These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
138 related articles for article (PubMed ID: 14602727)
1. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; Steiner H; Haass C J Biol Chem; 2003 Dec; 278(52):52519-23. PubMed ID: 14602727 [TBL] [Abstract][Full Text] [Related]
2. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation. Walker ES; Martinez M; Wang J; Goate A J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816 [TBL] [Abstract][Full Text] [Related]
3. Gamma-secretase activity is associated with a conformational change of nicastrin. Shirotani K; Edbauer D; Capell A; Schmitz J; Steiner H; Haass C J Biol Chem; 2003 May; 278(19):16474-7. PubMed ID: 12644462 [TBL] [Abstract][Full Text] [Related]
4. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; Lee VM; Doms RW J Biol Chem; 2003 Oct; 278(44):43284-91. PubMed ID: 12917438 [TBL] [Abstract][Full Text] [Related]
5. Gamma-secretase complex assembly within the early secretory pathway. Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316 [TBL] [Abstract][Full Text] [Related]
6. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. Li T; Ma G; Cai H; Price DL; Wong PC J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934 [TBL] [Abstract][Full Text] [Related]
7. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. Kaether C; Capell A; Edbauer D; Winkler E; Novak B; Steiner H; Haass C EMBO J; 2004 Dec; 23(24):4738-48. PubMed ID: 15549135 [TBL] [Abstract][Full Text] [Related]
8. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. Kim SH; Yin YI; Li YM; Sisodia SS J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788 [TBL] [Abstract][Full Text] [Related]
9. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. Steiner H; Winkler E; Edbauer D; Prokop S; Basset G; Yamasaki A; Kostka M; Haass C J Biol Chem; 2002 Oct; 277(42):39062-5. PubMed ID: 12198112 [TBL] [Abstract][Full Text] [Related]
10. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. Zhang X; Sullivan E; Scimeca M; Wu X; Li YM; Sisodia SS J Biol Chem; 2016 Mar; 291(13):6748-53. PubMed ID: 26887941 [TBL] [Abstract][Full Text] [Related]
11. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764 [TBL] [Abstract][Full Text] [Related]
12. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673 [TBL] [Abstract][Full Text] [Related]
13. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Edbauer D; Winkler E; Haass C; Steiner H Proc Natl Acad Sci U S A; 2002 Jun; 99(13):8666-71. PubMed ID: 12048259 [TBL] [Abstract][Full Text] [Related]
14. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355 [TBL] [Abstract][Full Text] [Related]
15. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015 [TBL] [Abstract][Full Text] [Related]
16. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134 [TBL] [Abstract][Full Text] [Related]
17. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. Kim SH; Ikeuchi T; Yu C; Sisodia SS J Biol Chem; 2003 Sep; 278(36):33992-4002. PubMed ID: 12821663 [TBL] [Abstract][Full Text] [Related]
18. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. Edbauer D; Kaether C; Steiner H; Haass C J Biol Chem; 2004 Sep; 279(36):37311-5. PubMed ID: 15210705 [TBL] [Abstract][Full Text] [Related]
19. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H J Biol Chem; 2004 May; 279(22):23255-61. PubMed ID: 15039426 [TBL] [Abstract][Full Text] [Related]
20. The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity. Bergman A; Laudon H; Winblad B; Lundkvist J; Näslund J J Biol Chem; 2004 Oct; 279(44):45564-72. PubMed ID: 15322123 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]