These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 14624546)

  • 1. The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
    Spiteller P; Bai L; Shang G; Carroll BJ; Yu TW; Floss HG
    J Am Chem Soc; 2003 Nov; 125(47):14236-7. PubMed ID: 14624546
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.
    Kubota T; Brünjes M; Frenzel T; Xu J; Kirschning A; Floss HG
    Chembiochem; 2006 Aug; 7(8):1221-5. PubMed ID: 16927319
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.
    Li Y; Zhao P; Kang Q; Ma J; Bai L; Deng Z
    Chem Biol; 2011 Dec; 18(12):1571-80. PubMed ID: 22195559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate.
    Moss SJ; Bai L; Toelzer S; Carroll BJ; Mahmud T; Yu TW; Floss HG
    J Am Chem Soc; 2002 Jun; 124(23):6544-5. PubMed ID: 12047169
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
    Yu TW; Bai L; Clade D; Hoffmann D; Toelzer S; Trinh KQ; Xu J; Moss SJ; Leistner E; Floss HG
    Proc Natl Acad Sci U S A; 2002 Jun; 99(12):7968-73. PubMed ID: 12060743
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility.
    Knobloch T; Harmrolfs K; Taft F; Thomaszewski B; Sasse F; Kirschning A
    Chembiochem; 2011 Mar; 12(4):540-7. PubMed ID: 22238146
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production.
    Pan W; Kang Q; Wang L; Bai L; Deng Z
    Sci China Life Sci; 2013 Jul; 56(7):601-8. PubMed ID: 23832249
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and Engineering of Post-PKS Modification Bottlenecks for Ansamitocin P-3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280.
    Ning X; Wang X; Wu Y; Kang Q; Bai L
    Biotechnol J; 2017 Nov; 12(11):. PubMed ID: 28881098
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
    Carroll BJ; Moss SJ; Bai L; Kato Y; Toelzer S; Yu TW; Floss HG
    J Am Chem Soc; 2002 Apr; 124(16):4176-7. PubMed ID: 11960423
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemoenzymatic approaches toward dechloroansamitocin P-3.
    Meyer A; Brünjes M; Taft F; Frenzel T; Sasse F; Kirschning A
    Org Lett; 2007 Apr; 9(8):1489-92. PubMed ID: 17378571
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.
    Zhao P; Bai L; Ma J; Zeng Y; Li L; Zhang Y; Lu C; Dai H; Wu Z; Li Y; Wu X; Chen G; Hao X; Shen Y; Deng Z; Floss HG
    Chem Biol; 2008 Aug; 15(8):863-74. PubMed ID: 18721757
    [TBL] [Abstract][Full Text] [Related]  

  • 12. N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.
    Wu Y; Kang Q; Shang G; Spiteller P; Carroll B; Yu TW; Su W; Bai L; Floss HG
    Chembiochem; 2011 Jul; 12(11):1759-66. PubMed ID: 21681880
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
    Harmrolfs K; Brünjes M; Dräger G; Floss HG; Sasse F; Taft F; Kirschning A
    Chembiochem; 2010 Dec; 11(18):2517-20. PubMed ID: 21077088
    [No Abstract]   [Full Text] [Related]  

  • 14. Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum.
    Lin J; Bai L; Deng Z; Zhong JJ
    Bioresour Technol; 2011 Jan; 102(2):1863-8. PubMed ID: 20980145
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Complete Genome Sequence of Actinosynnema pretiosum X47, An Industrial Strain that Produces the Antibiotic Ansamitocin AP-3.
    Zhong C; Zong G; Qian S; Liu M; Fu J; Zhang P; Li J; Cao G
    Curr Microbiol; 2019 Aug; 76(8):954-958. PubMed ID: 29858620
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum.
    Taft F; Brünjes M; Knobloch T; Floss HG; Kirschning A
    J Am Chem Soc; 2009 Mar; 131(11):3812-3. PubMed ID: 19292483
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Combinatorial Biosynthesis of 3-
    Liu Q; Wang Y; Xia X; Li Z; Li Y; Shen Y; Wang H
    ACS Synth Biol; 2024 Mar; 13(3):721-727. PubMed ID: 38377312
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum.
    Li S; Lu C; Chang X; Shen Y
    Appl Microbiol Biotechnol; 2016 Mar; 100(6):2641-9. PubMed ID: 26572523
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium.
    Liu T; Yang L; Chen J; Hu F; Wei LJ; Hua Q
    Appl Microbiol Biotechnol; 2020 Apr; 104(8):3555-3568. PubMed ID: 32114676
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A new antitumour ansamitocin from Actinosynnema pretiosum.
    Wei GZ; Bai LQ; Yang T; Ma J; Zeng Y; Shen YM; Zhao PJ
    Nat Prod Res; 2010 Jul; 24(12):1146-50. PubMed ID: 20582809
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.