These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

302 related articles for article (PubMed ID: 14612531)

  • 1. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
    Zhou W; Simpson PJ; McFadden JM; Townsend CA; Medghalchi SM; Vadlamudi A; Pinn ML; Ronnett GV; Kuhajda FP
    Cancer Res; 2003 Nov; 63(21):7330-7. PubMed ID: 14612531
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
    Thupari JN; Pinn ML; Kuhajda FP
    Biochem Biophys Res Commun; 2001 Jul; 285(2):217-23. PubMed ID: 11444828
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75.
    Puig T; Vázquez-Martín A; Relat J; Pétriz J; Menéndez JA; Porta R; Casals G; Marrero PF; Haro D; Brunet J; Colomer R
    Breast Cancer Res Treat; 2008 Jun; 109(3):471-9. PubMed ID: 17902053
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
    Pizer ES; Thupari J; Han WF; Pinn ML; Chrest FJ; Frehywot GL; Townsend CA; Kuhajda FP
    Cancer Res; 2000 Jan; 60(2):213-8. PubMed ID: 10667561
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.
    Menendez JA; Colomer R; Lupu R
    Med Hypotheses; 2005; 64(2):337-41. PubMed ID: 15607568
    [TBL] [Abstract][Full Text] [Related]  

  • 6. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
    Menendez JA; Lupu R
    Int J Mol Med; 2005 Jan; 15(1):33-40. PubMed ID: 15583825
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA; Mehmi I; Atlas E; Colomer R; Lupu R
    Int J Oncol; 2004 Mar; 24(3):591-608. PubMed ID: 14767544
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.
    Bentebibel A; Sebastián D; Herrero L; López-Viñas E; Serra D; Asins G; Gómez-Puertas P; Hegardt FG
    Biochemistry; 2006 Apr; 45(14):4339-50. PubMed ID: 16584169
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
    Menendez JA; Ropero S; Mehmi I; Atlas E; Colomer R; Lupu R
    Int J Oncol; 2004 Jun; 24(6):1369-83. PubMed ID: 15138577
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
    Bandyopadhyay S; Zhan R; Wang Y; Pai SK; Hirota S; Hosobe S; Takano Y; Saito K; Furuta E; Iiizumi M; Mohinta S; Watabe M; Chalfant C; Watabe K
    Cancer Res; 2006 Jun; 66(11):5934-40. PubMed ID: 16740734
    [TBL] [Abstract][Full Text] [Related]  

  • 11. C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA.
    Yang N; Kays JS; Skillman TR; Burris L; Seng TW; Hammond C
    J Pharmacol Exp Ther; 2005 Jan; 312(1):127-33. PubMed ID: 15356215
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
    Zhou W; Han WF; Landree LE; Thupari JN; Pinn ML; Bililign T; Kim EK; Vadlamudi A; Medghalchi SM; El Meskini R; Ronnett GV; Townsend CA; Kuhajda FP
    Cancer Res; 2007 Apr; 67(7):2964-71. PubMed ID: 17409402
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.
    Zhou W; Tu Y; Simpson PJ; Kuhajda FP
    Oncogene; 2009 Aug; 28(33):2979-87. PubMed ID: 19543323
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fatty acid metabolism as a target for obesity treatment.
    Ronnett GV; Kim EK; Landree LE; Tu Y
    Physiol Behav; 2005 May; 85(1):25-35. PubMed ID: 15878185
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
    Li JN; Gorospe M; Chrest FJ; Kumaravel TS; Evans MK; Han WF; Pizer ES
    Cancer Res; 2001 Feb; 61(4):1493-9. PubMed ID: 11245456
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice.
    Li LF; Lu YY; Xiong W; Liu JY; Chen Q
    Eur J Pharmacol; 2008 Oct; 595(1-3):90-4. PubMed ID: 18706411
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C75 activates malonyl-CoA sensitive and insensitive components of the CPT system.
    Nicot C; Napal L; Relat J; González S; Llebaria A; Woldegiorgis G; Marrero PF; Haro D
    Biochem Biophys Res Commun; 2004 Dec; 325(3):660-4. PubMed ID: 15541339
    [TBL] [Abstract][Full Text] [Related]  

  • 18. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.
    Thupari JN; Landree LE; Ronnett GV; Kuhajda FP
    Proc Natl Acad Sci U S A; 2002 Jul; 99(14):9498-502. PubMed ID: 12060712
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates.
    Rendina AR; Cheng D
    Biochem J; 2005 Jun; 388(Pt 3):895-903. PubMed ID: 15715522
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
    Pizer ES; Chrest FJ; DiGiuseppe JA; Han WF
    Cancer Res; 1998 Oct; 58(20):4611-5. PubMed ID: 9788612
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.