BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

273 related articles for article (PubMed ID: 14615375)

  • 41. Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
    McEwan DG; Brunton VG; Baillie GS; Leslie NR; Houslay MD; Frame MC
    Cancer Res; 2007 Jun; 67(11):5248-57. PubMed ID: 17545604
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
    de Rooij J; Zwartkruis FJ; Verheijen MH; Cool RH; Nijman SM; Wittinghofer A; Bos JL
    Nature; 1998 Dec; 396(6710):474-7. PubMed ID: 9853756
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.
    Aumo L; Rusten M; Mellgren G; Bakke M; Lewis AE
    Endocrinology; 2010 May; 151(5):2151-61. PubMed ID: 20233795
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.
    Miklos W; Heffeter P; Pirker C; Hager S; Kowol CR; van Schoonhoven S; Stojanovic M; Keppler BK; Berger W
    Oncotarget; 2016 Dec; 7(51):84556-84574. PubMed ID: 27602951
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Phosphodiesterase type 4 inhibitor suppresses expression of anti-apoptotic members of the Bcl-2 family in B-CLL cells and induces caspase-dependent apoptosis.
    Siegmund B; Welsch J; Loher F; Meinhardt G; Emmerich B; Endres S; Eigler A
    Leukemia; 2001 Oct; 15(10):1564-71. PubMed ID: 11587214
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
    Chepurny OG; Leech CA; Kelley GG; Dzhura I; Dzhura E; Li X; Rindler MJ; Schwede F; Genieser HG; Holz GG
    J Biol Chem; 2009 Apr; 284(16):10728-36. PubMed ID: 19244230
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling.
    Namkoong S; Kim CK; Cho YL; Kim JH; Lee H; Ha KS; Choe J; Kim PH; Won MH; Kwon YG; Shim EB; Kim YM
    Cell Signal; 2009 Jun; 21(6):906-15. PubMed ID: 19385062
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.
    Meyers JA; Su DW; Lerner A
    J Immunol; 2009 May; 182(9):5400-11. PubMed ID: 19380787
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.
    Fukuhara S; Sakurai A; Sano H; Yamagishi A; Somekawa S; Takakura N; Saito Y; Kangawa K; Mochizuki N
    Mol Cell Biol; 2005 Jan; 25(1):136-46. PubMed ID: 15601837
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus.
    Kusama K; Yoshie M; Tamura K; Daikoku T; Takarada T; Tachikawa E
    Reproduction; 2014 Jun; 147(6):897-906. PubMed ID: 24586073
    [TBL] [Abstract][Full Text] [Related]  

  • 51. CAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac?
    Berruti G
    Cell Mol Biol (Noisy-le-grand); 2003 May; 49(3):381-8. PubMed ID: 12887090
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells.
    Bartsch O; Bartlick B; Ivell R
    J Clin Endocrinol Metab; 2004 Jan; 89(1):324-34. PubMed ID: 14715868
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase.
    Sun W; Jiao W; Huang Y; Li R; Zhang Z; Wang J; Lei T
    Biochem Biophys Res Commun; 2017 Apr; 485(2):355-359. PubMed ID: 28216156
    [TBL] [Abstract][Full Text] [Related]  

  • 54. PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.
    Lee R; Wolda S; Moon E; Esselstyn J; Hertel C; Lerner A
    Cell Signal; 2002 Mar; 14(3):277-84. PubMed ID: 11812656
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Cyclic adenosine 3'-5'-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac).
    Vitali E; Peverelli E; Giardino E; Locatelli M; Lasio GB; Beck-Peccoz P; Spada A; Lania AG; Mantovani G
    Mol Cell Endocrinol; 2014 Mar; 383(1-2):193-202. PubMed ID: 24373949
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.
    Jacob C; Szilagyi C; Allen JM; Bertrand C; Lagente V
    Br J Pharmacol; 2004 Sep; 143(2):257-68. PubMed ID: 15313882
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.
    Mei FC; Qiao J; Tsygankova OM; Meinkoth JL; Quilliam LA; Cheng X
    J Biol Chem; 2002 Mar; 277(13):11497-504. PubMed ID: 11801596
    [TBL] [Abstract][Full Text] [Related]  

  • 58. cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.
    Qin Y; Stokman G; Yan K; Ramaiahgari S; Verbeek F; de Graauw M; van de Water B; Price LS
    Br J Pharmacol; 2012 Feb; 165(4b):1137-50. PubMed ID: 21745194
    [TBL] [Abstract][Full Text] [Related]  

  • 59. The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
    Misra UK; Kaczowka S; Pizzo SV
    Cell Signal; 2008 Aug; 20(8):1459-70. PubMed ID: 18495429
    [TBL] [Abstract][Full Text] [Related]  

  • 60. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea.
    Sheikh IA; Koley H; Chakrabarti MK; Hoque KM
    J Biol Chem; 2013 Jul; 288(28):20404-15. PubMed ID: 23720748
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.