387 related articles for article (PubMed ID: 14612418)
1. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway.
Kwak MK; Wakabayashi N; Greenlaw JL; Yamamoto M; Kensler TW
Mol Cell Biol; 2003 Dec; 23(23):8786-94. PubMed ID: 14612418
[TBL] [Abstract][Full Text] [Related]
2. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.
Kwak MK; Wakabayashi N; Itoh K; Motohashi H; Yamamoto M; Kensler TW
J Biol Chem; 2003 Mar; 278(10):8135-45. PubMed ID: 12506115
[TBL] [Abstract][Full Text] [Related]
3. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
Kwak MK; Itoh K; Yamamoto M; Kensler TW
Mol Cell Biol; 2002 May; 22(9):2883-92. PubMed ID: 11940647
[TBL] [Abstract][Full Text] [Related]
4. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.
Itoh K; Wakabayashi N; Katoh Y; Ishii T; O'Connor T; Yamamoto M
Genes Cells; 2003 Apr; 8(4):379-91. PubMed ID: 12653965
[TBL] [Abstract][Full Text] [Related]
5. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Kobayashi A; Kang MI; Okawa H; Ohtsuji M; Zenke Y; Chiba T; Igarashi K; Yamamoto M
Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
[TBL] [Abstract][Full Text] [Related]
6. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
McMahon M; Itoh K; Yamamoto M; Hayes JD
J Biol Chem; 2003 Jun; 278(24):21592-600. PubMed ID: 12682069
[TBL] [Abstract][Full Text] [Related]
7. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Wakabayashi N; Dinkova-Kostova AT; Holtzclaw WD; Kang MI; Kobayashi A; Yamamoto M; Kensler TW; Talalay P
Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2040-5. PubMed ID: 14764894
[TBL] [Abstract][Full Text] [Related]
8. Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.
Sekhar KR; Yan XX; Freeman ML
Oncogene; 2002 Oct; 21(44):6829-34. PubMed ID: 12360409
[TBL] [Abstract][Full Text] [Related]
9. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.
Kobayashi A; Ohta T; Yamamoto M
Methods Enzymol; 2004; 378():273-86. PubMed ID: 15038975
[No Abstract] [Full Text] [Related]
10. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
Zhang DD; Hannink M
Mol Cell Biol; 2003 Nov; 23(22):8137-51. PubMed ID: 14585973
[TBL] [Abstract][Full Text] [Related]
11. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury.
Zhu H; Itoh K; Yamamoto M; Zweier JL; Li Y
FEBS Lett; 2005 Jun; 579(14):3029-36. PubMed ID: 15896789
[TBL] [Abstract][Full Text] [Related]
12. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
Itoh K; Tong KI; Yamamoto M
Free Radic Biol Med; 2004 May; 36(10):1208-13. PubMed ID: 15110385
[TBL] [Abstract][Full Text] [Related]
13. Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction.
Ma Q; Kinneer K; Bi Y; Chan JY; Kan YW
Biochem J; 2004 Jan; 377(Pt 1):205-13. PubMed ID: 14510636
[TBL] [Abstract][Full Text] [Related]
14. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
Kwak MK; Itoh K; Yamamoto M; Sutter TR; Kensler TW
Mol Med; 2001 Feb; 7(2):135-45. PubMed ID: 11471548
[TBL] [Abstract][Full Text] [Related]
15. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers.
Kwak MK; Wakabayashi N; Kensler TW
Mutat Res; 2004 Nov; 555(1-2):133-48. PubMed ID: 15476857
[TBL] [Abstract][Full Text] [Related]
16. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis.
Hirota A; Kawachi Y; Itoh K; Nakamura Y; Xu X; Banno T; Takahashi T; Yamamoto M; Otsuka F
J Invest Dermatol; 2005 Apr; 124(4):825-32. PubMed ID: 15816842
[TBL] [Abstract][Full Text] [Related]
17. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
Katoh Y; Iida K; Kang MI; Kobayashi A; Mizukami M; Tong KI; McMahon M; Hayes JD; Itoh K; Yamamoto M
Arch Biochem Biophys; 2005 Jan; 433(2):342-50. PubMed ID: 15581590
[TBL] [Abstract][Full Text] [Related]
18. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Wakabayashi N; Itoh K; Wakabayashi J; Motohashi H; Noda S; Takahashi S; Imakado S; Kotsuji T; Otsuka F; Roop DR; Harada T; Engel JD; Yamamoto M
Nat Genet; 2003 Nov; 35(3):238-45. PubMed ID: 14517554
[TBL] [Abstract][Full Text] [Related]
19. A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
Lin Y; Martin J; Gruendler C; Farley J; Meng X; Li BY; Lechleider R; Huff C; Kim RH; Grasser WA; Paralkar V; Wang T
BMC Cell Biol; 2002 Jun; 3():15. PubMed ID: 12097147
[TBL] [Abstract][Full Text] [Related]
20. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
Kang MI; Kobayashi A; Wakabayashi N; Kim SG; Yamamoto M
Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2046-51. PubMed ID: 14764898
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
