These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

388 related articles for article (PubMed ID: 14615966)

  • 1. Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.
    Grillo MP; Hua F; Knutson CG; Ware JA; Li C
    Chem Res Toxicol; 2003 Nov; 16(11):1410-7. PubMed ID: 14615966
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.
    Grillo MP; Hua F
    Chem Res Toxicol; 2008 Sep; 21(9):1749-59. PubMed ID: 18680316
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of zomepirac-S-acyl-glutathione in vitro in incubations with rat hepatocytes and in vivo in rat bile.
    Grillo MP; Hua F
    Drug Metab Dispos; 2003 Nov; 31(11):1429-36. PubMed ID: 14570776
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
    Grillo MP; Hua F; March KL; Benet LZ; Knutson CG; Ware JA
    Chem Res Toxicol; 2008 Oct; 21(10):1933-8. PubMed ID: 18693772
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.
    Grillo MP; Tadano Lohr M; Wait JC
    Drug Metab Dispos; 2012 Aug; 40(8):1515-26. PubMed ID: 22577085
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP; Ma J; Teffera Y; Waldon DJ
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile.
    Grillo MP; Knutson CG; Sanders PE; Waldon DJ; Hua F; Ware JA
    Drug Metab Dispos; 2003 Nov; 31(11):1327-36. PubMed ID: 14570764
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.
    Grillo MP; Wait JC; Tadano Lohr M; Khera S; Benet LZ
    Drug Metab Dispos; 2010 Jan; 38(1):133-42. PubMed ID: 19786506
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid.
    Horng H; Benet LZ
    Chem Res Toxicol; 2013 Mar; 26(3):465-76. PubMed ID: 23402341
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.
    Olsen J; Li C; Skonberg C; Bjørnsdottir I; Sidenius U; Benet LZ; Hansen SH
    Drug Metab Dispos; 2007 May; 35(5):758-64. PubMed ID: 17303625
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ; Chen Y; Deninno MP; O'Connell TN; Hop CE
    Drug Metab Dispos; 2005 Apr; 33(4):484-8. PubMed ID: 15640374
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats.
    Olsen J; Li C; Bjørnsdottir I; Sidenius U; Hansen SH; Benet LZ
    Chem Res Toxicol; 2005 Nov; 18(11):1729-36. PubMed ID: 16300382
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vivo perturbation of rat hepatocyte canalicular membrane function by diclofenac.
    Sallustio BC; Holbrook FL
    Drug Metab Dispos; 2001 Dec; 29(12):1535-8. PubMed ID: 11717171
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective protein adducts to membrane proteins in cultured rat hepatocytes exposed to diclofenac: radiochemical and immunochemical analysis.
    Kretz-Rommel A; Boelsterli UA
    Mol Pharmacol; 1994 Feb; 45(2):237-44. PubMed ID: 8114673
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparative metabolism of the nonsteroidal antiinflammatory drug, aceclofenac, in the rat, monkey, and human.
    Bort R; Ponsoda X; Carrasco E; Gómez-Lechón MJ; Castell JV
    Drug Metab Dispos; 1996 Sep; 24(9):969-75. PubMed ID: 8886606
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes.
    Grillo MP; Lohr MT
    Drug Metab Dispos; 2009 May; 37(5):1073-82. PubMed ID: 19196839
    [TBL] [Abstract][Full Text] [Related]  

  • 19. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites.
    Li C; Benet LZ; Grillo MP
    Chem Res Toxicol; 2002 Oct; 15(10):1309-17. PubMed ID: 12387630
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.