19464516
    [TBL] [Abstract][Full Text] [Related]  

  • 17. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
    Jäger S; Leuchtenberger S; Martin A; Czirr E; Wesselowski J; Dieckmann M; Waldron E; Korth C; Koo EH; Heneka M; Weggen S; Pietrzik CU
    J Neurochem; 2009 Dec; 111(6):1369-82. PubMed ID: 19804379
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 19. gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting.
    Kume H; Sekijima Y; Maruyama K; Kametani F
    Int J Mol Med; 2003 Jul; 12(1):57-60. PubMed ID: 12792809
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the multicatalytic enzyme as a possible gamma-secretase for the amyloid precursor protein.
    Mundy DI
    Biochem Biophys Res Commun; 1994 Oct; 204(1):333-41. PubMed ID: 7945379
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 45.