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2. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. Megonigal MD; Cheung NK; Rappaport EF; Nowell PC; Wilson RB; Jones DH; Addya K; Leonard DG; Kushner BH; Williams TM; Lange BJ; Felix CA Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2814-9. PubMed ID: 10706619 [TBL] [Abstract][Full Text] [Related]
3. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Broeker PL; Super HG; Thirman MJ; Pomykala H; Yonebayashi Y; Tanabe S; Zeleznik-Le N; Rowley JD Blood; 1996 Mar; 87(5):1912-22. PubMed ID: 8634439 [TBL] [Abstract][Full Text] [Related]
4. Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Langer T; Metzler M; Reinhardt D; Viehmann S; Borkhardt A; Reichel M; Stanulla M; Schrappe M; Creutzig U; Ritter J; Leis T; Jacobs U; Harbott J; Beck JD; Rascher W; Repp R Genes Chromosomes Cancer; 2003 Apr; 36(4):393-401. PubMed ID: 12619163 [TBL] [Abstract][Full Text] [Related]
5. Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Aplan PD; Chervinsky DS; Stanulla M; Burhans WC Blood; 1996 Apr; 87(7):2649-58. PubMed ID: 8639880 [TBL] [Abstract][Full Text] [Related]
6. Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Whitmarsh RJ; Saginario C; Zhuo Y; Hilgenfeld E; Rappaport EF; Megonigal MD; Carroll M; Liu M; Osheroff N; Cheung NK; Slater DJ; Ried T; Knutsen T; Blair IA; Felix CA Oncogene; 2003 Nov; 22(52):8448-59. PubMed ID: 14627986 [TBL] [Abstract][Full Text] [Related]
7. Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia. Super HG; Strissel PL; Sobulo OM; Burian D; Reshmi SC; Roe B; Zeleznik-Le NJ; Diaz MO; Rowley JD Genes Chromosomes Cancer; 1997 Oct; 20(2):185-95. PubMed ID: 9331569 [TBL] [Abstract][Full Text] [Related]
8. t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines. Shibuya N; Taki T; Mugishima H; Chin M; Tsuchida M; Sako M; Kawa K; Ishii E; Miura I; Yanagisawa M; Hayashi Y Genes Chromosomes Cancer; 2001 Sep; 32(1):1-10. PubMed ID: 11477655 [TBL] [Abstract][Full Text] [Related]
9. A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. Wechsler DS; Engstrom LD; Alexander BM; Motto DG; Roulston D Genes Chromosomes Cancer; 2003 Jan; 36(1):26-36. PubMed ID: 12461747 [TBL] [Abstract][Full Text] [Related]
10. Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Libura J; Slater DJ; Felix CA; Richardson C Blood; 2005 Mar; 105(5):2124-31. PubMed ID: 15528316 [TBL] [Abstract][Full Text] [Related]
11. In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells. Ishii E; Eguchi M; Eguchi-Ishimae M; Yoshida N; Oda M; Zaitsu M; Fujita I; Miyazaki S; Hamasaki Y; Mizutani S Int J Hematol; 2002 Jul; 76(1):74-9. PubMed ID: 12138900 [TBL] [Abstract][Full Text] [Related]
12. Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks. Bariar B; Vestal CG; Deem B; Goodenow D; Ughetta M; Engledove RW; Sahyouni M; Richardson C Environ Mol Mutagen; 2019 Mar; 60(2):154-167. PubMed ID: 30387535 [TBL] [Abstract][Full Text] [Related]
13. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Stanulla M; Wang J; Chervinsky DS; Thandla S; Aplan PD Mol Cell Biol; 1997 Jul; 17(7):4070-9. PubMed ID: 9199342 [TBL] [Abstract][Full Text] [Related]
14. DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Strissel PL; Strick R; Tomek RJ; Roe BA; Rowley JD; Zeleznik-Le NJ Hum Mol Genet; 2000 Jul; 9(11):1671-9. PubMed ID: 10861294 [TBL] [Abstract][Full Text] [Related]
15. Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion transcripts involving unknown partner genes. Megonigal MD; Rappaport EF; Wilson RB; Jones DH; Whitlock JA; Ortega JA; Slater DJ; Nowell PC; Felix CA Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9597-602. PubMed ID: 10920186 [TBL] [Abstract][Full Text] [Related]
16. MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Moneypenny CG; Shao J; Song Y; Gallagher EP Carcinogenesis; 2006 Apr; 27(4):874-81. PubMed ID: 16377807 [TBL] [Abstract][Full Text] [Related]
17. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Alexander FE; Patheal SL; Biondi A; Brandalise S; Cabrera ME; Chan LC; Chen Z; Cimino G; Cordoba JC; Gu LJ; Hussein H; Ishii E; Kamel AM; Labra S; Magalhães IQ; Mizutani S; Petridou E; de Oliveira MP; Yuen P; Wiemels JL; Greaves MF Cancer Res; 2001 Mar; 61(6):2542-6. PubMed ID: 11289128 [TBL] [Abstract][Full Text] [Related]
18. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Lovett BD; Strumberg D; Blair IA; Pang S; Burden DA; Megonigal MD; Rappaport EF; Rebbeck TR; Osheroff N; Pommier YG; Felix CA Biochemistry; 2001 Feb; 40(5):1159-70. PubMed ID: 11170441 [TBL] [Abstract][Full Text] [Related]
19. The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Luo RT; Lavau C; Du C; Simone F; Polak PE; Kawamata S; Thirman MJ Mol Cell Biol; 2001 Aug; 21(16):5678-87. PubMed ID: 11463848 [TBL] [Abstract][Full Text] [Related]
20. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators. Wiemels JL; Pagnamenta A; Taylor GM; Eden OB; Alexander FE; Greaves MF Cancer Res; 1999 Aug; 59(16):4095-9. PubMed ID: 10463613 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]