213 related articles for article (PubMed ID: 14625345)
1. The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.
Nelson SD; Trager WF
Drug Metab Dispos; 2003 Dec; 31(12):1481-98. PubMed ID: 14625345
[TBL] [Abstract][Full Text] [Related]
2. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.
Kim KH; Isin EM; Yun CH; Kim DH; Guengerich FP
FEBS J; 2006 May; 273(10):2223-31. PubMed ID: 16649998
[TBL] [Abstract][Full Text] [Related]
3. Evaluation of cytochrome P450 mechanism and kinetics using kinetic deuterium isotope effects.
Higgins L; Bennett GA; Shimoji M; Jones JP
Biochemistry; 1998 May; 37(19):7039-46. PubMed ID: 9578592
[TBL] [Abstract][Full Text] [Related]
4. Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans.
Ebner T; Meese CO; Eichelbaum M
Mol Pharmacol; 1995 Dec; 48(6):1078-86. PubMed ID: 8848008
[TBL] [Abstract][Full Text] [Related]
5. Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl by cytochrome P450: relationship between distance of methyl groups and masking of the intrinsic isotope effect.
Iyer KR; Jones JP; Darbyshire JF; Trager WF
Biochemistry; 1997 Jun; 36(23):7136-43. PubMed ID: 9188713
[TBL] [Abstract][Full Text] [Related]
6. Aromatic hydrocarbon binding to cytochrome P450 and other enzyme binding sites: are hydrophobic compounds drawn into the active site or pushed from the aqueous phase?
Backes WL; Cawley G; Eyer CS; Means M; Causey KM; Canady WJ
Arch Biochem Biophys; 1993 Jul; 304(1):27-37. PubMed ID: 8323291
[TBL] [Abstract][Full Text] [Related]
7. Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2.
Guengerich FP; Krauser JA; Johnson WW
Biochemistry; 2004 Aug; 43(33):10775-88. PubMed ID: 15311939
[TBL] [Abstract][Full Text] [Related]
8. Probing the mechanism of the carcinogenic activation of N-nitrosodiethanolamine with deuterium isotope effects: in vivo induction of DNA single-strand breaks and related in vitro assays.
Loeppky RN; Fuchs A; Janzowski C; Humberd C; Goelzer P; Schneider H; Eisenbrand G
Chem Res Toxicol; 1998 Dec; 11(12):1556-66. PubMed ID: 9860501
[TBL] [Abstract][Full Text] [Related]
9. Multiple activated oxygen species in P450 catalysis: contributions To specificity in drug metabolism.
Coon MJ; Vaz AD; McGinnity DF; Peng HM
Drug Metab Dispos; 1998 Dec; 26(12):1190-3. PubMed ID: 9860926
[TBL] [Abstract][Full Text] [Related]
10. Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations.
Newcomb M; Aebisher D; Shen R; Chandrasena RE; Hollenberg PF; Coon MJ
J Am Chem Soc; 2003 May; 125(20):6064-5. PubMed ID: 12785830
[TBL] [Abstract][Full Text] [Related]
11. Kinetic isotope effects and 'metabolic switching' in cytochrome P450-catalyzed reactions.
Miwa GT; Lu AY
Bioessays; 1987 Nov; 7(5):215-9. PubMed ID: 3325050
[No Abstract] [Full Text] [Related]
12. Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.
Lewis DF; Ito Y
Xenobiotica; 2009 Aug; 39(8):625-35. PubMed ID: 19514836
[TBL] [Abstract][Full Text] [Related]
13. Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.
Kim DH; Kim KH; Kim DH; Liu KH; Jung HC; Pan JG; Yun CH
Drug Metab Dispos; 2008 Nov; 36(11):2166-70. PubMed ID: 18669587
[TBL] [Abstract][Full Text] [Related]
14. Isotope effect studies on the cytochrome P450 enzymes.
Korzekwa KR; Gillette JR; Trager WF
Drug Metab Rev; 1995; 27(1-2):45-59. PubMed ID: 7641584
[TBL] [Abstract][Full Text] [Related]
15. Kinetic and chemical mechanisms of the fabG-encoded Streptococcus pneumoniae beta-ketoacyl-ACP reductase.
Patel MP; Liu WS; West J; Tew D; Meek TD; Thrall SH
Biochemistry; 2005 Dec; 44(50):16753-65. PubMed ID: 16342966
[TBL] [Abstract][Full Text] [Related]
16. [The use of alternative sources of electrons in mono-oxygenase reactions catalyzed by cytochrome P450. Physico-chemical methods as factors acting on enzymatic activity of proteins].
Shumiantseva VV; Moskvitina TL; Bulko TV; Archakov AI
Vopr Med Khim; 1998; 44(5):423-36. PubMed ID: 9916258
[TBL] [Abstract][Full Text] [Related]
17. The use of isotope effects to determine enzyme mechanisms.
Cleland WW
Arch Biochem Biophys; 2005 Jan; 433(1):2-12. PubMed ID: 15581561
[TBL] [Abstract][Full Text] [Related]
18. An acyl group makes a difference in the reactivity patterns of cytochrome P450 catalyzed N-demethylation of substituted N,N-dimethylbenzamides-high spin selective reactions.
Wang Y; Li D; Han K; Shaik S
J Phys Chem B; 2010 Mar; 114(8):2964-70. PubMed ID: 20146528
[TBL] [Abstract][Full Text] [Related]
19. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
Avent KM; DeVoss JJ; Gillam EM
Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
[TBL] [Abstract][Full Text] [Related]
20. How does product isotope effect prove the operation of a two-state "rebound" mechanism in C-H hydroxylation by cytochrome P450?
Kumar D; de Visser SP; Shaik S
J Am Chem Soc; 2003 Oct; 125(43):13024-5. PubMed ID: 14570465
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
