109 related articles for article (PubMed ID: 14604813)
1. Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
Lingohr MK; Dickson LM; Wrede CE; Briaud I; McCuaig JF; Myers MG; Rhodes CJ
Mol Cell Endocrinol; 2003 Nov; 209(1-2):17-31. PubMed ID: 14604813
[TBL] [Abstract][Full Text] [Related]
2. IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
Lingohr MK; Dickson LM; Wrede CE; McCuaig JF; Myers MG; Rhodes CJ
Mol Cell Endocrinol; 2003 Jun; 204(1-2):85-99. PubMed ID: 12850284
[TBL] [Abstract][Full Text] [Related]
3. Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
Lingohr MK; Dickson LM; McCuaig JF; Hugl SR; Twardzik DR; Rhodes CJ
Diabetes; 2002 Apr; 51(4):966-76. PubMed ID: 11916914
[TBL] [Abstract][Full Text] [Related]
4. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
Wrede CE; Dickson LM; Lingohr MK; Briaud I; Rhodes CJ
J Biol Chem; 2002 Dec; 277(51):49676-84. PubMed ID: 12393870
[TBL] [Abstract][Full Text] [Related]
5. Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
Cousin SP; Hügl SR; Wrede CE; Kajio H; Myers MG; Rhodes CJ
Endocrinology; 2001 Jan; 142(1):229-40. PubMed ID: 11145586
[TBL] [Abstract][Full Text] [Related]
6. The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets.
Federici M; Hribal ML; Ranalli M; Marselli L; Porzio O; Lauro D; Borboni P; Lauro R; Marchetti P; Melino G; Sesti G
FASEB J; 2001 Jan; 15(1):22-24. PubMed ID: 11099486
[TBL] [Abstract][Full Text] [Related]
7. Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Cousin SP; Hügl SR; Myers MG; White MF; Reifel-Miller A; Rhodes CJ
Biochem J; 1999 Dec; 344 Pt 3(Pt 3):649-58. PubMed ID: 10585851
[TBL] [Abstract][Full Text] [Related]
8. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Briaud I; Dickson LM; Lingohr MK; McCuaig JF; Lawrence JC; Rhodes CJ
J Biol Chem; 2005 Jan; 280(3):2282-93. PubMed ID: 15537654
[TBL] [Abstract][Full Text] [Related]
9. Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated phosphatidylinositol 3-kinase pathway.
Yang L; An HX; Deng XL; Chen LL; Li ZY
Acta Pharmacol Sin; 2003 May; 24(5):429-34. PubMed ID: 12740178
[TBL] [Abstract][Full Text] [Related]
10. Integrative mitogenic role of protein kinase B/Akt in beta-cells.
Trümper K; Trümper A; Trusheim H; Arnold R; Göke B; Hörsch D
Ann N Y Acad Sci; 2000; 921():242-50. PubMed ID: 11193829
[TBL] [Abstract][Full Text] [Related]
11. Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
Lingohr MK; Briaud I; Dickson LM; McCuaig JF; Alárcon C; Wicksteed BL; Rhodes CJ
J Biol Chem; 2006 Jun; 281(23):15884-92. PubMed ID: 16574657
[TBL] [Abstract][Full Text] [Related]
12. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.
Valverde AM; Fabregat I; Burks DJ; White MF; Benito M
Hepatology; 2004 Dec; 40(6):1285-94. PubMed ID: 15565601
[TBL] [Abstract][Full Text] [Related]
13. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.
Welsh N; Makeeva N; Welsh M
Mol Med; 2002 Nov; 8(11):695-704. PubMed ID: 12520086
[TBL] [Abstract][Full Text] [Related]
14. GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
Annerén C; Welsh M
Mol Med; 2002 Nov; 8(11):705-13. PubMed ID: 12520087
[TBL] [Abstract][Full Text] [Related]
15. Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
Hügl SR; White MF; Rhodes CJ
J Biol Chem; 1998 Jul; 273(28):17771-9. PubMed ID: 9651378
[TBL] [Abstract][Full Text] [Related]
16. Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.
Ibrahim YH; Byron SA; Cui X; Lee AV; Yee D
Mol Cancer Res; 2008 Sep; 6(9):1491-8. PubMed ID: 18819936
[TBL] [Abstract][Full Text] [Related]
17. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Schuppin GT; Pons S; Hügl S; Aiello LP; King GL; White M; Rhodes CJ
Diabetes; 1998 Jul; 47(7):1074-85. PubMed ID: 9648831
[TBL] [Abstract][Full Text] [Related]
18. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Valverde AM; Burks DJ; Fabregat I; Fisher TL; Carretero J; White MF; Benito M
Diabetes; 2003 Sep; 52(9):2239-48. PubMed ID: 12941762
[TBL] [Abstract][Full Text] [Related]
19. Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Dickson LM; Rhodes CJ
Am J Physiol Endocrinol Metab; 2004 Aug; 287(2):E192-8. PubMed ID: 15271644
[TBL] [Abstract][Full Text] [Related]
20. IGF-1 protects against dexamethasone-induced cell death in insulin secreting INS-1 cells independent of AKT/PKB phosphorylation.
Avram D; Ranta F; Hennige AM; Berchtold S; Hopp S; Häring HU; Lang F; Ullrich S
Cell Physiol Biochem; 2008; 21(5-6):455-62. PubMed ID: 18453753
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
